Stability of cognitive impairment in chronic schizophrenia over brief and intermediate re‐test intervals

Human Psychopharmacology - Tập 24 Số 2 - Trang 113-121 - 2009
Robert H. Pietrzak1, Peter J. Snyder2,3, Colleen E. Jackson4, James Olver5, Trevor R. Norman5, Danijela Piškulić5, Paul Maruff6,7
1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA
2Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
3Department of Clinical Neurosciences, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
4Department of Psychology, University of Connecticut, Storrs, Connecticut, USA
5Department of Psychiatry, University of Melbourne School of Medicine, Melbourne, Victoria, Australia
6Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia
7Cogstate Ltd., Melbourne, Victoria, Australia

Tóm tắt

AbstractObjectiveThis study examined between‐ and within‐subject stability of cognitive performance in individuals with chronic schizophrenia.MethodsThirty individuals with schizophrenia and 20 healthy controls matched by age, sex, education, and estimated IQ underwent repeated cognitive assessments at baseline and 30 days using computerized tests of psychomotor function, visual attention/information processing, non‐verbal learning, and executive function.ResultsCompared to healthy controls, individuals with schizophrenia scored lower on all cognitive measures and demonstrated greater variability in cognitive performance. Within‐subject variability in cognitive performance in both the schizophrenia and healthy control groups remained stable at brief (i.e., hours) and intermediate (i.e., one month) assessments.ConclusionsThese results demonstrate the stability of between‐ and within‐subject variability in cognitive performance in schizophrenia, and suggest that variability in cognitive performance may reflect an inherent characteristic of the disorder, rather than differences in test–retest reliability/error of cognitive measures. Copyright © 2008 John Wiley & Sons, Ltd.

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Human Psychopharmacology

Tập 24 Số 2

113-121

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