Stability and biotransformation of various dietary anthocyanins in vitro

Satué–Gracia MT, Heinonen M, Frankel EN (1997) Anthocyanins as antioxidants on human low–density lipoprotein and lecithin–liposome systems. J Agric Food Chem 45:3362–3367

Wang H, Coa G, Prior RL (1997) Oxygen Radical Absorbing Capacity of anthocyanins. J Agric Food Chem 45:304–309

Pool–Zobel BL, Bub A, Schroder N, Rechkemmer G (1999) Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells. Eur J Nutr 38:227–234

Kähkönen M, Heinonen M (2003) Antioxidant activity of anthocyanins and their aglycones. J Agric Food Chem 51:628–633

Wang H, Nair MG, Strasburg GM, Chang YC, Booren AM, Gray JI, DeWitt DL (1999) Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod 62:294–296

Hou DX (2003) Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 3:149–159

Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori M (2003) Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem 51:68–75

Netzel M, Strass G, Janssen M, Bitsch I, Bitsch R (2001) Bioactive anthocyanins detected in human urine after ingestion of blackcurrant juice. J Environ Pathol Toxicol Oncol 20:89–95

Bub A, Watzl B, Heeb D, Rechkemmer G, Briviba K (2001) Malvidin–3–glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur J Nutr 40:113–120

Wu X, Cao G, Prior RL (2002) Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. J Nutr 132:1865–1871

Felgines C, Talavera S, Gonthier MP, Texier O, Scalbert A, Lamaison JL, Remesy C (2003) Strawberry anthocyanins are recovered in urine as glucuro– and sulfoconjugates in humans. J Nutr 133:1296–1301

Wang LQ, Meselhy MR, Li Y, Qin GW, Hattori M (2000) Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone. Chem Pharm Bull (Tokyo) 48:1606–1610

Lake BG (1987) Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism. In: Snell K, Mullock B (eds) Biochemical Toxicology: A practical approach. IRL Press, Oxford, UK, pp 183–215

Fleschhut J, Rechkemmer G, Winterhalter P, Kulling S (2003) Bioavailability and metabolism of anthocyanins, Proceedings of the 1st International Conference on Polyphenols and Health, November 18–21:2003, Vichy, France, p 281

Giusti MM, Wrolstad RE (1996) Characterization of red radish anthocyanins. J Food Science 61:322–326

Hsu T, Daniel SL, Lux MF, Drake HL (1990) Biotransformation of carboxylated aromatic compounds by the acetogen Clostridium thermoaceticum:Generation of growth–supportive CO2 equivalents under CO2–limited conditions. J Bact 172:212–217

Ueda J, Saito N, Shimazu Y, Ozawa T (1996) A comparison of scavenging abilities of antioxidants against hydroxyl radicals. Arch Biochem Biophys 333:377–384

Tseng TH, Wang CJ, Kao ES, Chu HY (1996) Hibiscus protocatechuic acid protects against oxidative damage induced by tert–butylhydroperoxide in rat primary hepatocytes. Chem Biol Interact 101:137–148

Tanaka T, Kojima T, Kawamori T, Yoshimi N, Mori H (1993) Chemoprevention of diethylnitrosamine–induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats. Cancer Res 53:2775–2779

Tanaka T, Kojima T, Suzui M, Mori H (1993) Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid:suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Res 53:3908–3913

Tanaka T, Kawamori T, Ohnishi M, Okamoto K, Mori H, Hara A (1994) Chemoprevention of 4–nitroquinoline 1–oxide–induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases. Cancer Res 54:2359–2365

Tanaka T, Kojima T, Kawamori T, Mori H (1995) Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid. Cancer 75:1433–1439

Ohnishi M, Yoshimi N, Kawamori T, Ino N, Hirose Y, Tanaka T, Yamahara J, Miyata H, Mori H (1997) Inhibitory effects of dietary protocatechuic acid and costunolide on 7, 12–dimethylbenz[a]anthracene– induced hamster cheek pouch carcinogenesis. Jpn J Cancer Res 88:111–119

Tseng TH, Hsu JD, Lo MH, Chu CY, Chou FP, Huang CL, Wang CJ (1998) Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett 126:199–207