Spring support electromagnetic induction-based detection sensor for the coagulation process
Tóm tắt
Coagulation detection is a vital check item for patients undergoing surgery, and those with immunological disease and cardiovascular disease in clinic. Exploring the dynamic detection of the whole coagulation process has long been the research hotspot of experts and scholars. This study had proposed a novel electromagnetic type coagulation detector, which used the round and leaf spring as the middle spring support, with dynamic testing sensor technology of coagulation in vitro as the research objective. The vibration system constituted by support spring and electromagnetic induction device was theoretically analyzed through dynamic modeling of sensor. We conducted modal analysis and harmonic response analysis on the spring support group using finite element method, optimized the analysis results, manufactured the sensor experimental prototype, and constructed the coagulation testing device. We also tested the velocity spectral characteristics and displacement spectral characteristics of the sensor prototype, established the standard curve of POCT (point-of-care testing, POCT) in the rapid detection of coagulation through matching the coagulation testing device with coagulation reagent, and compared its methodology with the imported POCT coagulometer system. Our results suggested that, the vibration velocity of the sensor designed in this study was 1.5 μm/s, and the amplitude was 1.75 × 10−3 μm. The correlation with the imported POCT coagulometer system in terms of test results was as high as 0.996, and the repeatability was 0.002. This study can provide theory and experimental foundation for the electromagnetic vibration induction technology in coagulation detection.
Tài liệu tham khảo
Anand M, Rajagopal K, Rajagopal KR (2008) A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. J Theor Biol 253(4):725–738
Andersson M, Sellborn A, Fant C, Gretzer C, Elwing H (2002) Acoustics of blood plasma on solid surfaces. J Biomater Sci Polym Ed 13(8):907–917
Asadi E, Askari H, Khamesee MB, Khajepour A (2017) High frequency nano electromagnetic self-powered sensor: concept, modelling and analysis. Measurement 107:31–40
Bates SM, Weitz JI (2005) Coagulation assays. Circulation 112(4):E53–E60
Chen D, Song S, Ma J, Zhang Z, Wang P, Liu W, Guo Q (2017a) Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring. Biosens Bioelectron 91:465
Chen Q, Zhang G, Wang Z, Zhang J (2017b) Design of accurate adjustment mechanism for the attitude sensor. Chin J Sci Instrum 38(08):1926–1932
Collet JP, Shuman H, Ledger RE, Lee ST, Weisel JW (2005) The elasticity of an individual fibrin fiber in a clot. Proc Natl Acad Sci USA 102(26):9133–9137
Herbstreit F, Winter EM, Peters J, Hartmann M (2010) Monitoring of hemostasis in liver transplantation: comparison of laboratory based and point of care tests. Anesthesia 65(1):44–49
Kitchen DP, Jennings I, Kitchen S, Woods TAL, Walker ID (2015) Bridging the gap between point-of-care testing and laboratory testing in hemostasis. Semin Thromb Hemost 41(3):272–278
Lippi G, Favaloro EJ, Franchini M, Guidi GC (2009) Milestones and perspectives in coagulation and hemostasis. Semin Thromb Hemost 35(1):9–22
Liu SP, Zhou Q, Chen GM (2011) Investigation on a novel sensing technology for the detection of blood coagulation based on liquid resonance characteristics. Adv Eng Forum 1598(2):253–256
Maliaritsi E, Zoumpoulakis L, Simitzis J, Vassiliou P, Hristoforou E (2005) Coagulation sensors based on magnetostrictive delay lines for biomedical and chemical engineering applications. J Magn Magn Mater 299(1):41–52
Prateek GV, Hurtado M, Nehorai A (2017) Target detection using weather radars and electromagnetic vector sensors. Signal Process 137:387–397
Qari MH (2005) High throughput coagulation analyzers review. Combin Chem High Throughput Screen 8(4):353–360
Quick AJ, Stanleybrown M, Bancroft FW (1980) A study of the coagulation defect in hemophilia and in jaundice. Thromb Haemost 44(1):2–5
Wang Z, Yu Y, Yu Z, Chen Q (2018a) Electromagnetic induction sensor for dynamic testing of coagulation process. Australas Phys Eng Sci Med 41(01):105–115
Wang Z, Yu Y, Yu Z, Chen Q (2018b) Blood coagulation dynamic testing sensor based on electromagnetic vibration. Chin J Sci Instrum 39(1):127–135