Sonic Hedgehog Stimulates Mouse Embryonic Stem Cell Proliferation by Cooperation of Ca2+/Protein Kinase C and Epidermal Growth Factor Receptor As Well as Gli1 Activation

Beachy, 2004, Tissue repair and stem cell renewal in carcinogenesis, Nature, 432, 324, 10.1038/nature03100

Kwon, 2006, Differential regulation of tyrosine hydroxylase expression by sonic hedgehog, Neuroreport, 17, 693, 10.1097/01.wnr.0000209043.66482.0b

Stepan, 2005, Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells, J Biol Chem, 280, 15700, 10.1074/jbc.M413037200

Karpen, 2001, The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane, J Biol Chem, 276, 19503, 10.1074/jbc.M010832200

Ruiz i Altaba, 2004, Hedgehog-Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer, Cancer Lett, 204, 145, 10.1016/S0304-3835(03)00451-8

Ruiz i Altaba, 2002, Hedgehog-Gli signaling and the growth of the brain, Nat Rev Neurosci, 3, 24, 10.1038/nrn704

Clement, 2007, Hedgehog-Gli1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity, Curr Biol, 17, 165, 10.1016/j.cub.2006.11.033

Murone, 1999, Sonic hedgehog signaling by the patched-smoothened receptor complex, Curr Biol, 9, 76, 10.1016/S0960-9822(99)80018-9

Osawa, 2006, Sonic hedgehog stimulates the proliferation of rat gastric mucosal cells through ERK activation by elevating intracellular calcium concentration, Biochem Biophys Res Commun, 344, 680, 10.1016/j.bbrc.2006.03.188

Berridge, 2003, Calcium signalling: Dynamics, homeostasis and remodelling, Nat Rev Mol Cell Biol, 4, 517, 10.1038/nrm1155

Heo, 2006, EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca2+ influx and p44/42 MAPKs, Am J Physiol Cell Physiol, 290, C123, 10.1152/ajpcell.00142.2005

Kasper, 2006, Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes, Mol Cell Biol, 26, 6283, 10.1128/MCB.02317-05

Bigelow, 2005, Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes, J Invest Dermatol, 124, 457, 10.1111/j.0022-202X.2004.23590.x

Kenney, 2000, Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors, Mol Cell Biol, 20, 9055, 10.1128/MCB.20.23.9055-9067.2000

Yoon, 2002, Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation, J Biol Chem, 277, 5548, 10.1074/jbc.M105708200

Weissman, 2001, Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations, Annu Rev Cell Dev Biol, 17, 387, 10.1146/annurev.cellbio.17.1.387

Smith, 2001, Embryo-derived stem cells: Of mice and men, Annu Rev Cell Dev Biol, 17, 435, 10.1146/annurev.cellbio.17.1.435

Heo, 2006, ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways, Stem Cells, 24, 2637, 10.1634/stemcells.2005-0588

Heo, 2006, PKC and MAPKs pathways mediate EGF-induced stimulation of 2-deoxyglucose uptake in mouse embryonic stem cells, Cell Physiol Biochem, 17, 145, 10.1159/000092076

Chen, 2005, Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line, Osteoporos Int, 16, 2039, 10.1007/s00198-005-1995-0

Zhang, 2005, Cell cycle synchronization of embryonic stem cells: effect of serum deprivation on the differentiation of embryonic bodies in vitro, Biochem Biophys Res Commun, 333, 1171, 10.1016/j.bbrc.2005.05.200

Mackman, 1991, Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites, J Exp Med, 174, 1517, 10.1084/jem.174.6.1517

Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3

Takeshita, 2007, Critical role of endothelial Notch1 signaling in postnatal angiogenesis, Circ Res, 100, 70, 10.1161/01.RES.0000254788.47304.6e

Zechner, 2003, β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system, Dev Biol, 258, 406, 10.1016/S0012-1606(03)00123-4

Riobo, 2006, Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling, Cancer Res, 66, 839, 10.1158/0008-5472.CAN-05-2539

Neill, 2003, Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma, Cancer Res, 63, 4692

Luttrell, 1999, Regulation of tyrosine kinase cascades by G-protein-coupled receptors, Curr Opin Cell Biol, 11, 177, 10.1016/S0955-0674(99)80023-4

Hackel, 1999, Epidermal growth factor receptors: critical mediators of multiple receptor pathways, Curr Opin Cell Biol, 11, 184, 10.1016/S0955-0674(99)80024-6

Shah, 2006, Role of metalloproteinase-dependent EGF receptor activation in α-adrenoceptor-stimulated MAP kinase phosphorylation in GT1–7 neurons, J Neurochem, 96, 520, 10.1111/j.1471-4159.2005.03585.x

Filardo, 2000, Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF, Mol Endocrinol, 14, 1649, 10.1210/mend.14.10.0532

Fischer, 2003, EGFR signal transactivation in cancer cells, Biochem Soc Trans, 31, 1203, 10.1042/bst0311203

Biscardi, 1999, c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function, J Biol Chem, 274, 8335, 10.1074/jbc.274.12.8335

Tsai, 1997, The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity, EMBO J, 16, 4597, 10.1093/emboj/16.15.4597

Zwick, 1997, Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling, J Biol Chem, 272, 24767, 10.1074/jbc.272.40.24767

Eguchi, 1998, Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells, J Biol Chem, 273, 8890, 10.1074/jbc.273.15.8890

Soltoff, 1998, Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation, J Biol Chem, 273, 23110, 10.1074/jbc.273.36.23110

Venkatakrishnan, 2000, Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells, J Biol Chem, 275, 6868, 10.1074/jbc.275.10.6868

Kodama, 2002, Role of EGF Receptor and Pyk2 in endothelin-1-induced ERK activation in rat cardiomyocytes, J Mol Cell Cardiol, 34, 139, 10.1006/jmcc.2001.1496

Prenzel, 1999, EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF, Nature, 402, 884, 10.1038/47260

Amin, 1999, Hedgehog activates the EGF receptor pathway during Drosophila head development, Development, 126, 2623, 10.1242/dev.126.12.2623

Mimeault, 2006, Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells, Int J Cancer, 118, 1022, 10.1002/ijc.21440

Palma, 2005, Sonic hedgehog controls stem cell behavior in the postnatal and adult brain, Development, 132, 335, 10.1242/dev.01567

Hu, 2007, Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells, Acta Pharmacol Sin, 28, 1224, 10.1111/j.1745-7254.2007.00620.x

Valdes, 2007, NF-κB activation by depolarization of skeletal muscle cells depends on ryanodine and IP3 receptors-mediated calcium signals, Am J Physiol Cell Physiol, 292, C1960, 10.1152/ajpcell.00320.2006

Liptay, 2003, Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer, Int J Cancer, 105, 735, 10.1002/ijc.11081

Nakashima, 2006, Nuclear factor- κB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer, Cancer Res, 66, 7041, 10.1158/0008-5472.CAN-05-4588

Schmidt-Ullrich, 2006, NF-κB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth, Development, 133, 1045, 10.1242/dev.02278

Duman-Scheel, 2002, Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E, Nature, 417, 299, 10.1038/417299a

Yan, 2001, Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate, J Cell Physiol, 186, 338, 10.1002/1097-4652(2000)9999:9999<000::AID-JCP1032>3.0.CO;2-B

Chen, 1998, Increased cell growth and tumorigenicity in human prostate LNCaP cells by overexpression to cyclin D1, Oncogene, 16, 1913, 10.1038/sj.onc.1201719

Guttridge, 1999, NF-kB controls cell growth and differentiation through the transcriptional regulation of cyclin D1, Mol Cell Biol, 19, 5785, 10.1128/MCB.19.8.5785

Burdon, 2002, Signalling, cell cycle and pluripotency in embryonic stem cells, Trends Cell Biol, 12, 432, 10.1016/S0962-8924(02)02352-8

Chen, 2007, Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis, Cancer Sci, 98, 68, 10.1111/j.1349-7006.2006.00353.x

Cheng, 2000, Hematopoietic stem cell quiescence maintained by p21cip1/waf1, Science, 287, 1804, 10.1126/science.287.5459.1804