Soluble endoglin and transforming growth factor‐β1 in women who subsequently developed preeclampsia

Prenatal Diagnosis - Tập 29 Số 5 - Trang 471-476 - 2009
Ji Hyae Lim1, Shin Young Kim1, So Yeon Park1, Moon Hee Lee1, Jae Hyug Yang2, Moon Young Kim2, Jin Hoon Chung2, Si Won Lee2, Hyun Mee Ryu2,1
1The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea
2The Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, KwanDong University College of Medicine, Seoul, Korea

Tóm tắt

AbstractObjectiveThis study aimed to analyze the differences of soluble endoglin (sEng) and transforming growth factor‐beta1 (TGF‐β1) according to preeclamptic complications and to investigate the correlation between these factors and the clinical symptoms of preeclampsia.MethodWe estimated the levels of sEng and TGF‐β1 in plasma collected in the second trimester at the time of genetic amniocentesis from 60 women who subsequently developed preeclampsia and 124 contemporaneous normotensive women.ResultssEng levels were higher in cases than in controls, whereas TGF‐β1 levels were lower (P < 0.001). sEng levels, but not TGF‐β1 levels, were higher in cases with severe or preterm delivery than in cases with mild preeclampsia or term delivery (P < 0.001) and were increased in cases destined to deliver a small gestational age neonate (P < 0.001). Moreover, sEng levels, but not TGF‐β1 levels, showed a positive correlation with maximum diastolic and systolic blood pressure (r = 0.57, P < 0.001; and r = 0.33, P < 0.001, respectively) and proteinuria (r = 0.42, P < 0.001).ConclusionEarly midtrimester plasma levels of sEng are predictive of subsequence occurrence and severity of preeclampsia, in terms of severity of hypertension and proteinuria, prematurity, and association with small for gestational age neonates. Copyright © 2009 John Wiley & Sons, Ltd.

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Prenatal Diagnosis

Tập 29 Số 5

471-476

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