Soft tissue sarcoma across the age spectrum: A population‐based study from the surveillance epidemiology and end results database

Pediatric Blood and Cancer - Tập 57 Số 6 - Trang 943-949 - 2011
Andrea Ferrari1, Iyad Sultan2, Tseng Tien Huang3, Carlos Rodríguez‐Galindo4, Ahmad Shehadeh5, Cristina Meazza1, Kirsten K. Ness3, Michela Casanova1, Sheri L. Spunt6,7
1Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy
2Department of Pediatric Oncology, King Hussein Cancer Center, Amman, Jordan
3Department of Epidemiology & Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee
4Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, Massachusetts
5Department of Surgery, Orthopedic Oncology Unit, King Hussein Cancer Center, Amman, Jordan
6Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee
7Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee

Tóm tắt

AbstractBackgroundSoft tissue sarcomas (STS) are a heterogeneous group of mesenchymal malignancies that occur throughout the lifespan. The impact of age on disease features and outcome is unclear.MethodsWe analyzed the clinical features and outcome of all STS cases registered between 1973 and 2006 in the SEER database.ResultsThere were 48,012 cases that met the selection criteria. Individuals less than 20 years of age represented 5.6%, with rhabdomyosarcoma being the most common subtype. In adults, the most common types were Kaposi sarcoma, fibrohistiocytic tumors, and leiomyosarcoma. Rhabdomyosarcoma was the only entity with a median age <20 years. Male predominance (male/female of 1.5:1) was noticed for almost all types of STS, except for alveolar soft part sarcoma and leiomyosarcoma. Tumor stage was similar across different age groups. Younger patients (<50 years) had significantly better survival than older patients (88.8 ± 0.2% vs. 40 ± 0.3%, P < 0.001), but for most histologies the survival decline with advancing age was gradual and did not occur abruptly at the onset of adulthood. The decline in survival with advancing age was particularly significant for rhabdomyosarcoma.ConclusionWith few exceptions, the clinical features of STS are similar in children and adults. However, individuals over 50 years of age have an inferior survival. Pediatr Blood Cancer 2011; 57: 943–949. © 2011 Wiley‐Liss, Inc.

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Tài liệu tham khảo

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Pediatric Blood and Cancer

Tập 57 Số 6

943-949

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