Sodium butyrate alleviates fructose-induced non-alcoholic fatty liver disease by remodeling gut microbiota to promote γ-amino butyric acid production

M.H. Le. 2019 Global NAFLD prevalence: a systematic review and meta-analysis. 2022, 20(12): 2809-2817. H. Basciano. Fructose, insulin resistance, and metabolic dyslipidemia. 2005, 2: 5. R.B. Canani. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. 2011, 17: 1519-1528. G. Clarke. Minireview: gut microbiota: the neglected endocrine organ. 2014, 28: 1221-1238. W.H. Zhang. Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. 2011, 52: 292-301. S. Ploger. Microbial butyrate and its role for barrier function in the gastrointestinal tract. 2012, 1258: 52-59. E. Chang. CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes. 2018, 13: e0206152. B. Sun. Sodium butyrate protects against high-fat diet-induced oxidative stress in rat liver by promoting expression of nuclear factor E2-related factor 2. 2019, 122: 400-410. S. Khan. fat accumulation and dyslipidemia in type-2 diabetic rat: a comparative study with metformin. 2016, 254: 124-134. D. Zhou. Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. 2017, 23: 60-75. R.B. Jones. High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome. 2019, 10: 712-719. J. Boursier. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. 2016, 63: 764-775. P. Gkolfakis. Gut microbiota and nonalcoholic fatty liver disease. 2015, 14: 572-581. V. Tremaroli. Functional interactions between the gut microbiota and host metabolism. 2012, 489: 242-249. W. Fang. Supplementation with sodium butyrate modulates the composition of the gut microbiota and ameliorates highfat diet-induced obesity in mice. 2019, 149: 747-754. G. den Besten. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. 2013, 54: 2325-2340. T.J. Borody. and future directions. 2013, 15: 337. W.B. Dunn. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. 2011, 6: 1060-1083. E. Zelena. Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum. 2009, 81: 1357-1364. W. Chen. A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics. 2013, 6: 1769-1780. E.J. Want. Global metabolic profiling of animal and human tissues via UPLC-MS. 2013, 8: 17-32. Y.C. Wang. 1988-2004. 2008, 121: e1604-14. J.S. Sullivan. Oral fructose absorption in obese children with non-alcoholic fatty liver disease. 2015, 10: 188-195. M. Chung. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. 2014, 100: 833-849. C. Sellmann. Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time. 2015, 26: 1183-1192. T. Jensen. Fructose and sugar: a major mediator of non-alcoholic fatty liver disease. 2018, 68: 1063-1075. C.D. Kane. and rat acyl-CoA oxidase promoters by PPARalpha. 2006, 380: 84-94. Y. Zhang. Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase. 2016, 1861: 130-137. J.M. Orellana-Gavalda. Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation. 2011, 53: 821-832. P. Ma. A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice. 2022, 11: 1544-1554. S. Jung. Dietary fructose and fructose-induced pathologies. 2022, 42: 45-66. Song M.. Dietary fructose induced gut microbiota dysbiosis is an early event in the onset of metabolic phenotype. 2019, 33: 723.2. A.N. Payne. artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity. 2012, 13: 799-809. L.K. Stenman. body weight gain and glucose metabolism in humans-towards treatment with probiotics. 2016, 7: 11-22. T.S. Kang. Regulation of dual glycolytic pathways for fructose metabolism in heterofermentative Lactobacillus panis PM1. 2013, 79: 7818-7826. D.P. Neveling. Fructophilic Lactobacillus kunkeei and Lactobacillus brevis isolated from fresh flowers, bees and bee-hives. 2012, 65: 507-515. M. Rossi. Fermentation of fructooligosaccharides and inulin by bifidobacteria: a comparative study of pure and fecal cultures. 2005, 71: 6150-6158. Fuller R.. Probiotics in man and animals. 1989, 66: 365-378. A. Azarang. Protective role of probiotic supplements in hepatic steatosis: a rat model study. 2020, 2020: 5487659. E.E. Canfora. Gut microbial metabolites in obesity, NAFLD and T2DM. 2019, 15: 261-273. C. Jang. The small intestine converts dietary fructose into glucose and organic acids. 2018, 27: 351-361. Y. Hou. A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut. 2021, 12: 271. M.S. Su. Contribution of glutamate decarboxylase in Lactobacillus reuteri to acid resistance and persistence in sourdough fermentation, Microb. 2011, 10(Suppl 1): S8. D. Dahiya. An overview of bioprocesses employing specifically selected microbial catalysts for gamma-aminobutyric acid production. 2021, 9: 2457. Q. Wu. High gamma-aminobutyric acid production from lactic acid bacteria: emphasis on Lactobacillus brevis as a functional dairy starter. 2017, 57: 3661-3672. X. Si. Gamma-aminobutyric acid enriched rice bran diet attenuates insulin resistance and balances energy expenditure via modification of gut microbiota and short-chain fatty acids. 2018, 66: 881-890.