Smooth Muscle Cell–targeted RNA Aptamer Inhibits Neointimal Formation

Molecular Therapy - Tập 24 - Trang 779-787 - 2016
William H Thiel1, Carla L Esposito2, David D Dickey1, Justin P Dassie1, Matthew E Long3, Joshua Adam1, Jennifer Streeter1, Brandon Schickling1, Maysam Takapoo1, Katie S Flenker1, Julia Klesney-Tait1, Vittorio de Franciscis2, Francis J Miller1,4, Paloma H Giangrande1
1Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
2Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy
3Department of Microbiology, University of Washington, Seattle, Washington, USA
4The Veterans Affairs Medical Center, Iowa City, Iowa, USA

Tài liệu tham khảo

Lopez, 2006, Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data, Lancet, 367, 1747, 10.1016/S0140-6736(06)68770-9 Heidenreich, 2011, Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association, Circulation, 123, 933, 10.1161/CIR.0b013e31820a55f5 Sollott, 1995, Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat, J Clin Invest, 95, 1869, 10.1172/JCI117867 Axel, 1997, Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery, Circulation, 96, 636, 10.1161/01.CIR.96.2.636 Fattori, 2003, Drug-eluting stents in vascular intervention, Lancet, 361, 247, 10.1016/S0140-6736(03)12275-1 Curcio, 2011, Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy, Circ J, 75, 1287, 10.1253/circj.CJ-11-0366 Centemero, 2012, Stent thrombosis: an overview, Expert Rev Cardiovasc Ther, 10, 599, 10.1586/erc.12.38 Kedia, 2007, Stent thrombosis with drug-eluting stents: a re-examination of the evidence, Catheter Cardiovasc Interv, 69, 782, 10.1002/ccd.21061 Garg, 2013, New concepts in the design of drug-eluting coronary stents, Nat Rev Cardiol, 10, 248, 10.1038/nrcardio.2013.13 Corti, 2012, Long-term patient benefit with biodegradable polymer biolimus eluting stent, Minerva Cardioangiol, 60, 629 Lupi, 2014, Biodegradable versus durable polymer drug eluting stents in coronary artery disease: insights from a meta-analysis of 5,834 patients, Eur J Prev Cardiol, 21, 411, 10.1177/2047487312467745 Kaul, 2015, Paclitaxel-Eluting versus Everolimus-Eluting Coronary Stents in Diabetes, N Engl J Med, 373, 1709, 10.1056/NEJMoa1510188 Tang, 2014, Smooth muscle-specific drug targets for next-generation drug-eluting stent, Expert Rev Cardiovasc Ther, 12, 21, 10.1586/14779072.2014.866518 Thiel, 2012, Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection, PLoS One, 7, e43836, 10.1371/journal.pone.0043836 Ellington, 1990, In vitro selection of RNA molecules that bind specific ligands, Nature, 346, 818, 10.1038/346818a0 Thiel, 2009, Therapeutic applications of DNA and RNA aptamers, Oligonucleotides, 19, 209, 10.1089/oli.2009.0199 Keefe, 2010, Aptamers as therapeutics, Nat Rev Drug Discov, 9, 537, 10.1038/nrd3141 Sundaram, 2013, Therapeutic RNA aptamers in clinical trials, Eur J Pharm Sci, 48, 259, 10.1016/j.ejps.2012.10.014 Sundaram, 2013, Therapeutic RNA aptamers in clinical trials, Eur J Pharm Sci, 48, 259, 10.1016/j.ejps.2012.10.014 Esposito, 2011, A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death, PLoS One, 6, e24071, 10.1371/journal.pone.0024071 Povsic, 2013, A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial, Eur Heart J, 34, 2481, 10.1093/eurheartj/ehs232 Chan, 2008, A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor, J Thromb Haemost, 6, 789, 10.1111/j.1538-7836.2008.02932.x Jawien, 1992, Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty, J Clin Invest, 89, 507, 10.1172/JCI115613 Kumar, 1997, Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow, Arterioscler Thromb Vasc Biol, 17, 2238, 10.1161/01.ATV.17.10.2238 Oshiro, 2014, Pluronics f-127/l-81 binary hydrogels as drug-delivery systems: influence of physicochemical aspects on release kinetics and cytotoxicity, Langmuir, 30, 13689, 10.1021/la503021c Cheng, 2014, Thrombin induces ICAM-1 expression in human lung epithelial cells via c-Src/PDGFR/PI3K/Akt-dependent NF-κB/p300 activation, Clin Sci (Lond), 127, 171, 10.1042/CS20130676 Lee, 2007, TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells, Am J Physiol Lung Cell Mol Physiol, 292, L799, 10.1152/ajplung.00311.2006 Lok, 2002, Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides, Biochemistry, 41, 3457, 10.1021/bi0115075 Zhang, 2004, Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways, Mol Cancer Ther, 3, 187, 10.1158/1535-7163.187.3.2 Tarner, 2004, Targeted gene therapy: frontiers in the development of ‘smart drugs', Trends Biotechnol, 22, 304, 10.1016/j.tibtech.2004.04.001 Hart, 1999, PDGFbeta receptor blockade inhibits intimal hyperplasia in the baboon, Circulation, 99, 564, 10.1161/01.CIR.99.4.564 Sirois, 1997, Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening, Circulation, 95, 669, 10.1161/01.CIR.95.3.669 Caglayan, 2011, Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo, J Am Coll Cardiol, 57, 2527, 10.1016/j.jacc.2011.02.037 Koyama, 1994, Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells, Circ Res, 75, 682, 10.1161/01.RES.75.4.682 Karvinen, 2009, PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries, Eur J Clin Invest, 39, 320, 10.1111/j.1365-2362.2009.02095.x Rubin, 1988, Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions, Lancet, 1, 1353, 10.1016/S0140-6736(88)92177-0 Majesky, 1990, PDGF ligand and receptor gene expression during repair of arterial injury, J Cell Biol, 111, 2149, 10.1083/jcb.111.5.2149 Tanizawa, 1996, Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study, Heart, 75, 549, 10.1136/hrt.75.6.549 Ross, 1986, The biology of platelet-derived growth factor, Cell, 46, 155, 10.1016/0092-8674(86)90733-6 Green, 1996, Inhibitory DNA ligands to platelet-derived growth factor B-chain, Biochemistry, 35, 14413, 10.1021/bi961544+ Leppänen, 2000, Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model, Arterioscler Thromb Vasc Biol, 20, E89, 10.1161/01.ATV.20.11.e89 Cerchia, 2009, Cell-specific aptamers for targeted therapies, Methods Mol Biol, 535, 59, 10.1007/978-1-59745-557-2_5 Ray, 2013, Application of aptamers for targeted therapeutics, Arch Immunol Ther Exp (Warsz), 61, 255, 10.1007/s00005-013-0227-0 McNamara 2nd, 2006, Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras, Nat Biotechnol, 24, 1005, 10.1038/nbt1223 Dassie, 2009, Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors, Nat Biotechnol, 27, 839, 10.1038/nbt.1560 Thiel, 2012, Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers, Nucleic Acids Res, 40, 6319, 10.1093/nar/gks294 Dassie, 2014, Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen, Mol Ther, 22, 1910, 10.1038/mt.2014.117