Small Artery Remodeling: Current Concepts and Questions

Journal of Vascular Research - Tập 47 Số 3 - Trang 183-202 - 2010
Jeroen van den Akker1, Marieke J.C. Schoorl2, Erik N.T.P. Bakker3, Ed VanBavel3
1Dept. of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
2Other departments
3Amsterdam Cardiovascular Sciences

Tóm tắt

Blood flow regulation by small arteries and arterioles includes adaptation of both vascular tone and structure. It is becoming clear that tone and remodeling of resistance vessels are highly interrelated. Indeed, concepts pointing to continuous resistance artery adaptation and plasticity are emerging. The purpose of this review is to summarize such concepts and approaches related to vascular organization and remodeling, and to point out the missing links and possible directions for future research. We focus on the individual vessel level. Since several relevant studies are based on isolated vessels, we briefly re-iterate the available isobaric and isometric approaches. We further discuss the major elements of the small artery wall and their relation to the passive and active mechanical properties, as important determinants for vascular remodeling. The cytoskeletal elements and actin re-organization during remodeling are discussed, as well as the re-lengthening of smooth muscle cells during prolonged constriction. We then consider tone as major causal factors in remodeling and discuss the role of vessel wall inflammation. Finally, we illustrate examples of current quantitative, integrative approaches of small artery mechanosensing and adaptation that may lead to a physiomics description of small artery adaptation in health and in diseases such as hypertension.

Từ khóa


Tài liệu tham khảo

10.1097%2F00004872-200106000-00002

10.1161%2F01.CIR.0000151610.98409.2F

10.1161%2F01.RES.25.4.407

10.1161%2Fhy09t1.096249

10.1038%2F260617a0

10.1007%2FBF02087051

10.1161%2F01.RES.41.1.19

10.1085%2Fjgp.74.1.85

10.1016%2F0160-5402%2890%2990032-G

10.1073%2Fpnas.0500058102

10.1113%2Fexpphysiol.2005.030056

10.1152%2Fajpheart.00838.2005

10.1002%2Fbdrc.20111

10.1016%2FS0369-8114%2801%2900151-1

10.1038%2F209399b0

10.1038%2F1971297a0

10.1679%2Faohc.65.109

10.1016%2FS0065-3233%2805%2970013-9

10.1021%2Fbi971036f

10.1016%2Fj.pharmthera.2005.12.003

10.1159%2F000113599

10.1023%2FA%3A1023422925910

10.1016%2FS0300-9084%2899%2900221-7

10.1023%2FA%3A1023474909980

10.1002%2Fbip.1974.360130404

10.1073%2Fpnas.84.16.5680

10.1007%2FBF00305723

10.1016%2FS0968-4328%2802%2900033-1

10.1073%2Fpnas.51.5.871

10.1073%2Fpnas.0502718103

10.2174%2F1381612054367544

10.1016%2Fj.cardiores.2005.12.010

10.1515%2FBC.2004.031

10.1016%2F0021-9290%2895%2900110-7

10.1016%2FS0006-3495%2897%2978783-6

10.1098%2Frstb.2001.1033

10.1038%2F1761062a0

10.1006%2Fjsbi.1998.3966

10.1016%2F0021-9290%2896%2900024-3

10.1016%2Fj.actbio.2004.09.007

10.1016%2Fj.biomaterials.2007.11.007

10.1107%2FS0909049505012549

10.1529%2Fbiophysj.108.131136

10.1111%2Fj.1440-1681.1992.tb00420.x

10.1088%2F0031-9155%2F40%2F10%2F002

10.1113%2Fjphysiol.2003.046904

10.1161%2F01.RES.73.6.1040

10.1016%2FS0021-9290%2802%2900444-X

10.1115%2F1.2798291

10.1114%2F1.191

10.1016%2F0026-2862%2882%2990016-4

10.1006%2Fexmp.1997.2217

10.1113%2Fexpphysiol.2005.030130

10.1006%2Fmvre.1996.1999

10.3171%2Fjns.1990.73.1.0082

10.1242%2Fjcs.02368

10.1111%2Fj.1582-4934.2008.00552.x

10.1254%2Fjphs.CP0070027

10.1139%2Fy05-016

10.1139%2Fy05-090

10.1529%2Fbiophysj.107.113977

10.1513%2Fpats.200705-056VS

10.1016%2FS1569-9048%2803%2900144-7

10.1152%2Fajpheart.91437.2007

10.1152%2Fajpcell.00253.2008

10.1152%2Fajpheart.00608.2004

10.1002%2F%28SICI%291097-0185%28199704%29247%3A4%3C439%3A%3AAID-AR1%3E3.0.CO%3B2-M

10.1113%2Fjphysiol.2001.014910

10.1159%2F000102277

10.1042%2FBJ20050065

10.1074%2Fjbc.M607715200

10.1046%2Fj.1356-9597.2001.00504.x

10.1152%2Fajplung.00199.2006

10.1152%2Fajpcell.00097.2006

10.1152%2Fajpcell.00154.2007

10.1016%2Fj.tcb.2006.03.003

10.1074%2Fjbc.M413390200

10.1113%2Feph8602217

10.1007%2Fs00249-008-0321-0

10.1152%2Fajpcell.00098.2008

10.1073%2Fpnas.92.22.10252

10.1089%2Ften.2006.0424

10.1242%2Fjcs.00359

10.1023%2FB%3AJURE.0000035898.10847.a1

10.1097%2F01.crd.0000200895.60631.0b

10.1007%2FBF02363920

10.1161%2F01.RES.82.2.210

10.1016%2FS0024-3205%2899%2900349-5

10.1159%2F000048989

10.1159%2F000077288

10.1161%2F01.CIR.0000095031.51492.C5

10.1097%2FHJH.0b013e32805bf8ed

10.1126%2Fscience.3941904

10.1172%2FJCI1699

10.1161%2F01.RES.0000047505.11002.81

10.1038%2Fnm1338

10.1161%2F01.RES.0000151333.56089.66

10.1161%2F01.RES.0000229657.83816.a7

10.1159%2F000109073

10.1159%2F000106465

10.1161%2FATVBAHA.108.166405

10.1161%2F01.ATV.0000069625.11230.96

10.1016%2FS0008-6363%2800%2900206-6

10.1016%2FS0021-9150%2801%2900637-2

10.1161%2FATVBAHA.107.151407

10.1093%2Fcvr%2Fcvn050

10.1016%2FS0303-7207%2801%2900703-1

10.1016%2Fj.placenta.2006.01.009

10.1152%2Fajpheart.01118.2006

10.1161%2F01.ATV.0000181743.28028.57

10.1152%2Fajpheart.00262.2008

10.1016%2Fj.tips.2007.05.006

10.1177%2F1753944707086358

10.1098%2Frsta.2008.0075

10.1007%2Fs11517-006-0139-9

10.1007%2FBF02344722

10.1159%2F000080699

10.1016%2Fj.jbiomech.2008.11.011

Thông tin
Thông tin xuất bản

Journal of Vascular Research

Tập 47 Số 3

183-202

Thông tin tác giả