Skeletal muscle hypertrophy and anti‐atrophy effects of clenbuterol are mediated by the β2‐adrenergic receptor

Muscle and Nerve - Tập 25 Số 5 - Trang 729-734 - 2002
Richard T. Hinkle1, Karen M. Hodge1, David B. Cody1, Russell J. Sheldon1, Brian K. Kobilka2, Robert J. Isfort1
1Research Division, Procter & Gamble Pharmaceuticals, 8700 Mason‐Montgomery Road, Mason, Ohio 45040‐9317, USA
2Howard Hughes Medical Institute, Stanford University, Stanford, California, USA

Tóm tắt

AbstractAnalyses were performed to evaluate the roles of the β1‐ and β2‐adrenergic receptors in the skeletal muscle hypertrophy and anti‐atrophy response to the β‐adrenergic agonist, clenbuterol. Treatment of wild‐type mice with clenbuterol resulted in statistically significant hypertrophy of the innervated tibialis anterior and medial gastrocnemius muscles and inhibition of denervation‐induced atrophy of these muscles. Treatment of β1‐adenergic receptor knockout mice with clenbuterol also resulted in statistically significant hypertrophy of the innervated tibialis anterior and medial gastrocnemius muscles and inhibition of denervation‐induced atrophy of these muscles. In contrast, in β2‐adrenergic receptor knockout mice and in mice lacking both the β1‐ and β2‐adrenergic receptors, clenbuterol treatment did not result in hypertrophy of the innervated tibialis anterior and medial gastrocnemius muscles, nor did it inhibit denervation‐induced atrophy in these muscles. Together these data demonstrate that the β2‐adrenergic receptor is responsible for both the skeletal muscle hypertrophy and anti‐atrophy effects of the β‐adrenergic agonist clenbuterol. © 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000–000, 2002

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Muscle and Nerve

Tập 25 Số 5

729-734

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