Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women
Tóm tắt
Cardiovascular disease is the major cause of death in the Western world, but some recent studies indicate that vitamin K may play a role in atherosclerosis protection. The aim of this study was to evaluate the effect of phylloquinone supplementation on blood lipids, inflammatory markers and fibrinolytic activity in postmenopausal women. Thirty-one postmenopausal women completed this placebo-controlled, randomized crossover study and received 500 µg phylloquinone or placebo in addition to their habitual diet during two periods of 6 weeks’ duration. Blood concentration of lipids, inflammatory markers and fibrinolytic parameters were measured after each period. Inflammatory markers, fibrinolytic parameters, total cholesterol and LDL-C were unaffected by the supplementation, whereas a 15% increase was seen in triacylglycerols (P = 0.015) and a 5% decrease in HDL-C (P = 0.06). Six weeks supplementation with a dose of phylloquinone similar to that obtainable from the diet induced a deterioration of the lipid profile with no improvement in any of the other risk markers analysed. Thus, these results do not support a cardioprotective effect of vitamin K as has been suggested by others.
Tài liệu tham khảo
Booth SL, Martini L, Peterson JW, Saltzman E, Dallal GE, Wood RJ (2003) Dietary phylloquinone depletion and repletion in older women. J Nutr 133: 2565–2569
Braam L, Hoeks APG, Brouns F, Hamulyak K, Gerichhausen MJW, Vermeer C (2004) Beneficial effects of vitamins D and K in the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost 91:373–380
Bugel S, Sorensen AD, Hels O, Kristensen M, Vermeer C, Jakobsen J, Flynn A, Molgaard C, Cashman KD (2007) Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Br J Nutr 97:373–380
Eichbaum FW, Slemer O, Zyngier SB (1979) Anti-inflammatory effct of warfarin and vitamin k1. Naunyn Schmiedebergs Arch Pharmacol 307:185–190
Geleijnse JM, Vermeer C, Schurgers LJ, Grobbee HAP, Witteman, Jacqueline CM (2001) Inverse association of dietary vitamin K2 intake with cardiac events and aortic atherosclerosis: the Rotterdam study. J Thromb Haemost Suppl. Ref type: abstract
Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MHJ, van der Meer IM, Hofman A, Witteman JCM (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam study. J Nutr 134:3100–3105
Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, Heimovitz H, Cohen HJ, Wallace R (1999) Associations of elevated Interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 106:506–512
Hokanson JE, Austin MA (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 3:213–219
Jono S, Ikari Y, Vermeer C, Dissel P, Hasegawa K, Shioi A, Taniwaki H, Kizu A, Nishizawa Y, Saito S (2004) Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb Heamost 91:790–794
Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukata T, Mizuno S, Tkahashi S, Tajima T, Nakamura T (1997) Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol 75:135–143
Nagasawa Y, Fujii M, Kajimoto Y, Imai E, Hori M (1998) Vitamin K2 and serum cholesterol in patients on continuous ambulatory peritoneal dialysis. Lancet 351:724
Reddi K, Henderson B, Meghji S, Wilson M, Poole S, Hopper C, Harris M, Hodges SJ (1995) Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by Naphthoquinone (vitamin K) compounds. Cytokine 7:287–290
Ridker PM, Hennekens CH, Buring JE, Rifai N (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836–843
Ridker PM, Rifai N, Stampfer MJ, Hennekens CH (2000) Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101:1767–1772
Seyama Y, Hayashi M, Takegami H, Usami E (1999) Comparative effects of vitamin K2 and vitamin E on experimental atheriosclerosis. Int J Vit Nutr Res 69:23–26
Shea MK, Booth SL, Massaro JM, Jacques PF, D’Agostino RB Sr, wson-Hughes B, Ordovas JM, O’Donnell CJ, Kathiresan S, Keaney JF Jr, Vasan RS, Benjamin EJ (2008) Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham offspring study. Am J Epidemiol 167:313–320
Spronk HMH, Soute BAM, Schurgers LJ, Thijssen HHW, De Mey JGR, Vermeer C (2003) Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res 40:531–537
Villines TC, Hatzigeorgiou C, Feuerstein IM, O’Malley PG, Taylor AJ (2005) Vitamin K1 intake and coronary calcification. Coron Artery Dis 16:199–203
Willerson JT, Ridker PM (2004) Inflammation as a cardiovascular risk factor. Circulation 109:II-2–II-10