Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone

American Association for the Advancement of Science (AAAS) - Tập 349 Số 6253 - Trang 1224-1228 - 2015
Warren Lau1, Elizabeth S. Sattely1
1Department of Chemical Engineering, Stanford University, Stanford, CA 94305 USA

Tóm tắt

Transplanting the wisdom of the mayappleEtoposide, a topoisomerase inhibitor, is used to treat various cancers. However, etoposide isn't that easy to get. Its precursor comes from the very slow-growing mayapple plant. Lau and Sattely used bioinformatics, heterologous enzyme expression, and kinetic characterization, to work out the pathway that makes the precursor in mayapple (see the Perspective by O'Connor). They then successfully transplanted the full biosynthetic pathway into tobacco plants.Science, this issue p.1224; see also p.1167

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