Six‐Month Follow‐Up of Short‐Term Pharmacotherapy for Cocaine Dependence

American Journal on Addictions - Tập 1 Số 1 - Trang 40-49 - 1992
Thomas R. Kosten1,2, Frank H. Gawin1,2, Therese A. Kosten1,2, Cindy Morgan1,2, Bruce J. Rounsaville1,2, Richard S. Schottenfeld1,2, Herbert D. Kleber1,2
1Department of Psychiatry, University of California at Los Angeles.
2Substance Abuse Treatment Unit, Department of Psychiatry, Yale University School of Medicine, New Haven

Tóm tắt

This 6‐month follow‐up study of 43 of 72 patients who entered a 6‐week randomized clinical trial of pharmacotherapy for cocaine dependence found that self‐reported cocaine abstinence during the 6 months was significantly greater in patients treated with desipramine (44%) than in those treated with lithium (19%) or placebo (27%). The placebo group had more occurrences of depression (36% vs. 6%) and daily alcohol abuse (36% vs. 15%) than the medicated groups. The ability to abstain from cocaine use during the clinical trial was the strongest predictor of continued abstinence during the follow‐up, which showed that 53% remained abstinent after 6 months.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

American Journal on Addictions

Tập 1 Số 1

40-49

Thông tin tác giả