Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor

Springer Science and Business Media LLC - Tập 10 - Trang 1-2 - 2013
Angela Corona1, Rita Meleddu1, Francesca Esposito1, Simona Distinto1, Giulia Bianco1, Elias Maccioni1, Stuart SF Le Grice2, Enzo Tramontano1
1Department of Life and Environmental Sciences, University of Cagliari, Cagliari, ltaly
2National Cancer Institute, Frederick, USA

Tài liệu tham khảo

Distinto S, Maccioni E, Meleddu R, Corona A, Alcaro S, Tramontano E: Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors. Curr Pharm Des. 2013, 19: 1850-1859. 10.2174/1381612811319100009. Distinto S, Esposito F, Kirchmair J, Cardia MC, Gaspari M, Maccioni e, Alcaro S, Markt P, Wolber G, Zinzula L, Tramontano E: Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach. Eur J Med Chem. 2012, 50: 216-229.