Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

Oxidative Medicine and Cellular Longevity - Tập 2017 Số 1 - 2017
Weijin Zhang1,2, Qiaobing Huang2, Zhenhua Zeng1,2, Jie Wu1,2, Yaoyuan Zhang1, Zhongqing Chen1,2
1Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
2Guangdong Key Lab of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China

Tóm tắt

The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a barrier that mediates microenvironment homeostasis. Deterioration of either the structure or function of endothelial cells (ECs) results in a variety of cardiovascular diseases. Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction. The longevity regulator Sirt1 is a NAD+‐dependent deacetylase that has a potential antioxidative stress activity in vascular ECs. The mechanisms underlying the protective effects involve Sirt1/FOXOs, Sirt1/NF‐κB, Sirt1/NOX, Sirt1/SOD, and Sirt1/eNOs pathways. In this review, we summarize the most recent reports in this field to recapitulate the potent mechanisms involving the protective role of Sirt1 in oxidative stress and to highlight the beneficial effects of Sirt1 on cardiovascular functions.

Từ khóa


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Oxidative Medicine and Cellular Longevity

Tập 2017 Số 1

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