Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

American Association for the Advancement of Science (AAAS) - Tập 360 Số 6390 - Trang 758-763 - 2018
Jihwan Park1, Rojesh Shrestha1, Chengxiang Qiu1, Ayano Kondo1, Shizheng Huang1, Max Werth2, Mingyao Li3, Jonathan Barasch2, Katalin Suszták1
1Renal Electrolyte and Hypertension Division, Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Renal Division, Department of Medicine, Columbia University, New York, NY 10032, USA.
3Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Tóm tắt

Touring the kidney, cell by cell Our kidneys play a critical role in keeping us healthy, a fact of which we are reminded several times each day. This organ's cellular complexity has hindered progress in understanding the mechanisms underlying chronic kidney disease, which affects 10% of the world's population. Using single-cell transcriptional profiling, Park et al. produced a comprehensive cell atlas of the healthy mouse kidney (see the Perspective by Humphreys). An unexpected cell type in the collecting duct appears to be a transitional state between two known cell types. The transition from one cell type to the other is regulated by the Notch signaling pathway and is associated with metabolic acidosis. The authors also find that genetically distinct kidney diseases with common clinical features share common cellular origins. Science , this issue p. 758 ; see also p. 709

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American Association for the Advancement of Science (AAAS)

Tập 360 Số 6390

758-763

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