Anoop P. Patel1,2,3,4, Itay Tirosh1, John J. Trombetta1, Alex K. Shalek1, Shawn Gillespie1,3,4, Hiroaki Wakimoto2, Daniel P. Cahill2, Brian V. Nahed2, William T. Curry2, Robert L. Martuza2, David N. Louis3, Orit Rozenblatt‐Rosen1, Mario L. Suvà1,3, Aviv Regev1,5,4, B Bernstein1,3,4
1Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
2Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
3Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
4Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA
5Department of Biology, MIT, Cambridge, MA 02139, USA
Tóm tắt
Cancer at single-cell resolution
Single-cell sequencing can illuminate the genetic properties of brain cancers and reveal heterogeneity within a tumor. Patel
et al.
examined the genome sequence of single cells isolated from brain glioblastomas. The findings revealed shared chromosomal changes but also extensive transcription variation, including genes related to signaling, which represent potential therapeutic targets. The authors suggest that the variation in tumor cells reflects neural development and that such variation among cancer cells may prove to have clinical significance.
Science
, this issue p.
1396
