Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning

Learning and Memory - Tập 13 Số 2 - Trang 201-207 - 2006
Amy G. Kuo1, Grace Lee2, John F. Disterhoft1
1Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
2University of Wisconsin, Madison, Wisconsin 53706, USA

Tóm tắt

A common cellular alteration, reduced post-burst afterhyperpolarization (AHP) in CA1 neurons, is associated with acquisition of the hippocampus-dependent tasks trace eyeblink conditioning and the Morris water maze. As a similar increase in excitability is correlated with these two learning paradigms, we sought to determine the interactive behavioral effects of training animals on both tasks by using either a consecutive or simultaneous training design. In the consecutive design, animals were trained first on either the trace eyeblink conditioning task for six sessions, followed by training on the water maze task for six sessions, or vice versa. The simultaneous design consisted of six or 11 training days; animals received one session/day of both trace eyeblink conditioning and water maze training. Separate groups were used for consecutive and simultaneous training. Animals trained on both tasks simultaneously were significantly facilitated in their ability to acquire the trace eyeblink conditioning task; no effect of simultaneous training was seen on the water maze task. No effect was seen on acquisition for either task when using the consecutive training design. Taken together, these findings provide insight into how the hippocampus processes information when animals learn multiple hippocampus-dependent tasks.

Từ khóa


Tài liệu tham khảo

10.1037/0735-7044.113.6.1170

Barnes, 1994, LTP saturation and spatial learning disruption: Effects of task variables and saturation levels., J. Neurosci., 14, 5793, 10.1523/JNEUROSCI.14-10-05793.1994

10.1126/science.6324350

10.1016/0006-8993(78)90510-3

10.1126/science.1257783

10.1038/342545a0

10.1101/lm.59603

10.1016/0163-1047(93)90925-8

10.1016/S0024-3205(98)00599-2

10.1002/(SICI)1096-9861(20000131)417:1<49::AID-CNE4>3.0.CO;2-3

10.1002/hipo.10159

10.1037/0735-7044.111.5.1031

Kuo A.G. Lee G. Disterhoft J.F. 2004 Alteration of sIAHP underlies reduction of AHP in rat CA1 pyramidal neurons after trace eyeblink conditioning. Soc. Neurosci. Abstr. 741: 13.

10.1073/pnas.85.5.1672

10.1002/(SICI)1098-1063(1998)8:6<638::AID-HIPO6>3.0.CO;2-Q

McNaughton, 1986, Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information., J. Neurosci., 6, 563, 10.1523/JNEUROSCI.06-02-00563.1986

10.1038/297681a0

10.1101/lm.1.1.55

10.1126/science.281.5385.2038

10.1037/0735-7044.104.2.243

Moyer Jr., 1996, Trace eyeblink conditioning increases CA1 excitability in a transient and learning-specific manner., J. Neurosci., 16, 5536, 10.1523/JNEUROSCI.16-17-05536.1996

10.1523/JNEUROSCI.1725-04.2004

Oh, 1999, Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus., J. Neurosci., 19, 1814, 10.1523/JNEUROSCI.19-05-01814.1999

10.1152/jn.01177.2002

Power, 1997, Enhanced synaptic transmission in CA1 hippocampus after eyeblink conditioning., J. Neurophysiol., 78, 1184, 10.1152/jn.1997.78.2.1184

10.1002/hipo.450050303

10.1016/0166-4328(89)90010-7

10.1046/j.1460-9568.1998.00149.x

Schwindt, 1988, Multiple potassium conductances and their functions in neurons from cat sensorimotor cortex in vitro., J. Neurophysiol., 59, 424, 10.1152/jn.1988.59.2.424

Skelton, 1987, Long-term increases in dentate granule cell responsivity accompany operant conditioning., J. Neurosci., 7, 3081, 10.1523/JNEUROSCI.07-10-03081.1987

10.1002/(SICI)1098-1063(1999)9:2<118::AID-HIPO4>3.0.CO;2-8

10.1016/S0079-6123(08)61248-0

10.1037/0735-7044.116.2.351

10.1016/S0166-4328(98)00096-5

10.1037/0735-7044.113.5.1100

Weiss, 2000, The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons., J. Neurosci., 20, 783, 10.1523/JNEUROSCI.20-02-00783.2000

10.1016/0166-4328(84)90037-8

Thông tin
Thông tin xuất bản

Learning and Memory

Tập 13 Số 2

201-207

Thông tin tác giả