Simple Method for the Esterification of Carboxylic Acids

Wiley - Tập 17 Số 7 - Trang 522-524 - 1978
Bernhard Neises1, Wölfgang Steglich1
1Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Strasse 1, D-5300 Bonn (Germany)

Tóm tắt

Addition of 4‐dimethylaminopyridine (DMAP) accelerates the dicyclohexylcarbo‐diimide (DCC)‐activated esterification of carboxylic acids to such an extent that side reactions are eliminated and even sensitive acids such 2,5‐cyclohexadiene‐1‐carboxylic acid readily form the tert‐butyl ester. DMAP has so far been used mainly as acylation catalyst. equation image

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Tài liệu tham khảo

4‐Dialkylaminopyridines as Acylation Catalysts Part 5.–Part 4:G.Höfle W.Steglich H.Vorbrüggen Angew. Chem. and Angew. Chem. Int. Ed. Engl. in press.—

We thank Prof.VorbrüggenSchering AG Berlin for supplying the 4‐dimethylaminopyridine.

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