Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Takeuchi, 1999, Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components, Immunity, 11, 443, 10.1016/S1074-7613(00)80119-3

Schnare, 2001, Toll-like receptors control activation of adaptive immune responses, Nat. Immunol., 2, 947, 10.1038/ni712

Vasselon, 2002, Toll receptors: a central element in innate immune responses, Infect. Immun., 70, 1033, 10.1128/IAI.70.3.1033-1041.2002

Shuto, 2001, Activation of NF-kB by nontypeable Hemophilus influenzae is mediated by Toll-like receptor 2-TAK1-dependent NIK-IKKa/b-IkBa and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells, Proc. Natl. Acad. Sci. USA, 98, 8774, 10.1073/pnas.151236098

Jiang, 2002, Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol, Mol. Cell. Biol., 22, 7158, 10.1128/MCB.22.20.7158-7167.2002

Yamamoto, 1988, In vitro augmentation of natural killer cell activity and production of interferon-a/b and -g with deoxyribonucleic acid fraction from Mycobacterium bovis BCG, Jpn. J. Cancer Res., 79, 866, 10.1111/j.1349-7006.1988.tb00049.x

Krieg, 1995, CpG motifs in bacterial DNA trigger direct B-cell activation, Nature, 374, 546, 10.1038/374546a0

Klinman, 1996, CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon g, Proc. Natl. Acad. Sci. USA, 93, 2879, 10.1073/pnas.93.7.2879

Hacker, 2000, Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6, J. Exp. Med., 192, 595, 10.1084/jem.192.4.595

Hemmi, 2000, A Toll-like receptor recognizes bacterial DNA, Nature, 408, 740, 10.1038/35047123

Takeshita, 2001, Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells, J. Immunol., 167, 3555, 10.4049/jimmunol.167.7.3555

Klinman, 2002, CpG DNA: recognition by and activation of monocytes, Microbes Infect., 4, 897, 10.1016/S1286-4579(02)01614-3

Ahmad-Nejad, 2002, Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments, Eur. J. Immunol., 32, 1958, 10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U

Bauer, 2001, Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition, Proc. Natl. Acad. Sci. USA, 98, 9237, 10.1073/pnas.161293498

Horng, 2002, The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors, Nature, 420, 329, 10.1038/nature01180

Yamamoto, 2002, Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Nature, 420, 324, 10.1038/nature01182

Yamamoto, 2002, Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-b promoter in the Toll-like receptor signaling, J. Immunol., 169, 6668, 10.4049/jimmunol.169.12.6668

Hacker, 1999, Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells, EMBO J., 18, 6973, 10.1093/emboj/18.24.6973

Yi, 2002, Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response, J. Immunol., 168, 4711, 10.4049/jimmunol.168.9.4711

Hartmann, 2000, Mechanism and function of a newly identified CpG DNA motif in human primary B cells, J. Immunol., 164, 944, 10.4049/jimmunol.164.2.944

Yi, 1998, Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA, J. Immunol., 161, 4493, 10.4049/jimmunol.161.9.4493

Hacker, 1998, CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation, EMBO. J., 17, 6230, 10.1093/emboj/17.21.6230

Takeshita, 2000, Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression, Eur. J. Immunol., 30, 108, 10.1002/1521-4141(200001)30:1<108::AID-IMMU108>3.0.CO;2-4

Takeshita, 2000, CpG ODN-mediated regulation of IL-12 p40 transcription, Eur. J. Immunol., 30, 1967, 10.1002/1521-4141(200007)30:7<1967::AID-IMMU1967>3.0.CO;2-5

Hoshino, 2002, Differential involvement of IFN-b in Toll-like receptor-stimulated dendritic cell activation, Int. Immunol., 14, 1225, 10.1093/intimm/dxf089

Ishii, 2002, Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation, J. Exp. Med., 196, 269, 10.1084/jem.20020773

Yi, 1998, CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species, J. Immunol., 160, 4755, 10.4049/jimmunol.160.10.4755

Chu, 2000, DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA, Cell, 103, 909, 10.1016/S0092-8674(00)00194-X

Backer, 2000, Phosphoinositide 3-kinases and the regulation of vesicular trafficking, Mol. Cell. Biol. Res. Commun., 3, 193, 10.1006/mcbr.2000.0202

Siddhanta, 1998, Distinct roles for the p110a and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis, J. Cell. Biol., 143, 1647, 10.1083/jcb.143.6.1647

Vieira, 2002, Phagosome maturation: aging gracefully, Biochem. J., 366, 689, 10.1042/bj20020691

Ozes, 1999, NF-kB activation by tumour necrosis factor requires the Akt serine-threonine kinase, Nature, 401, 82, 10.1038/43466

Vanhaesebroeck, 2000, The PI3K-PDK1 connection: more than just a road to PKB, Biochem. J., 346, 561, 10.1042/0264-6021:3460561

Arbibe, 2000, Toll-like receptor 2-mediated NF-kB activation requires a Rac1-dependent pathway, Nat. Immunol., 1, 533, 10.1038/82797

Park, 2002, Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3′-OH kinase pathway, J. Immunol., 168, 5, 10.4049/jimmunol.168.1.5

Kadowaki, 2001, Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens, J. Exp. Med., 194, 863, 10.1084/jem.194.6.863

Zarember, 2002, Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines, J. Immunol., 168, 554, 10.4049/jimmunol.168.2.554

Hornung, 2002, Quantitative expression of Toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides, J. Immunol., 168, 4531, 10.4049/jimmunol.168.9.4531

An, 2002, Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kB, ERK and p38 MAPK signal pathways, Immunol. Lett., 81, 165, 10.1016/S0165-2478(02)00010-X

Sweet, 2002, Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of Toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages, J. Immunol., 168, 392, 10.4049/jimmunol.168.1.392