Signal Transduction Pathways Mediated by PECAM-1

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 23 Số 6 - Trang 953-964 - 2003
Peter J. Newman1, Debra K. Newman1
1From the Blood Research Institute, The Blood Center of Southeastern Wisconsin (P.J.N., D.K.N.), and the Departments of Pharmacology (P.J.N.), Cellular Biology (P.J.N.), and Microbiology (D.K.N.) and Cardiovascular Center (P.J.N.), Medical College of Wisconsin, Milwaukee, Wis.

Tóm tắt

Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient mice have revealed that this molecule plays an important role in controlling the activation and survival of cells on which it is expressed. In this review, we focus on the complex cytoplasmic domain of PECAM-1 and describe what is presently known about its structure, posttranslational modifications, and binding partners. In addition, we summarize findings that implicate PECAM-1 as an inhibitor of cellular activation via protein tyrosine kinase–dependent signaling pathways, an activator of integrins, and a suppressor of cell death via pathways that depend on damage to the mitochondria. The challenge of future research will be to bridge our understanding of the functional and biochemical properties of PECAM-1 by establishing mechanistic links between signals transduced by the PECAM-1 cytoplasmic domain and discrete cellular responses.

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Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 23 Số 6

953-964

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