Side Effects of Antibiotics on Immune Response Parameters and their Possible Implications in Antimicrobial Chemotherapy

G. Gillissen1
1Institute of Medical Microbiology, Medical Faculty, Rheinisch-Westfälische Technische Hochschule, D-5100 Aachen

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Adam, 1971, Studies on the influence of host defence mechanisms on the antimicrobial effect of chemotherapeutic agents. Effect of antibiotics on phagocytosis of mouse-peritoneal-macrophages in vitro, Ärztl. Forsch., 25, 181 Adam, 1972, Effect of Dihydrostreptomycin on phagocytosis of mouse-peritoneal-macrophages in vitro, Infect. Immun., 5, 537, 10.1128/IAI.5.4.537-541.1972 Albert, 1978, Long term therapy with rifampicin and the secondary antibody response to killed influenza vaccine, Am. Rev. Resp. Dis., 117, 605 Alexander, 1975, Antibiotic agents and the immune mechanisms of defense, Bull. N. Y. Acad. Med., 51, 1039 Alkan, 1978, Excretion of lipoteichoic acid by group A streptococci; influence of penicillin on excretion and loss of ability to adhere to human oral mucosal cells, J. Clin. Invest., 61, 671, 10.1172/JCI108979 Allison, 1978, Mechanisms by which activated macrophages inhibit lymphocyte responses, Immunol. Rev., 40, 3, 10.1111/j.1600-065X.1978.tb00399.x Amoral, 1978, In vitro immunological responses to fosfomycin-induced abnormal forms of Salmonella typhimurium, Drugs Under Exp. Clin. Res., 4, 53 Anderson, 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte function in vitro. In vivo effects of co-trimoxazole. Antimicrob, Agents Chemother., 17, 322, 10.1128/AAC.17.3.322 Arvilommi, 1972, Immunosuppression by cotrimoxazole. (Letter), Br. Med. J., 3, 761, 10.1136/bmj.3.5829.761-b Arvilommi, 1976, Sulfamethoxazole-trimethoprim: Effect on antibody response in man, Chemotherapy, 22, 37, 10.1159/000221908 Banck, 1979, Antibiotics and suppression of lymphocyte function in vitro, Antimicrob. Agents Chemother., 16, 554, 10.1128/AAC.16.5.554 Becker, 1974, Comparative effects of thiamphenicol and chloramphenicol on haemopoiesis and lymphocyte transformation in vitro in man, Postgrad. Med. J., 50, 88 Belsheim, 1979, Tetracyclines and host defense mechanisms: Interference with leukocyte Chemotaxis, Scand. J. Infect. Dis., 11, 141, 10.3109/inf.1979.11.issue-2.08 Berry, 1949, Phagocytosis, Medicine, 28, 239, 10.1097/00005792-194909000-00001 Best, 1970, Evidence for participation of autolysis in bactericidal action of oxacillin on Staphylococcus aureus, Antimicrob. Agents Chemother., 6, 825, 10.1128/AAC.6.6.825 Bicker, 1975, Carcinostatic action of 2-cyana-ziridines against a sarcoma in rats, Exp. Path., 10, 279 Bistoni, 1987, Amphotericin-B induced immuno-modulation of resistance against Candida albicans infection, 91 Björksten, 1976, Inhibition of human neutrophil Chemotaxis and chemiluminescence by amphotericin B, Infect. Immun., 14, 315, 10.1128/IAI.14.1.315-317.1976 Blanke, 1977, Augmentation of murine immune responses by amphotericin B, Cell. Immunol., 33, 180, 10.1016/0008-8749(77)90145-9 Bodey, 1975, Infections in cancer patients, Cancer Treat. Rev., 2, 89, 10.1016/S0305-7372(75)80005-3 Bodey, 1966, Quantitative relationship between circulating leukocytes and infection in patients which acute leukemia, Am. Intern. Med., 64, 328, 10.7326/0003-4819-64-2-328 Bourne, 1974, Modulation of inflammation and immunity by cyclic AMP, Science, 184, 19, 10.1126/science.184.4132.19 Bromberg, 1979, Receptors for prostaglandin E on human peripheral blood mononuclear cells, Clin. Res., 27, 321A Büscher, 1985, Chemiluminescence of macrophages induced by non-opsonized E. coli treated with subinhibitory concentrations of β-lactam antibiotics, 152 Büscher, 1988, Influence of antibiotic therapy of mice on the humoral immune response against sheep erythrocytes (SRBC) Chan, 1978, Inhibition of granulocyte phagocytosis of Candida albicans by amphotericin B, Can. J. Microbiol., 24, 363, 10.1139/m78-061 Chaperon, 1982, Suppression of lymphocytes by cephalosporins, 22 Chaperon, 1978, Suppression of lymphocyte responses by cephalosporins, Infect. Immun., 19, 378, 10.1128/IAI.19.2.378-384.1978 Chaperon, 1988, Effects of β-lactam antibiotics on lymphocyte responses in vitro and in animals Clivio, 1978, In vitro effect of aminoglycoside antibiotics (gentamicin, sisomicin and netilmicin) on human leukocyte functions, IRCS Med. Sci., 6, 306 Clot, 1987, Stimulation of suppressor cell activity by Cefadroxil, 237 Clot, 1987, Stimulation of T-Suppressor cell activity by cephadroxil, Immun. Infekt., 5, 4 Cohen, 1985, Endotoxin release from bacteria exposed to ciprofloxacin and other bactericidal antibiotics Cuckler, 1955, The antimicrobial evaluation of oxamycin (D-4-amino-3-isoxazolidone), a new broad-spectrum antibiotic, Antibiot. Chemother., 5, 191 Dalhoff, 1985, Interaction of aminoglycosides and ciprofloxacin with bacterial membranes, 16 Dam, 1975, The effect of common antibiotics on lymphocyte transformation, Experientia, 31, 375, 10.1007/BF01922595 DaMert, 1979, Effect of chloramphenicol on in vitro function of lymphocytes, J. Infect. Dis., 139, 220, 10.1093/infdis/139.2.220 Daniel, 1965, Suppression of the anamnestic response to tetanus toxoid in man by chloramphenicol, N. Engl. J. Med., 173, 367, 10.1056/NEJM196508122730705 Downey, 1965, Some effect of antimicrobial compounds on phagocytosis in vitro, J. Reticuloendothel. Soc., 2, 75 Duguid, 1946, The sensitivity of bacteria to the action of penicillin, Edinburgh Med. J., 53, 401 Dutcher, 1978, Potentiaton of antibiotic bactericial activity by normal human serum, Antimicrob. Agents Chemother., 13, 820, 10.1128/AAC.13.5.820 Dziarski, 1981, Effects of staphylococcal cell wall products on immunity, 95 Eisenstein, 1980, Influence of sublethal concentrations of antibiotics on the expression of the mannose-specific ligand of Escherichia coli, Infect. Immun., 28, 154, 10.1128/IAI.28.1.154-159.1980 Eisenstein, 1978, Ribosomal misreading of mRNA prevents binding of Escherichia coli to mannose receptors on human epithelial cells, ASCI Infect. Dis. Clin. Res., 26, 523A Esterly, 1978, The effect of antimicrobial agents on leukocyte Chemotaxis, J. Invest. Dermatol., 70, 51, 10.1111/1523-1747.ep12543487 Ferrante, 1982, Inhibition of mitogen-induced human lymphocyte responsiveness by polymyxin antibiotics, Int. Arch. Allergy appl. Immun., 69, 279, 10.1159/000233184 Ferrante, 1980, The effect of amphotericin B treatment on Candida albicans-induced immunosuppression in mice, Immunol. Lett., 1, 321, 10.1016/0165-2478(80)90029-2 Ferrari, 1980, Inhibition of candidacidal activity of human neutrophil leukocytes by aminoglycoside antibiotics, Antimicrob. Agents Chemother., 17, 87, 10.1128/AAC.17.1.87 Fierer, 1979, Lethal effect of complement and lysozyme on polymyxin-treated, serumresistant gram-negative bacilli, J. Infect. Dis., 140, 581, 10.1093/infdis/140.4.581 Fieta, 1988, In vitro and ex vivo effect of cefodizime on phagocytosis Filice, 1986, Lack of synergy between phagocytes and antimicrobials against Nocardia asteroides, J. Antimicrob. Chemother., 17, 353, 10.1093/jac/17.3.353 Florey, 1949, Effects on morphology, 1144 Fontana, 1977, Penicillins activate autolysins extracted from both Escherichia coli and Klebsiella pneumoniae envelops, Antimicrob. Agents Chemother., 12, 745, 10.1128/AAC.12.6.745 Forsgren, 1978, Influence of antibiotics on lymphocyte function in vitro, Infection., 6, 91, 10.1007/BF01646075 Forsgren, 1980, Antibiotic-host defense interaction in vitro and in vivo, Scand. J. Infect. Dis., 24, 195 Forsgren, 1988, Quinolone antibiotics affect pyrimidine biosynthesis in human lymphocytes Forsgren, 1973, Tetracyclines and host-defence mechanisms, Antimicrob. Agents Chemother., 6, 711, 10.1128/AAC.3.6.711 Forsgren, 1977, Effect of antibiotics on Chemotaxis of human leukocytes, Antimicrob. Agents Chemother., 11, 580, 10.1128/AAC.11.4.580 Forsgren, 1978, Effect of antibiotics on Chemotaxis of human polymorphonuclear leukocytes in vitro, Infection 6, Suppl., 1, 102, 10.1007/BF01646077 Forsgren, 1974, Effect of tetracycline on the phagocytic function of human leukocytes, J. Infect. Dis., 130, 412, 10.1093/infdis/130.4.412 Friedman, 1985, Immunogenicity of bacteria treated in vitro with subinhibitory concentrations of antibiotics, 75 Friedman, 1985, Synergism between the host defense mechanisms and antibiotic treatment of bacteria, 105 Friedman, 1974, Enhanced susceptibility of penicillin resistant staphylococci to phagocytosis after in vitro incubation with low doses of nafcillin (38177), Proc. Soc. Exp. Biol. Med., 146, 707, 10.3181/00379727-146-38177 Friedman, 1987, Antibiotic modification of bacterial susceptibiltiy to host immunity, 73 Frugoni, 1954, Antibiotika und Immunität bei bakteriellen Infektionen, Sci. med., 3, 205 Gange, 1980, Neutrophil Chemotaxis in the presence of antibiotics: A Re-evaluation using an agarose technique, Br. J. Dermatol., 103, 51, 10.1111/j.1365-2133.1980.tb15837.x Gardner, 1940, Morphological effects of penicillin on bacteria, Nature, 146, 837, 10.1038/146837b0 Gaylarde, 1978, Suppression of thymidine uptake of human lymphocytes by Co-trimoxazole, Br. Med. J., 3, 144, 10.1136/bmj.3.5819.144 Gemmell, 1985, Elaboration of structural and soluble virulence factors by antibiotic-damaged bacteria. Consequences for host defenses, 179 Gemmell, 1985, In vivo consequences of the interaction between antibiotic damaged pathogens and host animal defences, 259 Gemmell, 1986, Direct and indirect effects of antibiotics on the phagocytic process, 111 Gemmell, 1987, Antibiotic-induced changes in the pathogenicity of bacteria and their influence on the interaction of bacteria with phagocytic cells in vitro and in vivo, 165 Gemmell, 1987, Interactions between bacterial pathogens, defence against infections and antibiotics in vitro and in vivo, Hyg. u. Med., 12, 46 Gemmell, 1988, An in vitro model to investigate the influence of antibiotics on bacterial susceptibility to surface phagocytosis by human polymorphonuclear leukocytes Gemmell, 1980, Antibiotic induced changes in streptococci with respect to their interaction with human polymorphonuclear leukocytes, Vol. II, 810 Gemmell, 1983, Regulation of protein A biosynthesis in Staphylococcus aureus by certain antibiotics: Its effect on phagocytosis by leukocytes, J. Antimicrob. Chemother., 12, 587, 10.1093/jac/12.6.587 Gemmell, 1981, Potentiation of opsonization and phagocytosis of Streptococcus pyogenes following growth in the presence of clindamycin, J. Clin. Invest., 67, 1249, 10.1172/JCI110152 Gemmell, 1976, The control of toxin and enzyme biosynthesis in staphylococci by antibiotics, 657 Gemsa, 1981, Prostaglandins and leukotrienes: Physiological and pathophysiological mediators of immunity, Behring Inst. Mitt., 68, 51 Ghione, 1987, The effect of some antibiotics on interferon production, 135 Gillissen, 1980, Antibiotika and Immunantwort — Begleiteffekte der Chemotherapie, Immun. Infekt., 8, 78 Gillissen, 1981, Non specific stimulation of immune defence as support of antimicrobial chemotherapy, Meth. Find. Exp. Clin. Pharmacol., 3, 297 Gillissen, 1981, The influence of sodium-8-chlorotheophyllinate (S8CT) on immune processes, Experientia, 37, 420, 10.1007/BF01959898 Gillissen, 1981, Nouveaux antibiotiques ²-lactam et reponse immunitaire, Med. et Hyg., 39, 122 Gillissen, 1982, Influence of cephalosporins on humoral immune response, 5 Gillissen, 1982, Non specific influence of antibiotics on the course of infectious processes, Infection, 10, 128, 10.1007/BF01640761 Gillissen, 1983, Interaktion zwischen Antibiotika und Immunabwehr, 58 Gillissen, 1984, Influence of cefaclor on immune response parameters, Arzneim. Forsch./Drug.Res., 34, 1535 Gillissen, 1985, Possible mechanisms of immunological side-effects of antibiotics, 91 Gillissen, 1987, Attempts to explain immunological side effects of antibiotics on the production of cellular mediators, 265 Gillissen, 1983, L’action additive d'un immunomodulateur sur l’effet thérapeutique des antibiotiques, Path. Biol., 6, 548 Gillissen, 1988, The immunomodulating effect of fosfomycin (FM) Gillissen, 1988, L’effet de la fosfomycine sur l’immunoréaction cellulaire sous l’influence da la cyclophosphamide ou des corticos-téroides, Path. Biol., 36, 731 Gillissen, 1985, Influence of subminimal inhibitory concentrations of antibiotics on antigen expression and metabloic activity of salmonella species, 84 Gillissen, 1984, Influence of antibiotics on immunological parameters: Significance in experimental infections, Drugs exp. clin. Res., X, 813 Gillissen, 1958, Die Beeinflussung der Phosphatasen von M. pyogenes var. aureus durch Penicillin und Neomycin, Z. Hyg., 144, 401, 10.1007/BF02161926 Gnarpe, 1978, Tetracyclines and host defence mechanisms: Doxycyc-linepolymethaphosphate sodium complex (DMSC) compared to doxycycline with regard to influence on some host defence mechanisms, Microbios, 22, 45 Gnarpe, 1984, The in vitro influence of ceftazidime on host defence mechanisms, J. Antimicrob. Chemother., 13, 369, 10.1093/jac/13.4.369 Gnarpe, 1987, Influence of different tetracyclines on granulocyte functions, 143 Gnarpe, 1974, Tetracycline and host defence mechanisms. Doxycycline interference with phagocytosis of Escherichia coli, Microbios, 10A, 127 Goldstein, 1976, Rifampin and cell-mediated immune response in tuberculosis, Am. Rev. Respir. Dis., 113, 197 Goodhart, 1977, Effect of aminoglycosides on the chemotactic response of human polymorphonuclear leukocytes, Antimicrob. Agents Chemother., 12, 540, 10.1128/AAC.12.4.540 Goodhart, 1979, Further evidence for the role of bivalent cations in human polymorphonuclear leukocyte locomotion: Recovery from tetracycline-induced inhibition by the presence of cation ionophores, J. Reticuleondothel. Soc., 25, 545 Goodwin, 1977, Suppression of human T-cell mitogenesis by prostaglandins, J. Exp. Med., 146, 1719, 10.1084/jem.146.6.1719 Goodwin, 1983, Regulation of the immune response by prostaglandins, J. Clin. Immunol., 3, 295, 10.1007/BF00915791 Goodwin, 1979, Cyclic adenosine monophosphate response to prostaglandin E2 on subpopulations of human lymphocytes, J. Exp. Med., 150, 1260, 10.1084/jem.150.5.1260 Goodwin, 1978, Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. Changes with mitogen dose and preincubation, J. Clin. Invest., 62, 753, 10.1172/JCI109186 Goodwin, 1979, High affinity binding sites for prostaglandin E on human lymphocytes, Cell. Immunol., 43, 150, 10.1016/0008-8749(79)90158-8 Graber, 1973, Light chain proteinuria and humoral immunoincompetence in tuberculous patients treated with rifampin, Am. Rev. Resp. Dis., 107, 713 Grassi, 1972, Effect of rifampicin on delayed-hypersensitivity reactions, J. Infect. Dis., 126, 542, 10.1093/infdis/126.5.542 Gray, 1980, Rifampin has paradoxical effects on leukotaxis, Fed. Proc., 39, 878 Gurwith, 1978, Granulocytopenia in hospitalized patients. I. Prognosis factors and etiology of fever, Am. J. Med., 64, 121, 10.1016/0002-9343(78)90187-0 Haas, 1978, Suppression of the immune response in C3H/HeJ mice by protein free lipopolysaccharides, J. Exp. Med., 148, 1081, 10.1084/jem.148.4.1081 Hadden, 1977, Cyclic nucleotides in lymphocyte proliferation and differentiation Hahn, 1986, Kurzmitteilung über den Einfluß von Chinolonabkömmlingen auf das Immunsystem, Infection, 14, 219, 10.1007/BF01667849 Hahn, 1987, Influence of the quinolones and tetracycline on specific T-cell-antigen interactions in vitro and on delayed type hypersensitivity to SRBC in mice, 225 Hahn, 1985, Influence of ciprofloxacin on specific interactions on Listerâ-specific T-cells with antigen in vitro, 96 Hammarström, 1976, Mitogenic properties of polyene antibiotics for murine B cells, Scand. J. Immunol., 5, 37, 10.1111/j.1365-3083.1976.tb02990.x Hand, 1988, Interactions between antibiotics, phagocytes and bacteria Hanehara, 1986, In vitro activity of cefodizime: Morphological alterations in Escherichia coli and Proteus vulgaris, 23 Hänel, 1986, The influence of the cephalosporin derivative cefodizime on the immune system evaluated in in vivo experiments, Immun. Infekt., 1, 24 Hänel, 1986, Influence of cefodizime (HR221) on an experimentally induced Candida vaginitis in rats, 31 Hauser, 1982, Effect of antibiotics on the immune response, Am. J. Med., 72, 711, 10.1016/0002-9343(82)90534-4 Hendlen, 1969, Fosfomycin, a new antibiotic produced by strains of Streptomyces, Science, 166, 122, 10.1126/science.166.3901.122 Henneberg, 1948, Die Wirkung der Penicillintherapie auf den Gehalt an komplementbindenden Antikörpern bei der Gonorrhoe, Arch. Derm., 187, 350, 10.1007/BF02116108 Henneberg, 1955, Chemotherapie, Immunität und Prophylaxe, Antibiot. Chemother., 2, 7 Henson, 1976, Membrane receptors on neutrophils, Immunol. Commun., 5, 757, 10.3109/08820137609047618 Hoeprich, 1970, Effect of tetracycline, polymyxin B and rifampin on phagocytosis, Clin. Pharmacol. Ther., 11, 418, 10.1002/cpt1970113418 Horn, 1988, Determination of intracellular antibacterial activity of chemotherapeutics by means of a fluorochrome miroassay Humber, 1980, Controlled double-blind study of the effect of rifampin and humoral and cellular immune responses in patients with pulmonary tuberculosis and in tuberculosis contacts, Am. Rev. Resp. Dis., 122, 425 Johnson, 1981, Microbial adjuvants and immune responsiveness, 1 Johnson, 1956, Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigen by purified lipopoly-saccharide, J. Exp. Med., 103, 225, 10.1084/jem.103.2.225 Johnson, 1980, Antibiotic uptake by alveolar macrophages, J. Lab. Clin. Med., 95, 429 Jones, 1972, Enhancing effects of bacterial endotoxins on bone marrow cells in the immune response to SRBC, J. Immunol., 108, 1453 Kadurugamuwa, 1985, Exposure of protein antigens and reduction of siderophore production after growth of gramnegative bacteria in subinhibitory concentrations of cephalosphorins, 36 Kahan, 1974, The mechanism of action of fosfomycin (Phosphomycin), Ann. N.Y. Acad. Sci., 235, 364, 10.1111/j.1749-6632.1974.tb43277.x Krach, 1985, Subinhibitory concentrations of antibiotics modulate amount of Shiga-like toxin production by Escherichia coli, 239 Khan, 1979, Abnormal neutrophil Chemotaxis and random migration induced by aminoglycoside antibiotics, J. Lab. Clin. Med., 93, 295 Klempner, 1981, Clindamycin uptake by human neutrophils, J. Infec. Dis., 144, 472, 10.1093/infdis/144.5.472 König, 1987, Die Bedeutung des Immunglobulin E für die Entzündungsreaktion und die Beeinflussung erhöhter IgE-Spiegel durch Cephadroxil, Immun. Infekt., 15, 2 Koretzky, 1983, Spontaneous production of interleukin-1 by human alveolar macrophages, Clin. Immunol. Immunopath., 29, 443, 10.1016/0090-1229(83)90047-8 Labor, 1988, Pseudomonas aeruginosa-alterations by low concentrations of quinolones: consequencies on neutrophil bactericidal functions Lagrange, 1988, Effects of selected antibiotis on experimental candidiasis in cyclophosphamide treated mice: an in vivo experimental model to evaluate the inhibitory effect of antibiotics on granulopoesis Lagrange, 1987, In vitro effects of subMIC's of antibiotics on the antigenicity and immunogenicity of Pseudomonas aeruginosa, 51 Lambe, 1987, The effect of subinhibitory concentrations of clindamycin on the adherence and glycocalyx of Staphylococcus aureus and Bacteroides species in vitro and in vivo, 35 Larson, 1980, Direct stimulation of lymphokine production by cephalothin, J. Infect. Dis., 142, 265, 10.1093/infdis/142.2.265 Lehrer, 1971, Inhibition by sulfonamides of the candidacidal activity of human neutrophils, J. Clin. Invest., 50, 2498, 10.1172/JCI106750 Lehrer, 1973, Effects of colchicine and chloramphenicol on the oxidative metabolism and phagocytic activity of human neutrophils, J. Infect. Dis., 127, 40, 10.1093/infdis/127.1.40 Leying, 1985, The influence of β-lactam antibiotics including monobactam on the outer and inner membrane of E. coli, 48 Leying, 1988, Influence of antibiotics on the cell surface of Escherichia coli Lipsky, 1976, Suppression of graft-versus-host reactions by D- and L-chloramphenicol, Cell. Immunol., 23, 278, 10.1016/0008-8749(76)90193-3 Little, 1978, Immunoadjuvant and antitumor properties of amphotericin B, 381 Little, 1987, Amphotericin B — a model murine immunostimulant, 253 Lobo, 1973, The effect of antibiotics on Escherichia coli ingested by macrophages, Proc. Soc. Exp. Biol., 142, 1048, 10.3181/00379727-142-37173 Lorian, 1975, Some effects of subinhibitory concentrations of penicillin on the structure and division of staphylococci, Antimicrob. Agents Chemother., 7, 864, 10.1128/AAC.7.6.864 Lorian, 1980, Effects of subminimum inhibitory concentrations of antibiotics on bacteria, 342 Lorian, 1976, Effects of subinhibitory concentrations of fosfomycin on bacteria, G. Ital. Chemioter., 23, 65 Lorian, 1979, Effect of serum and blood on Enterobacteriaceae grown in the presence of subminimal inhibitory concentrations of ampicillin and mecillinam, Rev. Infect. Dis., 1, 797, 10.1093/clinids/1.5.797 Lorian, 1976, Agglutination with O antisera of Salmonella exposed to antibiotics, Am. J. Clin. Path., 66, 1004, 10.1093/ajcp/66.6.1004 Lorian, 1972, The effect of nitrofurantoin on the morphology of gram-negative bacilli, J. Infect. Dis., 125, 187, 10.1093/infdis/125.2.187 Lorian, 1973, Electron microscopic study of the effect of ampicillin and cephalothin on Proteus mirabilis Lorian, 1975, Decrease in ribosomal density of Proteus mirabilis exposed to subinhibitory concentrations of ampicillin or cephalothin (38888), Proc. Soc. Exp. Biol. Med., 149, 731, 10.3181/00379727-149-38888 Lorian, 1985, Weight and morphology of bacteria exposed to antibiotics, 65 Majeski, 1977, Evaluation of tetracycline in the neutrophil chemotactic response, J. Lab. Clin. Med., 90, 259 Majeski, 1976, Effect of antibiotics on the in vitro neutrophil chemotactic response, Am. Surg., 42, 785 Mandell, 1973, Interaction of intraleukocytic bacteria and antibiotics, J. Clin. Invest., 52, 1673, 10.1172/JCI107348 Mandell, 1982, Effects of antimicrobial and antineoplastic drugs on the phagocytic and microbicidal function of the polymorphonuclear leukocyte, Rev. Infect. Dis., 4, 683, 10.1093/clinids/4.3.683 Mandell, 1982, Effects of antibiotic, antifungal and antiviral drugs on neutrophil function, Vol. I, 184 Mandell, 1985, Interactions between human polymorphonuclear neutrophils and ampicillins treated Escherichia coli Mandell, 1988, Interactions among subinhibitory (subMIC) antibiotics, aerobic gram-negative rods and human polymorphonuclear neutrophils (PMNs) Martin, 1980, Serial studies of leukocyte chemiluminescence: Lack of effect of macrolide antibiotic therapy, J. Med., 11, 39 Martin, 1973, Chemotaxis of human leukocytes: Responsiveness of Mycoplasma pneumoniae, J. Lab. Clin. Med., 81, 520 Martin, 1974, Effects of tetracycline on leukotaxis, J. Infect. Dis., 129, 110, 10.1093/infdis/129.2.110 Matheson, 1982, Trimethoprim induced augmentation of human natural killer activity in vitro, Immunopharmacol., 4, 73, 10.1016/0162-3109(82)90027-3 McCurrach, 1970, The effect of some drugs which induce agranulocytosis on the metabolism of separated human polymorphonuclear leukocytes and lymphocytes, Br. J. Pharmacol., 38, 608, 10.1111/j.1476-5381.1970.tb10602.x Melby, 1977, The effect of eight antibacterial agents on the phagocytosis of P-labeled Escherichia coli by rat polymorphonuclear cells, Scand. J. Infect. Dis., 9, 9, 10.3109/inf.1977.9.issue-1.03 Milatovic, 1982, Effect of subinhibitory antibiotic concentrations on the phagocytosis of Staphylococcus aureus, Eur. J. Clin. Microbiol., 1, 97, 10.1007/BF02014199 Milatovic, 1987, Subinhibitory concentrations of antibiotics and the function of granulocytes, Hyg. u. Med., 12, 46 Miller, 1973, Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells. I, J. Nat. Cancer Inst., 51, 1669, 10.1093/jnci/51.5.1669 Mizel, 1978, Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P338D1. I. Enhancement of LAF production by activated T lymphocytes, J. Immunol., 120, 1497 Mizel, 1978, Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P338D1, Cell. Immunol., 40, 230, 10.1016/0008-8749(78)90330-1 Mukerjee, 1973, Effect of rifampin on cutaneous hypersensitivity to purified protein derivative in humans, Antimicrob. Agents Chemother., 4, 607, 10.1128/AAC.4.6.607 Munoz, 1950, Inhibition of phagocytosis by aureomycin, Proc. Soc. Exp. Biol. Med., 75, 367, 10.3181/00379727-75-18201 Munster, 1977, The effect of antibiotics on cell-mediated immunity, Surgery, 81, 692 Naess, 1987, Effects of clindamycin on leukocyte membrane receptors and function, Scand. J. Immunol., 26, 322 Nagayama, 1986, Enhanced killing of cefodizime (HR221) treated Escherichia coli by macrophages and leukocytes, 26 Neter, 1969, Endotoxins and the immune response, Curr. Top. Microbiol. Immunol., 47, 92 Nilsson, 1971, Rifampicin: An immunosuppressant? (letter), Lancet, 2, 374, 10.1016/S0140-6736(71)90087-0 Nishida, 1976, Effect of antibiotics on the phagocytosis and killing of Pseudomonas aeruginosa by rabbit polymorphonuclear leukocytes, Chemotherapy, 22, 203, 10.1159/000221927 Nixdorff, 1985, Change in outer membrane composition after treatment of Proteus mirabilis with antibiotics, 57 Ofek, 1979, Suppression of bacterial adherence by subminimal inhibitory concentrations of β-lactam and aminoglycoside antibiotics, Rev. Infect. Dis., 1, 832, 10.1093/clinids/1.5.832 Ogawa, 1986, Effects of various antibiotics on antibody-producing cells of mouse spleen, Chemotherapy, 32, 464, 10.1159/000238452 Opferkuch, 1985, The effect of sublethal concentrations of antibiotics on the host-parasite-relationship, 165 Opferkuch, 1987, The influence of subinhibitory concentrations of antibiotics on the bacterial surface with respect to host defense mechanisms, 15 Ortiz-Ortiz, 1970, Enhancement by the adjuvant endotoxin of an immune response induced in vitro, Immunology, 19, 387 Page, 1978, Effects of prostaglandin on the antigen- and mitogen-driven responses of peripheral blood lymphocytes from patients with adult and juvenile periodontitis, Clin. Immunol. Immunopath., 11, 77, 10.1016/0090-1229(78)90205-2 Patselas, 1988, Effect of trimethoprim/sulfomethoxazole (TMP/SMX) on human neutrophil function and survival of mice infected with Candida albicans Pawelzik, 1985, The effect of antibiotics on the killing of E. coli by macrophages of the cell line P388D1, 131 Perkins, 1973, Scanning electron microscopy of morphological alterations in Proteus mirabilis induced by cephalosporins and semisynthetic penicillins, Can. J. Microbiol., 19, 251, 10.1139/m73-038 Persson, 1977, Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen, J. Immunol., 118, 789 Pisciotta, 1967, Inhibition of mitosis by chloramphenicol in phytohemagglutinin stimulated lymphocytes, Blood, 30, 457, 10.1182/blood.V30.4.457.457 Pocidalo, 1987, Antibiotics and suppression of lymphocyte response in vitro: Protection by thiol compounds, 243 Pruul, 1979, Enhancement of leukocyte activity against Escherichia coli after brief exposure to chloramphenicol, Antimicrob. Agents Chemother., 16, 695, 10.1128/AAC.16.6.695 Pruul, 1972, Interaction of complement and polymyxin with gram-negative bacteria, Infect. Imm., 6, 709, 10.1128/IAI.6.5.709-717.1972 Pruul, 1980, Activity of human leukocyte granule extract on antibiotic-damaged bacteria Pusztai-Markos, 1988, In vitro effect of different antimicrobial agents on the Il-2 production and Il-2 receptor expression of human lymphocytes Ramirez-Ronda, 1980, Effects of teichoic acids on adherence of S. sanguis, S. mutants and enterococci to damaged heart valves in vitro, Clin. Res., 28, 377A Reinberg, 1983, Introduction to chronobiology, 1 Reinberg, 1983, Investigative methodology for chronobiology, 23 Renoux, 1972, Effets de Poxytétracycline sur la formation d’anticorps et sur l’hypersensibilité retardée, Ann. Inst. Pasteur, 122, 205 Roche, 1988, Enhancement of interleukin-2 prodution by quinolone-treated human mononuclear leukocytes, Int. J. Immunopharmac., 10, 161, 10.1016/0192-0561(88)90091-4 Röllinghoff, 1983, Interleukine: Ihre Rolle und Wirkung bei der immunologischen Abwehrreaktion, Allergologie, 6, 397 Röllinghoff, 1983, Interleukine: Signalstoffe des Immunsystems, Die gelben Hefte, XXIII, 129 Root, 1981, Interactions between antibiotics and human neutrophils in the killing of staphylococci, J. Clin. Invest., 67, 247, 10.1172/JCI110020 Roselle, 1980, Amphotericin B and 5-fluorocytosine: Effects on cell-mediated immunity, Clin. Exp. Immunol., 40, 186 Roszkowski, 1985, The effect of subinhibitory concentrations of selected antibiotics on bacteria-phagocyte interaction, 179 Roszkowski, 1985, Effect of selected antibiotics on the cullular and humoral immune response in mice, 59 Rowan-Kelly, 1984, Modification of polymorphonuclear leukocyte function by imidazoles, Intern. J. Immunopharmac., 6, 389, 10.1016/0192-0561(84)90059-6 Ruben, 1974, Immunological responsiveness of tuberculosis patients receiving rifampicin, Antimicrob. Agents Chemother., 5, 383, 10.1128/AAC.5.4.383 Rubenstein, 1973, False-negative N. B. T. tests due to transient malfunctions of neutrophils, Lancet, 1, 382, 10.1016/S0140-6736(73)90185-2 Sanders, 1979, Emergence of resistance of cefamandole: Possible role of cefoxitin-inducible ß-lactamases, Antimicrob. Agents Chemother., 15, 792, 10.1128/AAC.15.6.792 Schroten, 1987, Influence of antibiotics on phagocytosis of Klebsiella pneumoniae by guinea pig alveolar macrophages, 211 Seklecki, 1978, Aminoglycoside antibiotics moderately impair granulocyte function, Antimicrob. Agents Chemother., 13, 552, 10.1128/AAC.13.3.552 Seneca, 1966, Effect of antibacterials, antibiotics, enzymes and steroids on phagocytosis, J. Am. Geriatr. Soc., 14, 187, 10.1111/j.1532-5415.1966.tb05308.x Serrou, 1974, Rifampicin and immunosuppression (letter), Lancet, 2, 172, 10.1016/S0140-6736(74)91611-0 Shibl, 1977, The effect of antibiotics on enzyme and toxin production by Staphylococcus aureus Shirley, 1979, Immunopotentiating effects of amphotericin B. I. Enhanced contact sensitivity in mice, J. Immunol., 123, 2878, 10.4049/jimmunol.123.6.2878 Siegmund-Schultze, 1985, Effects of antibiotics on the sensitivity of Proteus mirabilis to the bactericidal action of normal human serum, 107 Siegmund-Schultze, 1987, Antibiotic susceptibility of bacteria as related to immunogenicity, 63 Smith, 1980, T cell growth factor, Immunol. Rev., 51, 337, 10.1111/j.1600-065X.1980.tb00327.x Solbach, 1983, Die Rolle von Interleukin-2 bei der Aktivierung von zytotoxischen T-Lymphozyten, Klin. Wschr., 61, 67, 10.1007/BF01496657 Strominger, 1969, Competitive inhibition of enzymatic reactions by oxamycin, J. Am. Chem. Soc., 82, 998, 10.1021/ja01489a058 Stapley, 1969, Phosphomycin I discovery and in vitro biological characterization, Antimicrob. Agents Chemother., 1968, 284 Stephens, 1985, Effect of subinhibitory concentrations of antibiotics on surface proteins of Neisseria meningitidis: Changes that alter attachement of human cells, 3 Stobo, 1982, Cellular interactions in the expression and regulation of immunity, 89 Spath, 1971, Studies on the immune response to penicillin and cephalothin in humans. II Immunohematologic reactions to cephalothin administration, J. Immunol., 107, 860, 10.4049/jimmunol.107.3.860 Sud, 1975, Detection of agents that alter the bacterial cell surface, Antimicrob. Agents Chemother., 8, 34, 10.1128/AAC.8.1.34 Svanborg Eden, 1978, Decrease in adhesion of E. coli to human urinary tract epithelial cells in vitro by subinhibitory concentrations of ampicillin, Infection, 6, 121, 10.1007/BF01646082 Taylor, 1981, Effect of subinhibitory concentrations of mecillinam on the serum susceptibility of Escherichia coli strains, Antimicrob. Agents Chemother., 19, 786, 10.1128/AAC.19.5.786 The, 1974, Biphasic effect of cyclic AMP on immune response, Nature, 250, 505, 10.1038/250505a0 Thong, 1979, Inhibition of mitogen-induced lymphocyte proliferative responses by tetracycline analogous, Clin. Exp. Immunol., 35, 443 Toremalm, 1982, Local effect of penicillin drugs on the mucociliary activity in vitro, Vol. I, 189 Traub, 1970, Studies on the interaction between serum bactericidal activity and antibiotics in vitro, Chemotherapy, 15, 70, 10.1159/000220669 Tulasne, 1948, Cytology of staphylococci before and after treatment with penicillin, Nature, 161, 223, 10.1038/161316b0 Uchigama, 1978, Modulation of immune response by bacterial lipopolysaccharide (LPS): Multifocal effects of LPS-induced suppression of the primary antibody response to a T dependent antigen, J. Immunol., 121, 2340, 10.4049/jimmunol.121.6.2340 Van der Auwera, 1988, Interaction between the DNA-gyrase inhibitor coumermycin (C) Verhoef, 1988, Influence of antibiotics on uptake of bacteria by PMN Verhoef, 1985, Influence of antibiotics on opsonization of staphylococci, 115 Veringa, 1985, Influence of subinhibitory concentrations of clindamycin on the phagocytosis of Staphylococcus aureus, 125 Veringa, 1987, Influence of subinhibitory concentrations of clindamycin on phagocytosis of S. aureus, 159 Viano, 1979, Variability of immune response induced by bacteria treated with subminimal inhibitory concentrations of fosfomycin, Rev. Infect. Dis., 1, 858, 10.1093/clinids/1.5.858 Wagner, 1980, T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (interleukin-2) as a probe to anaylse CTL progenitors, Immunol. Rev., 51, 215, 10.1111/j.1600-065X.1980.tb00323.x Wagner, 1978, T-T cell interactions during in vitro cytotoxic allograft responses: I soluble products from activated Ly 1+ T cells trigger autonomously antigen primed Ly 23+ T cells to cell proliferation and cytolytic activity, J. Exp. Med., 148, 1523, 10.1084/jem.148.6.1523 Waisbren, 1964, Effect of wide-spectrum antibiotics on bactericidal activity of human serum: In vitro and in vivo, Am. J. Med. Sci., 248, 56, 10.1097/00000441-196407000-00009 Warnock, 1988, Effects of amphotericin B and methotrexate alone and in combination on the function of human neutrophils Wasik, 1981, The effect of ampicillin on antibody dependent (ADCC) and lectin induced (LICC) cellular cytotoxicity, Arch. Immunol. Therap. Exp., 29, 373 Wecke, 1988, Reduced cell wall degradation of staphylococci after pretreatment with clindamycin or erythromycin Weisberger, 1964, Suppression of antibody synthesis and prolongation of homograft survival by chloramphenicol, J. Exp. Med., 120, 183, 10.1084/jem.120.2.183 Welch, 1981, Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function, Antimicrob. Agents Chemother., 20, 15, 10.1128/AAC.20.1.15 Wiemer, 1985, Imipenem renders serum resistant Enterobacter aerogenes and Escherichia coli to serum sensitive bacteria, 117 Wiemer, 1987, The influence of antibiotics on the serum resistance of Enterobacteriaceae, 101 Wilkinson, 1978, Assay systems for measuring leukocyte locomotion: An overview, 1 Wittke, 1987, Influence of antibiotics on mitogen-stimulated and non-stimulated murine splenic lymphocytes, 231 Yokota, 1986, Synergy of antibacterial activity between cefodizime (THR-221) and the serum complement, and mouse polymorphonuclear leukocytes (PMNs) and/or macrophages (MØ), 29 Yunis, 1973, Chloramphenicol-induced bone marrow suppression, Semin. Hematol., 10, 225 Zimmermann, 1976, Relative morphological effects induced by cefoxitin and other β-lactam antibiotics in vitro, Antimicrob. Agents Chemother., 9, 318, 10.1128/AAC.9.2.318