Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022

Eurosurveillance - Tập 27 Số 19 - 2022
Ruben H. de Kleine1,2, Willem S. Lexmond3,2, Gustav Buescher4,2, Ekkehard Sturm2,5, D A Kelly2,6, Ansgar W. Lohse4,2, Dominic Lenz7,2, Marianne Hørby Jørgensen8,2
1Department of Surgery, Division of Hepatobiliairy Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
2European Reference Network for hepatological diseases (ERN RARE-LIVER)
3Department of Paediatrics, Division of Gastroenterology and Hepatology, Beatrix Children's Hospital, University of Groningen, Groningen, The Netherlands
4Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
5Paediatric Gastroenterology/ Hepatology, University Hospital Tuebingen, Tuebingen, Germany
6University of Birmingham, and The Liver Unit, Birmingham Women & Children's Hospital, Birmingham, UK
7Division of Neuropaediatrics and Paediatric Metabolic Medicine, Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany
8Department of Paediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark

Tóm tắt

To detect potential concern about severe acute hepatitis in children, we conducted a survey among 50 ERN RARE-LIVER centres. By 26 April 2022, 34 centres, including 25 transplant centres, reported an estimated median of 3–5, 0–2 and 3–5 cases in 2021, 2020 and 2019 and a mean of 2 (range: 0–8) cases between January and April 2022 (mean in 10 large liver transplant centres: 3). Twelve centres reported suspicion of an increase, but no rise.

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Tài liệu tham khảo

World Health Organization (WHO). Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland. Geneva: WHO; 15 Apr 2022. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/acute-hepatitis-of-unknown-aetiology---the-united-kingdom-of-great-britain-and-northern-ireland

European Centre for Disease Prevention and Control (ECDC). Increase in severe acute hepatitis cases of unknown aetiology in children. Stockholm: ECDC; 28 Apr 2022. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/RRA-20220420-218.pdf

World Health Organization (WHO). Multi-Country – Acute, severe hepatitis of unknown origin in children. Geneva: WHO; 23 Apr 2022. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON376

Christie, 2022, Scientists search for cause of hepatitis cases in children., BMJ, 377, o982, 10.1136/bmj.o982

United Kingdom Health Security Agency (UKHSA). Increase in acute hepatitis cases of unknown aetiology in children. London: UKHSA; 8 Apr 2022. Available from: https://www.gov.uk/government/publications/hepatitis-increase-in-acute-cases-of-unknown-aetiology-in-children/increase-in-acute-hepatitis-cases-of-unknown-aetiology-in-children

Squire s RH Jr, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148(5):652-8. . PMID: 16737880

European Reference Network (ERN). Hepatological Diseases (ERN RARE-LIVER). What is ERN RARE-LIVER? [Accessed: 10 May 2022]. Available from: https://rare-liver.eu/about/what-is-ern-rare-liver

Squires, 2006, Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group., J Pediatr, 148, 652, 10.1016/j.jpeds.2005.12.051

Vandenbroucke, 2007, Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration., PLoS Med, 4, 10.1371/journal.pmed.0040297

Williams, 1923, Epidemic jaundice in New York State, 1921-1922., JAMA, 80, 532, 10.1001/jama.1923.02640350014007

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Eurosurveillance

Tập 27 Số 19

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