Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes

Clinical Endocrinology - Tập 69 Số 1 - Trang 74-80 - 2008
Haruhiko Osawa1, Masayuki Ochi2, Yasuharu Tabara3, Kenichi Kato4, Junko Yamauchi2, Yasunori Takata2, Wataru Nishida2, Hiroshi Onuma2, Ikki Shimizu4, Yasuhisa Fujii4, Tetsuro Miki5, Jun Ohashi6, Hideichi Makino2
1Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Prefectural Hospital, Ehime, Japan.
2Department of Molecular and Genetic Medicine,
3Department of Basic Medical Research and Education,
4Department of Internal Medicine, Ehime Prefectural Hospital, Ehime, Japan,
5Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
6Department of Human Genetics, School of International Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

Tóm tắt

SummaryObjective  Resistin, secreted from adipocytes, causes insulin resistance in rodents. We reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at −420 increases type 2 diabetes (T2DM) susceptibility by enhancing promoter activity. We also showed that serum resistin was positively correlated with G at SNP‐420, the duration of T2DM, and HbA1c in T2DM. The aim of this study was to determine the relation between serum resistin and factors related to the metabolic syndrome (MetS) in T2DM.Design, patients and measurements  We analysed 238 Japanese T2DM subjects (124 males and 114 females, age 60·2 ± 11·3 years, body mass index (BMI) 24·1 ± 3·9) whose overnight fasting sera were available. Serum resistin was measured using ELISA.Results  Serum resistin was higher in subjects with either obesity (P = 0·041), low HDL (P = 0·004), high triglycerides (TG) (P = 0·019), hypertension (HT) (P = 0·001) or atherosclerosis (P = 0·012). Simple regression analysis revealed that serum resistin was correlated with lower HDL, TG and high‐sensitivity C‐reactive protein (hsCRP). Multiple regression analysis (or logistic regression analysis for HT), adjusted for age, gender, BMI and the duration of T2DM, revealed that serum resistin was correlated with lower HDL (P = 0·008), TG (P = 0·041), HT (P = 0·031) and hsCRP (P = 0·004). Serum resistin was positively correlated with the number of MetS factors, independent of age, gender and the duration of T2DM (P < 0·001). Adjustment by either thiazolidinedione (TZD) treatment or hsCRP had no effects on these findings.Conclusions  Serum resistin was positively correlated with the accumulation of MetS factors in T2DM.

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Clinical Endocrinology

Tập 69 Số 1

74-80

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