Serum Concentrations of TNF α and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery

International Journal of Molecular Sciences - Tập 11 Số 6 - Trang 2281-2290
Jan Komorowski1, Jolanta Jurczyńska1, Tomasz Stępień2, Krzysztof Kołomecki2, Krzysztof Kuzdak2, H Stępień3
1Department of Clinical Endocrinology, First Chair of Endocrinology, Medical University of Lodz, Sterlinga1/3, 91-425 Lodz, Poland
2Department of Endocrine and General Surgery, First Chair of Endocrinology, Pabianicka 62, Medical University of Lodz, 93-513 Lodz, Poland
3Department of Immunoendocrinology, First Chair of Endocrinology, Medical University of Lodz, Sterlinga1/3, 91-425 Lodz, Poland

Tóm tắt

The peripheral blood levels of TNF α and its soluble receptors were studied in 39 patients with malignant and benign adrenal tumors treated by adrenalectomy. The concentrations of TNF α were significantly elevated in patients with malignant tumors of the adrenal cortex and in patients with Conn's syndrome compared to control. In patients with non-functioning adenomas and pheochromocytomas, TNF α levels were similar to those detected in the control. In subjects with myelolipomas, the serum concentration of TNF α was lower compared to the control. After adrenalectomy, the levels of TNF α were decreased in patients with malignant tumors and in patients with Conn's syndrome, non-functioniong adenomas and pheochromocytomas compared to the concentration before surgery. The serum concentrations of soluble receptors of TNF α did not differ among different patient groups and compared to the control. After adrenalectomy, the blood concentrations of TNF α R1 and TNF α R2 were decreased in patients with Conn's syndrome. However, to confirm practicality of the evaluation of TNF α and its soluble receptors in differential diagnosis in patients with adrenal tumors, a larger study group is needed.

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Tài liệu tham khảo

Zieleniewski, 2006, Angiogenic and anti-angiogenic factors in adrenal tumours, Endokrynol. Pol, 57, 633

Kuzdak, 2009, Peripheral blood concentrations of vascular endothelial growth factor and its soluble receptor (R1 and R2) in patients with adrenal cortex tumors treated by surgery, Endokrynol. Pol, 60, 9

Hiemar, 1994, Tumor necrosis factor for the treatment of malignancies, Oncology, 51, 142, 10.1159/000227329

Dembic, 1990, Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences, Cytokine, 2, 231, 10.1016/1043-4666(90)90022-L

Smith, 1990, A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins, Science, 248, 1019, 10.1126/science.2160731

Aderka, 1992, Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors, J. Exp. Med, 175, 323, 10.1084/jem.175.2.323

Chouaib, 1991, More insights into the complex physiology of TNF, Immunol. Today, 12, 141, 10.1016/S0167-5699(05)80041-6

Corti, 1998, Tumour necrosis factor: Strategies for improving the therapeutic index, J. Drug. Target, 5, 403, 10.3109/10611869808997869

Kwon, 1999, Functions of newly identified members of the tumor necrosis factor receptor/ligand superfamilies in lymphocytes, Curr. Opin. Immunol, 11, 340, 10.1016/S0952-7915(99)80054-5

Sedgwick, 2000, Tumor necrosis factor: A masterregulator of leukocyte movement, Immunol. Today, 21, 110, 10.1016/S0167-5699(99)01573-X

MacEwan, 2002, A TNF ligands and receptors-a matter of life and death, Br. J. Pharmacol, 135, 855, 10.1038/sj.bjp.0704549

MacEwan, 2002, B TNF receptor subtype signaling: Differences and cellular consequences, Cell Signal, 14, 477, 10.1016/S0898-6568(01)00262-5

Wellmer, 2001, Effect of deficiency of tumor necrosis factor α or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis, Infect. Immun, 69, 6881, 10.1128/IAI.69.11.6881-6886.2001

Pasparakis, 1996, A Immune and inflammatory responses in TNF α -deficient mice: A critical requirement for TNF α in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response, J. Exp. Med, 184, 1397, 10.1084/jem.184.4.1397

Mocellin, 2008, TNF and cancer: The two sides of the coin, Front. Biosci, 13, 2774, 10.2741/2884

Leibovich, 1987, Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α, Nature, 329, 630, 10.1038/329630a0

Schweigerer, 1987, Tumor necrosis factor inhibits the proliferation of cultured capillar endothelial cells, Biochem. Biophys. Res. Commun, 143, 997, 10.1016/0006-291X(87)90350-0

Call, 2000, Bovine adrenal cells secrete interleukin-6 and tumor necrosis factor in vitro, Gen. Comp. Endocrinol, 118, 249, 10.1006/gcen.2000.7458

Bornstein, 1994, Interleukin-6 messenger ribonucleic acid expression in human adrenal gland in vivo: New clue to a paracrine or autocrine regulation of adrenal function, J. Clin. Endocrinol. Metab, 79, 1492

Scherbaum, 1996, Human adrenal cells express tumor necrosis factor- α messenger ribonucleic acid: Evidence for paracrine control of adrenal function, J. Clin. Endocrinol. Metab, 81, 807

Bornstein, 1996, Direct effects of interleukin-6 on human adrenal cells, Endocr. Res, 22, 867, 10.1080/07435809609043788

Wilder, 1995, Neuroendocrine-immune system interactions and autoimmunity, Annu. Rev. Immunol, 13, 307, 10.1146/annurev.iy.13.040195.001515

Cimino, 1991, Serum interleukin-2 (IL-2), soluble IL-2 receptors and tumor necrosis factor-α levels are significantly increased in acute myeloid leukemia patients, Leukemia, 5, 32

Yurkovetsky, 2007, Multiplex analysis of serum cytokines in melanoma patients treated interferon- α 2b, Clin. Cancer Res, 13, 2422, 10.1158/1078-0432.CCR-06-1805

Dosquet, 1997, Are angiogenic factors, cytokines and soluble adhesion molecules prognostic factors in patients with renal cell carcinoma?, Clin. Cancer Res, 3, 2451

Smolarz, 2009, Tumor necrosis factor α and interferon γ genes polymorphisms and serum levels in pancreatic adenocarcinoma, Neoplasma, 56, 56, 10.4149/neo_2009_01_56

Fresno, 2008, IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages, J. Immunol, 181, 4461, 10.4049/jimmunol.181.7.4461

Creyghton, 1995, Cytokine-mediated modulation of integrin, ICAM-1 and CD44 expression on human uveal melanoma cells in vitro, Melanoma Res, 5, 235, 10.1097/00008390-199508000-00005

Haendeler, 2008, Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration, Biochem. Biophys. Res. Commun, 376, 748, 10.1016/j.bbrc.2008.09.070

Austgulen, 1992, Soluble TNF receptors in amniotic fluid and in urine from pregnant women, J. Reprod. Immunol, 22, 105, 10.1016/0165-0378(92)90009-S

Austgulen, 1992, Secretion of soluble receptors for tumor necrosis factor. An immunologic buffer mechanism during normal pregnancy?, Tidsskr. Nor. Laegeforen, 112, 3545

Kalinkovich, 1992, Elevated serum levels of soluble tumour necrosis factor receptors (sTNF-R) in patients with HIV infection, Clin. Exp. Immunol, 89, 351, 10.1111/j.1365-2249.1992.tb06961.x

Andus, 1992, High concentrations of soluble tumor necrosis factor receptors in ascites, Hepatology, 16, 749, 10.1002/hep.1840160322

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International Journal of Molecular Sciences

Tập 11 Số 6

2281-2290

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