Benoît Daubail1,2, Agnès Jacquin1,2, Jean-Claude Guilland3, Marie Hervieu1,2, Guy‐Victor Osseby1,2, Olivier Rouaud1,2, Maurice Giroud1,2, Yannick Béjot1,2
1France
2Department of Neurology and Dijon Stroke Registry EA4184 University Hospital and Medical School of Dijon University of Burgundy Dijon; France
3Biochimie Spécialisée Pôle Technique de Biologie Dijon University Hospital Dijon France
Tóm tắt
Background and purposeWe aimed to evaluate the association between 25‐hydroxyvitamin D (25(OH)D) levels and both clinical severity at admission and outcome at discharge in stroke patients.MethodsFrom February 2010 to December 2010, consecutive stroke patients admitted to the Department of Neurology of Dijon, France, were identified. Clinical information was collected. Serum concentration of 25(OH)D was measured at baseline. Stroke severity was assessed at admission using the NIHSS score. Functional impairment was evaluated at discharge using the modified Rankin scale (m‐Rankin). Multivariate analyses were performed using logistic regression models.ResultsOf the 386 recorded patients, serum 25(OH)D levels were obtained in 382 (median value = 35.1 nM; IQR = 21–57.8). At admission, 208 patients had a NIHSS ≤5, with a higher mean 25(OH)D level than that observed in patients with moderate‐to‐high severity (45.9 vs. 38.6 nM, P < 0.001). In multivariate analyses, a 25(OH)D level in the lowest tertile (<25.7 nM) was a predictor of a NIHSS ≥6 (OR = 1.67; 95% CI = 1.05–2.68; P = 0.03). The mean 25(OH)D level was lower in patients with moderate‐to‐severe handicap at discharge (m‐Rankin 3–6) than in patients with no or mild handicap (35.0 vs. 47.5 nM, P < 0.001). In multivariate analyses, the lowest tertile of 25(OH)D level (<25.7 nM) was associated with a higher risk of moderate‐to‐severe handicap (OR = 2.06; 95% CI = 1.06–3.94; P = 0.03).ConclusionA low serum 25(OH)D level is a predictor of both severity at admission and poor early functional outcome in stroke patients. The underlying mechanisms of these associations remain to be investigated.
