Sensation‐to‐cognition cortical streams in attention‐deficit/hyperactivity disorder

Human Brain Mapping - Tập 36 Số 7 - Trang 2544-2557 - 2015
Susanna Carmona1,2,3, Elseline Hoekzema4, F. Xavier Castellanos5,6, David García‐García1,3, Agustín Lage‐Castellanos7, Koene R. A. Van Dijk8,9, Francisco J. Navas‐Sánchez10,1, Kenia Martínez3, Manuel Desco10,1,3, Jorge Sepulcre8,11
1Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain
2Department of Psychology Harvard University, Center for Brain Science Cambridge Massachusetts
3Unidad de Medicina y Cirugía Experimental, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
4Neuroendocrinology Bakker Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
5Center for Neurodevelopmental Disorders, The Child Study Center at NYU Langone Medical Center New York New York
6Division of Child and Adolescent Psychiatric Research Nathan Kline Institute for Psychiatric Research Orangeburg New York
7Department of Neurostatistics, Cuba Neuroscience Center, Habana, Cuba.
8Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Charlestown Massachusetts
9Department of RadiologyAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical SchoolCharlestown Massachusetts
10Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain
11Division of Nuclear Medicine and Molecular Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts

Tóm tắt

AbstractWe sought to determine whether functional connectivity streams that link sensory, attentional, and higher‐order cognitive circuits are atypical in attention‐deficit/hyperactivity disorder (ADHD). We applied a graph‐theory method to the resting‐state functional magnetic resonance imaging data of 120 children with ADHD and 120 age‐matched typically developing children (TDC). Starting in unimodal primary cortex—visual, auditory, and somatosensory—we used stepwise functional connectivity to calculate functional connectivity paths at discrete numbers of relay stations (or link‐step distances). First, we characterized the functional connectivity streams that link sensory, attentional, and higher‐order cognitive circuits in TDC and found that systems do not reach the level of integration achieved by adults. Second, we searched for stepwise functional connectivity differences between children with ADHD and TDC. We found that, at the initial steps of sensory functional connectivity streams, patients display significant enhancements of connectivity degree within neighboring areas of primary cortex, while connectivity to attention‐regulatory areas is reduced. Third, at subsequent link‐step distances from primary sensory cortex, children with ADHD show decreased connectivity to executive processing areas and increased degree of connections to default mode regions. Fourth, in examining medication histories in children with ADHD, we found that children medicated with psychostimulants present functional connectivity streams with higher degree of connectivity to regions subserving attentional and executive processes compared to medication‐naïve children. We conclude that predominance of local sensory processing and lesser influx of information to attentional and executive regions may reduce the ability to organize and control the balance between external and internal sources of information in ADHD. Hum Brain Mapp 36:2544–2557, 2015. © 2015 Wiley Periodicals, Inc.

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Human Brain Mapping

Tập 36 Số 7

2544-2557

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