Selenium level is associated withapoE ε4in rural elderly Chinese

Public Health Nutrition - Tập 12 Số 12 - Trang 2371-2376 - 2009
Sujuan Gao1, Yinlong Jin2, Kathleen Hall3, Chaoke Liang2, Frederick W. Unverzagt3, Feng Ma2, Yibin Cheng2, Jianzhao Shen1, Jingxiang Cao2, Janetta Matesan1, Ping Li4, Jianchao Bian5, Hugh C. Hendrie3,6,7, Jill R. Murrell8
1Department of Medicine, Indiana University School of Medicine, 410 West 10th Street – Suite 3000, Indianapolis, IN 46202-2872, USA
2Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
3Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
4Sichuan Provincial Center for Disease Control and Prevention in China, Chengdu, People’s Republic of China
5Shandong Institute for Prevention and Treatment of Endemic Disease in China, Jinan, People’s Republic of China
6Indiana University Center for Aging Research, Indianapolis, IN, USA
7Regenstrief Institute, Inc., Indianapolis, IN, USA
8Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

Tóm tắt

AbstractObjective

Se is an essential trace element in human nutrition associated with antioxidant activity. Previous studies on predictors of toenail Se or serum Se have mostly concentrated on demographic factors such as age and gender. The present paper examines the association betweenapoEgenotype and Se levels in nail samples in a rural elderly Chinese cohort.

Design

Two thousand Chinese aged 65 years and over from four counties in China were enrolled in a cohort to study the association of Se with cognitive decline. Nail samples were collected from each participant and analysed for Se levels. Dietary Se intake was estimated from an FFQ using Se contents measured in food items collected from each village. Blood samples on filter cards were collected and analysed forapoEgenotype. Mixed-effect models were constructed with nail Se level as the dependent variable and each village as the random effect, which controlled for the potential confounding effect from correlation in Se measures obtained from participants residing in the same village.

Results

In this elderly Chinese cohort, carriers of theapoE ε4allele had significantly lower Se levels measured in nail samples than non-carriers after adjusting for other significant covariates and controlling for estimated dietary Se intake. There was no significant difference between the two genotypes on estimated Se dietary intake (P= 0·6451).

Conclusions

Future studies are needed to examine the mechanism underlying the association between theapoE ε4allele and Se levels, including the role of oxidative stress and that of reduced lipid metabolism in theapoE ε4carriers.

Từ khóa


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Public Health Nutrition

Tập 12 Số 12

2371-2376

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