Selective effects of ECT on hypothalamic—pituitary activity

Psychological Medicine - Tập 17 Số 2 - Trang 319-328 - 1987
Lawrence J. Whalley1, John Eagles1, Geoffrey M. R. Bowler1, J. Bennie1, H. Dick1, Ralph McGuire1, George Fink1
1MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh

Tóm tắt

SynopsisThe hypothesis that ECT produces selective effects on hypothalamic–pituitary activity was investigated by determining the effect of ECT on pituitary hormone release in nine depressed patients. After ECT there were massive and rapid increases in the plasma concentrations of nicotine-and oestrogen-stimulated neurophysin (NSN and ESN), prolactin (PRL) and adrenocorticotropin (ACTH), smaller increases in plasma luteinizing hormone (LH) and cortisol, a significant decrease in plasma growth hormone (GH) concentration but no change in plasma thyrotropin (TSH). There was significant attenuation of PRL responses with repeated ECT. The hormonal responses to ECT cannot simply be attributed to stress, since a similar pattern of increases in plasma hormone concentrations did not occur in psychologically normal patients in whom plasma hormone concentrations were measured during induction of anaesthesia and abdominal incision for cholecystectomy. Analysis of these hormonal responses in terms of the knowledge available on the neurotransmitter control of pituitary hormone release suggests that some of these hormonal responses to ECT may be mediated by the activation of serotonergic neurones, while others are probadly due to direct stimulation of the neuroendocrine neurones themselves.

Từ khóa


Tài liệu tham khảo

10.1038/268544a0

10.1111/j.1600-0447.1984.tb01221.x

10.1016/0306-4522(83)90219-1

10.1001/archpsyc.1983.04390010087011

10.1001/archpsyc.1981.01780350094011

10.1016/S0140-6736(86)91557-6

Winer, 1971, Statistical Principles in Experimental Design, 514

10.1016/S0140-6736(82)90004-6

10.1038/257495a0

10.1016/S0140-6736(82)90115-5

10.1192/bjp.144.6.643

10.1210/endo-113-3-939

10.1016/S0140-6736(79)90562-2

10.1210/jcem-59-3-526

10.3181/00379727-157-40080

10.1113/jphysiol.1979.sp012780

Fink, 1978, International Review of Physiology, Neurophysiology III, 17, 1

10.1146/annurev.ph.45.030183.000545

10.1007/BF00427287

Fink, 1986, The endocrine control of ovulation, Science Progress, 70, 403

10.1159/000122766

10.1152/physrev.1983.63.4.1243

O'Dea, 1978, Prolactin changes during electro-convulsive therapy, American Journal of Psychiatry, 135, 609, 10.1176/ajp.135.5.609

10.1016/S0140-6736(69)91140-4

10.1210/endo-113-1-318

10.1016/0024-3205(78)90227-8

10.1038/285232a0

10.1038/282746a0

10.1016/S0140-6736(78)92571-0

10.1016/S0140-6736(78)90495-6

10.1159/000122013

Tuomisto, 1985, Neurotransmitter regulation of anterior pituitary hormones, Pharmacological Reviews, 37, 249

10.1001/archpsyc.1983.01790020079007

10.1677/joe.0.1060275

Abel, 1974, Changes in plasma corticosterone and hypothalamic CRF levels following intraventricular injection or drug-induced changes of brain biogenic amines in the rat, Neuroendocrinology, 14, 198

Delitalia, 1977, Effects of electroconvulsive therapy (electro shock) on plasma ACTH, GH, LH, FSH, TSH and 11-OH CS in variance with mental disorders, Panminerva Medica (Torino), 19, 237

10.1016/0306-4530(82)90034-8

Cross, 1975, Endocrine neurons, Recent Progress in Hormone Research, 31, 243

10.1677/joe.0.0930151

10.1192/bjp.143.6.618

10.1016/S0140-6736(76)90895-3

10.1192/bjp.144.4.407

10.1136/jnnp.23.1.56

10.1159/000123965

Buckingham, 1980, Corticotrophin releasing factor, Pharmacological Reviews, 31, 253

10.1016/0006-2952(78)90226-5

Checkley, 1982, Neuropeprides Basic and Clinical Aspects, 167

10.1007/BF00426463

10.1111/j.1600-0447.1980.tb00873.x

10.1677/joe.0.1040211

10.1007/BF00237553

10.1210/endo-107-4-863

10.1159/000123224

10.1677/joe.0.1040415

Loosen, 1982, Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review, American Journal of Psychiatry, 139, 405, 10.1176/ajp.139.4.405

Mannisto, 1979, Dual action of adrenergic system on the regulation of thyrotrophin secretion in the male rat, Acta Endocrinology, 90, 249, 10.1530/acta.0.0900249

10.1159/000123539

10.1016/0024-3205(82)90686-5

10.1152/physrev.1978.58.4.905

Alllen, 1974, Corticotrophin release during ECT in man, American Journal of Psychiatry, 131, 1255

10.1210/edrv-3-1-91

Balldin, 1982, Factors influencing prolactin release induced by electro-convulsive therapy, Acta Psychiatrica Scandinavica, 65, 365, 10.1111/j.1600-0447.1982.tb00857.x

10.1677/joe.0.1040397

Lincoln, Oxytocin; Clinical and Laboratory Aspects, 53

Nakai, 1973, Adrenergic control mechanism for ACTH secretion in man, Acta Endocrinologica, 74, 263, 10.1530/acta.0.0740263

10.1210/endo-112-4-1217

10.1126/science.6267699

10.1038/299355a0

Thông tin
Thông tin xuất bản

Psychological Medicine

Tập 17 Số 2

319-328

Thông tin tác giả