Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Pharmaceutics - Tập 12 Số 2 - Trang 110
Nour Allahham1, Fabrizio Fina2, Carmen Marcuta3, Lilia Kraschew3, Wolfgang Mohr3, Simon Gaisford4, Abdul W. Basit4, Álvaro Goyanes5
1FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK
2Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29–39 Brunswick Square, London WC1N 1AX, UK
3Losan Pharma GmbH, Otto-Hahn-Strasse 13, 79395 Neuenburg, Germany
4Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29–39 Brunswick Square, London WC1N 1AX, UK; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK
5Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK

Tóm tắt

The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

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