Selected commercial plants: A review of extraction and isolation of bioactive compounds and their pharmacological market value

Trends in Food Science & Technology - Tập 82 - Trang 89-109 - 2018
Jayanta Kumar Patra1, Gitishree Das1, Siyoung Lee2, Seok-Seong Kang2, Han-Seung Shin2
1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyang-si 10326, Republic of Korea
2Department of Food Science and Biotechnology, Dongguk University-Seoul, Goyang-si 10326, Republic of Korea

Tài liệu tham khảo

healthBenefitscom, 2018, Vol. 2018 whfoodscom, 2018, Vol. 2018 Abbaszadeh, 2009, Studying of essential oil variations in leaves of Mentha species, African Journal of Plant Science, 3, 217 Abnewswire, 2016, Vol. 2018 Adam, 2009, Extraction of antioxidants from plants using ultrasonic methods and their antioxidant capacity, Journal of Separation Science, 32, 288, 10.1002/jssc.200800543 Aggarwal, 2007, Vol. 595 Agrawal, 2009 Agronews, 2017, Vol. 2018 Aguiar, 2013, Neuropharmacological review of the nootropic herb Bacopa monnieri, Rejuvenation Research, 16, 313, 10.1089/rej.2013.1431 Alzohairy, 2016, Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment, Evidence-based Complementary and Alternative Medicine, 2016, 10.1155/2016/7382506 Amalraj, 2017, Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives–A review, Journal of traditional and complementary medicine, 7, 205, 10.1016/j.jtcme.2016.05.005 Ammon, 1991, Pharmacology of curcuma longa, Planta Medica, 57, 1, 10.1055/s-2006-960004 Anonymous, 2004, Bacopa monnieri. Monograph, Altern. Med. Rev., 9, 79 Anubala, 2016, Determination of curcuminoids and their degradation products in turmeric (curcuma longa) rhizome herbal products by non-aqueous capillary electrophoresis with photodiode array detection, Food Analytical Methods, 9, 2567, 10.1007/s12161-016-0438-1 Arct, 2014, Evaluation of skin colouring properties of curcuma longa extract, Indian Journal of Pharmaceutical Sciences, 76, 374 Aremu, 2009, Physico-chemical stability studies of neem (Azadirachta indica) seed oil cream, African Research Review, 3, 10.4314/afrrev.v3i3.47509 Arora, 2013, Chapter 38 - cardioprotective efficacy of alternative and complementary therapeutics, 657 Arslan, 2010, Evaluation of drying methods with respect to drying parameters, some nutritional and colour characteristics of peppermint (Mentha x piperita L.), Energy Conversion and Management, 51, 2769, 10.1016/j.enconman.2010.06.013 Arumugam, 2008, Anti-inflammatory activity of four solvent fractions of ethanol extract of Mentha spicata L. investigated on acute and chronic inflammation induced rats, Environmental Toxicology and Pharmacology, 26, 92, 10.1016/j.etap.2008.02.008 Ashashri, 2015, Conservation and sustainability of ashwagandha: A medicinal plant, Journal of Biological and Scientific Opinion, 3 Asif, 2013, A review on spermicidal activities of Azadirachta indica, Journal of Pharmacognosy and Phytochemistry, 1 Attele, 1999, Ginseng pharmacology: Multiple constituents and multiple actions, Biochemical Pharmacology, 58, 1685, 10.1016/S0006-2952(99)00212-9 Aziz, 2018, Traditional uses of medicinal plants used by Indigenous communities for veterinary practices at Bajaur Agency, Pakistan, Journal of Ethnobiology and Ethnomedicine, 14, 11, 10.1186/s13002-018-0212-0 Azmir, 2013, Techniques for extraction of bioactive compounds from plant materials: A review, Journal of Food Engineering, 117, 426, 10.1016/j.jfoodeng.2013.01.014 Azwanida, 2015, A review on the extraction methods use in medicinal plants, principle, strength and limitation, Medicinal & Aromatic Plants, 4, 3 Baeg, 2013, The world ginseng market and the ginseng (Korea), Journal of ginseng research, 37, 1, 10.5142/jgr.2013.37.1 Bahadori, 2018, Phenolic composition and functional properties of wild mint (Mentha longifolia var. calliantha (Stapf) Briq.), International Journal of Food Properties, 21, 183, 10.1080/10942912.2018.1440238 Bakkali, 2008, Biological effects of essential oils–a review, Food and Chemical Toxicology, 46, 446, 10.1016/j.fct.2007.09.106 Bammidi, 2011, A review on pharmacological studies of Bacopa monniera, Journal of Chemical, Biological and Physical Sciences (JCBPS), 1, 250 Barfi, 2016, In-syringe reversed dispersive liquid–liquid microextraction for the evaluation of three important bioactive compounds of basil, tarragon and fennel in human plasma and urine samples, Journal of Pharmaceutical and Biomedical Analysis, 121, 123, 10.1016/j.jpba.2016.01.003 Begum, 2008, Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease, Journal of Pharmacology and Experimental Therapeutics, 326, 196, 10.1124/jpet.108.137455 Beigi, 2018, Quantity and chemical composition of essential oil of peppermint (Mentha× piperita L.) leaves under different drying methods, International Journal of Food Properties, 21, 267, 10.1080/10942912.2018.1453839 Belwal, 2018, A critical analysis of extraction techniques used for botanicals: Trends, priorities, industrial uses and optimization strategies, TRAC Trends in Analytical Chemistry, 100, 82, 10.1016/j.trac.2017.12.018 Bensky, 2004 Bhajoni, 2016, Evaluation of the antiulcer activity of the leaves of Azadirachta indica: An experimental study, Integrative Medicine International, 3, 10, 10.1159/000442750 Bharti, 2016, Ashwagandha: Multiple health benefits, 717 Bhasin, 2012, Ocimum-Taxonomy, medicinal potentialities and economic value of essential oil, Journal of Biosphere, 1, 48 Bhateja, 2012, Therapeutic benefits of holy basil (tulsi) in general and oral medicine: a review, International Journal of Research in Ayurveda and Pharmacy, 3, 4, 10.7897/2277-4343.03611 Biesalski, 2002, Nutraceuticals: The link between nutrition and medicine, Journal of Toxicology - Cutaneous and Ocular Toxicology, 21, 9, 10.1081/CUS-120004324 Bijalwan, 2017, Scaling-up of neem (Azadirachta indica A. Juss) cultivation in agroforestry for entrepreneurship and economic strengthening of rural community of India, International Journal of Current Research in Biosciences and Plant Biology, 4, 6, 10.20546/ijcrbp.2017.401.014 Biswas, 2002, Biological activities and medicinal properties of neem (Azadirachta indica), 1336 Braeckman, 1994, The extract of serenoa repens in the treatment of benign prostatic hyperplasia: A multicenter open study, Current Therapeutic Research, 55, 776, 10.1016/S0011-393X(05)80771-4 Brahmi, 2017, Chemical composition and biological activities of Mentha species Brierley, 2011, Use of natural products in gastrointestinal therapies, Current Opinion in Pharmacology, 11, 604, 10.1016/j.coph.2011.09.007 Brusotti, 2014, Isolation and characterization of bioactive compounds from plant resources: The role of analysis in the ethnopharmacological approach, Journal of Pharmaceutical and Biomedical Analysis, 87, 218, 10.1016/j.jpba.2013.03.007 Butterworth, 1972, The structure of azadirachtin; the functional groups, Journal of the Chemical Society, Perkin Transactions, 1, 2445, 10.1039/p19720002445 Cameron, 2005, Linking medicinal/nutraceutical products research with commercialization, Pharmaceutical Biology, 43, 425, 10.1080/13880200590963736 Cao, 2015, Analysis of major withanolides in Physalis longifolia Nutt. By HPLC-PDA, Journal of chromatographic science, 53, 1044, 10.1093/chromsci/bmu162 Chakravarty, 2003, Bacopasides III—V: Three new triterpenoid glycosides from Bacopa monniera, Chemical and Pharmaceutical Bulletin, 51, 215, 10.1248/cpb.51.215 Chandra, 2016, An industrial cultivation of Tulsi (Ocimum sanctum) for medicinal use and rural empowerment, Journal of Medicinal Plants, 4, 213 Chandrasekhar, 2012, A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults, Indian Journal of Psychological Medicine, 34, 255, 10.4103/0253-7176.106022 Chávez-González, 2016, Chapter 11 - essential oils: A natural alternative to combat antibiotics resistance, 227 ChEBI, 2018, CHEBI:69120 - withaferin A Chemler, 2008, Metabolic engineering for plant natural product biosynthesis in microbes, Current Opinion in Biotechnology, 19, 597, 10.1016/j.copbio.2008.10.011 Chenni, 2016, Comparative study of essential oils extracted from Egyptian basil leaves (Ocimum basilicum L.) Using hydro-distillation and solvent-free microwave extraction, Molecules, 21, 113, 10.3390/molecules21010113 Chibber, 2014, Medicinal and therapeutical potential of neem (Azadirachta indica): A review, International Journal of Scientific and Research Publications, 4, 1 Chikezie, 2015, Bioactive principles from medicinal plants, Research Journal of Phytochemistry, 9, 88, 10.3923/rjphyto.2015.88.115 Christensen, 2006, Simultaneous determination of ginsenosides and polyacetylenes in american ginseng root (Panax quinquefolium L.) by high-performance liquid chromatography, Journal of Agricultural and Food Chemistry, 54, 8995, 10.1021/jf062068p Ciobanu, 2013, Retention of aroma compounds from Mentha piperita essential oil by cyclodextrins and crosslinked cyclodextrin polymers, Food Chemistry, 138, 291, 10.1016/j.foodchem.2012.10.106 Cooley, 2009, Naturopathic care for anxiety: A randomized controlled trial ISRCTN78958974, PloS One, 4, e6628, 10.1371/journal.pone.0006628 Corbit, 2005, Simplified extraction of ginsenosides from american ginseng (Panax quinquefolius L.) for high-performance liquid Chromatography−Ultraviolet analysis, Journal of Agricultural and Food Chemistry, 53, 9867, 10.1021/jf051504p Cosmetics info, 2016, Panax ginseng root Cozzolino, 2016, Extraction and curcuminoids activity from the roots of Curcuma longa by RSLDE using the Naviglio extractor, European Scientific Journal, ESJ, 12 Da Porto, 2009, Ultrasound-assisted extraction coupled with under vacuum distillation of flavour compounds from spearmint (carvone-rich) plants: Comparison with conventional hydrodistillation, Ultrasonics Sonochemistry, 16, 795, 10.1016/j.ultsonch.2009.03.010 Dai, 2001, Influence of operating parameters on the use of the microwave-assisted process (MAP) for the extraction of azadirachtin-related limonoids from neem (Azadirachta indica) under atmospheric pressure conditions, Journal of Agricultural and Food Chemistry, 49, 4584, 10.1021/jf010592k Daniel, 2006, Vol. 1 Daniells Das, 2003, 118 Das, 2006 Deepak, 2005, Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC, Phytochemical Analysis, 16, 24, 10.1002/pca.805 Del Serrone, 2015, Neem (Azadirachta indica A. Juss) oil to tackle enteropathogenic Escherichia coli, BioMed Research International, 2015, 10.1155/2015/343610 Devendra, 2018, Brahmi (Bacopa monnieri) as functional food Ingredient in food processing industry, Journal of Pharmacognosy and Phytochemistry, 7, 6 Devkumar, 2007 Dhami, 2017, Withaferin A and its potential role in glioblastoma (GBM), Journal of neuro-oncology, 131, 201, 10.1007/s11060-016-2303-x Dhanani, 2017, Effect of extraction methods on yield, phytochemical constituents and antioxidant activity of Withania somnifera, Arabian Journal of Chemistry, 10, S1193, 10.1016/j.arabjc.2013.02.015 Diaz Maroto, 2003, Influence of drying on the flavor quality of spearmint (Mentha spicata L.), Journal of Agricultural and Food Chemistry, 51, 1265, 10.1021/jf020805l Diaz Maroto, 2003, Influence of drying on the flavor quality of spearmint (Mentha spicata L.), Journal of Agricultural and Food Chemistry, 51, 1265, 10.1021/jf020805l Dinan, 2001, Chromatographic procedures for the isolation of plant steroids, Journal of Chromatography A, 935, 105, 10.1016/S0021-9673(01)00992-X Diop, 2016, Chemical composition of essential oils and floral waters of Mentha longifolia (L.) Huds. from Senegal, American Journal of Essential Oils and Natural Products, 4, 46 Dixie, 2003, Medicinal plant marketing in Bangladesh Dong, 2013, Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway, BMC Complementary and Alternative Medicine, 13, 64, 10.1186/1472-6882-13-64 Dorman, 2010, Ocimum basilicum L.: Phenolic profile and antioxidant-related activity, Natural product communications, 5, 65, 10.1177/1934578X1000500117 Doughari, 2012, Phytochemicals: Extraction methods, basic structures and mode of action as potential chemotherapeutic agents Dowell, 2015, Validation of quantitative HPLC method for bacosides in keenmind, Evidence-based Complementary and Alternative Medicine, 2015, 10.1155/2015/696172 Duband, 1992, Aromatic and polyphenolic composition of infused peppermint, Mentha x piperita L, Vol. 50, 146 Dzoyem, 2017, Chapter 9 - anti-inflammatory and anti-nociceptive activities of african medicinal spices and vegetables, 239 Engels, 2011, Bacopa Ezzat, 2018 Farooqui, 2018, Ayurvedic medicine for the treatment of dementia: Mechanistic aspects, Evidence-based Complementary and Alternative Medicine, 2018, 10.1155/2018/2481076 FutureMarketInsights, 2018, Ginseng market: Global industry analysis and opportunity assessment 2016-2026, Vol. 2018 Fuzzati, 2004, Analysis methods of ginsenosides, Journal of Chromatography B, 812, 119, 10.1016/S1570-0232(04)00645-2 Gajbhiye, 2015, Accumulation of three important bioactive compounds in different plant parts of withania somnifera and its determination by the LC–ESI-MS-MS (MRM) method, Journal of chromatographic science, 53, 1749, 10.1093/chromsci/bmv088 Gambari, 2016, Control of Fungal Leaf Spot disease of mango (Mangifera indica.l) with extracts of Azadirachta indica (neem) and Zingiber officinale (Ginger), E3 Journal of Agricultural Research and Development, 6, 6 Gao, 2012, Differentiating organic from conventional peppermints using chromatographic and flow injection mass spectrometric (FIMS) fingerprints, Journal of Agricultural and Food Chemistry, 60, 11987, 10.1021/jf303415d Ghosh, 2013, Supercritical carbon dioxide extraction of eugenol-rich fraction from Ocimum sanctum Linn and a comparative evaluation with other extraction techniques: Process optimization and phytochemical characterization, Industrial Crops and Products, 47, 78, 10.1016/j.indcrop.2013.02.030 Girish, 2008, Neem–a green treasure, Electronic journal of Biology, 4 Goel, 2008, Curcumin as “curecumin”: From kitchen to clinic, Biochemical Pharmacology, 75, 787, 10.1016/j.bcp.2007.08.016 Gong, 2014, Optimization of the ethanol recycling reflux extraction process for saponins using a design space approach, PloS One, 9, e114300, 10.1371/journal.pone.0114300 Gonçalves, 2014, Use of curcuma longa in cosmetics: Extraction of curcuminoid pigments, development of formulations, and in vitro skin permeation studies, Brazilian Journal of Pharmaceutical Sciences, 50, 885, 10.1590/S1984-82502014000400024 GrandViewResearch, 2018, Vol. 2018 Green, 2008, Extraction, processing, and storage effects on curcuminoids and oleoresin yields from Curcuma longa L. grown in Jamaica, Journal of Agricultural and Food Chemistry, 56, 3664, 10.1021/jf073105v Grieve, 1995, Vol. 2017 Gulati, 2016, Chapter 6 - nutraceuticals in respiratory disorders, 75 Gu, 2003, Minor withanolides from Physalis philadelphica: Structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts, Chemical and Pharmaceutical Bulletin, 51, 530, 10.1248/cpb.51.530 Gupta, 2015, Neutraceuticals as adjunct treatment during chemo-or radio-therapy for cancer: A review, International Journal of Pharmaceutical Sciences and Research, 6, 91 Gupta, 2013, Therapeutic roles of curcumin: Lessons learned from clinical trials, The AAPS Journal, 15, 195, 10.1208/s12248-012-9432-8 Gupta, 2002 Halim, 2006, Effect ofOcimum sanctum (Tulsi) and vitamin E on biochemical parameters and retinopathy in streptozotocin induced diabetic rats, Indian Journal of Clinical Biochemistry, 21, 181, 10.1007/BF02912939 Handa, 2008, Vol. 1 Han, 2014, Fast determination of ginsenosides in ginseng by high‐performance liquid chromatography with chemometric resolution, Journal of Separation Science, 37, 2126, 10.1002/jssc.201400403 Hashmat, 2012, Neem (Azadirachta indica A. Juss)-A nature's drugstore: An overview, International Research Journal of Biological Sciences, 1, 76 Hassan, 2013, Investigation of climate changes on metabolic response of plants; interactive effects of drought stress and excess UV-B, Journal of Earth Science & Climatic Change, 4, 2 Heukelbach, 2006, A new shampoo based on neem (Azadirachta indica) is highly effective against head lice in vitro, Parasitology Research, 99, 353, 10.1007/s00436-006-0146-7 Hewlings, 2017, Curcumin: A review of its' effects on human health, Foods, 6, 92, 10.3390/foods6100092 Hong, 2011, Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes, Immune network, 11, 42, 10.4110/in.2011.11.1.42 Hossain, 2011, Gas chromatography–mass spectrometry analysis of various organic extracts of Merremia borneensis from Sabah, Asian Pacific Journal of Tropical Medicine, 4, 637, 10.1016/S1995-7645(11)60162-4 Hou, 2010, A method of extracting ginsenosides from Panax ginseng by pulsed electric field, Journal of Separation Science, 33, 2707, 10.1002/jssc.201000033 Hou, 2002, Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera, Journal of Natural Products, 65, 1759, 10.1021/np020238w Huang, 2016, Tartaric acid induced conversion of protopanaxadiol to ginsenosides Rg3 and Rg5 and their in situ recoveries by integrated expanded bed adsorption chromatography, Journal of Separation Science, 39, 2995, 10.1002/jssc.201600269 Ikpeama, 2014, Nutritional composition of Tumeric (Curcuma longa) and its antimicrobial properties, International Journal of Scientific Engineering and Research, 5, 1085 Inbaneson, 2012, In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum, Asian Pacific Journal of Tropical Medicine, 5, 103, 10.1016/S1995-7645(12)60004-2 Izadiyan, 2016, Multi-response optimization of factors affecting ultrasonic assisted extraction from Iranian basil using central composite design, Food Chemistry, 190, 864, 10.1016/j.foodchem.2015.06.036 Jadad, 1996, Assessing the quality of reports of randomized clinical trials: Is blinding necessary?, Controlled Clinical Trials, 17, 1, 10.1016/0197-2456(95)00134-4 Jadeja, 2011, Extraction of natural insecticide azadirachtin from neem (Azadirachta indica A. Juss) seed kernels using pressurized hot solvent, The Journal of Supercritical Fluids, 56, 253, 10.1016/j.supflu.2011.01.004 Jain, 1994, Antiinflammatory effects of an ayurvedic preparation, brahmi rasayan, in rodents, Indian Journal of Experimental Biology, 32, 633 Jeandet, 2012, Metabolic engineering of yeast and plants for the production of the biologically active hydroxystilbene, resveratrol, Journal of BioMed Research, 2012 Joshi, 2011, Phytochemical extraction and antimicrobial properties of different medicinal plants: Ocimum sanctum (Tulsi), Eugenia caryophyllata (Clove), Achyranthes bidentata (Datiwan) and Azadirachta indica (Neem), Journal of Microbiology and Antimicrobials, 3, 1 Joshi, 2014, Azadirachta indica leaves as antibacterial treatment on drinking water, Nternational Journal of Clinical Nutrition, 2, 5 Joshi, 2017, Phytoconstituents, traditional medicinal uses and bioactivities of tulsi (ocimum sanctum Linn.): A review, American Journal of Essential Oils and Natural Products, 5, 18 Kanungo, 2014, Evaluation of the price differences of turmeric across India, a statistical analysis, IOSR Journal of Business and Management, 16, 4, 10.9790/487X-16734245 Kapp, 2015 Katsuyama, 2009, Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa, Journal of Biological Chemistry, 284, 11160, 10.1074/jbc.M900070200 Kaufmann, 2001, Parameters affecting microwave‐assisted extraction of withanolides, Phytochemical Analysis, 12, 327, 10.1002/pca.599 Kaul, 2016, Novel methods to generate active ingredients-enriched Ashwagandha leaves and extracts, PloS One, 11, e0166945, 10.1371/journal.pone.0166945 Kean, 2017, Systematic overview of bacopa monnieri (L.) wettst. Dominant poly-herbal formulas in children and adolescents, Medicine, 4, 86 Kee, 2017 Kelm, 2000, Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn, Phytomedicine, 7, 7, 10.1016/S0944-7113(00)80015-X Khan, 2015, Ginsenosides as food supplements and their potential role in immunological and neurodegenerative disorders, 303 Kim, 2012, Cardiovascular diseases and Panax ginseng: A review on molecular mechanisms and medical applications, Journal of ginseng research, 36, 16, 10.5142/jgr.2012.36.1.16 Kim, 2013, Optimization and validation of high-performance liquid chromatography method for individual curcuminoids in turmeric by heat-refluxed extraction, Journal of Agricultural and Food Chemistry, 61, 10911, 10.1021/jf402483c Klinger, 2016, Therapeutic potential of curcumin for the treatment of brain tumors, Oxidative medicine and cellular longevity, 2016, 10.1155/2016/9324085 Kole, 2005 Koshy, 2016, Determination of withanolides in withania somnifera by liquid chromatography: Single-laboratory validation, first action 2015.17, Journal of AOAC International, 99, 1444, 10.5740/jaoacint.16-0202 Košťálová, 2013, Therapeutic potential of curcumin in medicinal chemistry, Acta Chimica Slovaca, 6, 89, 10.2478/acs-2013-0015 Kothari, 2004, Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum Lf (syn. O. sanctum L.) grown in south India as influenced by method of harvest, Journal of Chromatography A, 1054, 67, 10.1016/j.chroma.2004.03.019 Koul, 1990, Properties and uses of neem, Azadirachta indica, Canadian Journal of Botany, 68, 1, 10.1139/b90-001 Kpoviessi, 2012, Chemical variation of essential oil constituents of Ocimum gratissimum L. from Benin, and Impact on Antimicrobial Properties and Toxicity against Artemia salinaLeach, Chemistry and Biodiversity, 9, 139, 10.1002/cbdv.201100194 Krishnamurthy, 2010, Proximate nutritive values and mineral components of Withania somnifera (Linn.) Dunal, Journal of Chemistry, 7, 985 Krishnaswamy, 1996, Indian functional foods: Role in prevention of cancer, Nutrition Reviews, 54, S127, 10.1111/j.1753-4887.1996.tb03832.x Kuang, 2012, Separation and purification of ginsenoside Re from ginseng bud by selective adsorption of active carbon and preparative high-performance liquid chromatography, Natural Product Research, 26, 286, 10.1080/14786419.2010.540577 Kuete, 2017, Chapter 13 - other health benefits of african medicinal spices and vegetables, 329 Kumar, 2011 Kumari, 2016 Kumar, 2012, Pharmacological actions of ocimum sacntum– review article, International Journal of Advances in Pharmacy, Biology and Chemistry, 1, 9 Kumar, 2013, Ocimum sanctum (tulsi): A miracle herb and boon to medical science–A review, International Journal of Agronomy and Plant Production, 4, 1580 Kunnumakkara, 2009, Mint and its constituents, 373 Kwon, 2015, Pilot-scale subcritical solvent extraction of curcuminoids from Curcuma long L, Food Chemistry, 185, 58, 10.1016/j.foodchem.2015.03.114 Lechtenberg, 2004, Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis, Phytochemical Analysis, 15, 152, 10.1002/pca.759 Lee, 2011, A comparison between high hydrostatic pressure extraction and heat extraction of ginsenosides from ginseng (Panax ginseng CA Meyer), Journal of the Science of Food and Agriculture, 91, 1466, 10.1002/jsfa.4334 Lee, 2013, Curcumin and its derivatives: Their application in neuropharmacology and neuroscience in the 21st century, Current Neuropharmacology, 11, 338, 10.2174/1570159X11311040002 Ligor, 2005, Isolation and determination of ginsenosides in American ginseng leaves and root extracts by LC-MS, Analytical and Bioanalytical Chemistry, 383, 1098, 10.1007/s00216-005-0120-8 Li, 2008, Effective purification of ginsenosides from cultured wild ginseng roots, red ginseng, and white ginseng with macroporous resins, Journal of Microbiology and Biotechnology, 18, 1789 Li, 2017, A strategy for simultaneous isolation of less polar ginsenosides, including a pair of new 20-methoxyl isomers, from flower buds of Panax ginseng, Molecules, 22, 442, 10.3390/molecules22030442 Li, 2014, Optimisation of pulsed ultrasonic and microwave-assisted extraction for curcuminoids by response surface methodology and kinetic study, Food Chemistry, 165, 29, 10.1016/j.foodchem.2014.03.115 Lin, 2013, Aqueous ionic liquid based ultrasonic assisted extraction of eight ginsenosides from ginseng root, Ultrasonics Sonochemistry, 20, 680, 10.1016/j.ultsonch.2012.10.003 Liu, 2017, The beneficial effect of ginsenosides extracted by pulsed electric field against hydrogen peroxide-induced oxidative stress in HEK-293 cells, Journal of ginseng research, 41, 169, 10.1016/j.jgr.2016.02.007 Li, 2009, [Analysis of minor curcuminoids in Curcuma longa L. by high performance liquid chromatography-tandem mass spectrometry], Se Pu, 27, 6 Lucchesi, 2004, Solvent-free microwave extraction of essential oil from aromatic herbs: Comparison with conventional hydro-distillation, Journal of Chromatography A, 1043, 323, 10.1016/j.chroma.2004.05.083 Lussier, 2012, Engineering microbes for plant polyketide biosynthesis, Computational and Structural Biotechnology Journal, 3, e201210020, 10.5936/csbj.201210020 Lu, 2009, Ginseng compounds: An update on their molecular mechanisms and medical applications, Current Vascular Pharmacology, 7, 293, 10.2174/157016109788340767 Lv, 2012, Phenolic composition and nutraceutical properties of organic and conventional cinnamon and peppermint, Food Chemistry, 132, 1442, 10.1016/j.foodchem.2011.11.135 MacCrehan, 2013, Simplified ultrasonically-and microwave-assisted solvent extractions for the determination of ginsenosides in powdered Panax ginseng rhizomes using liquid chromatography with UV absorbance or electrospray mass spectrometric detection, Analytical and Bioanalytical Chemistry, 405, 4511, 10.1007/s00216-013-6871-8 Mahboub, 2014, Structural conformational study of eugenol derivatives using semiempirical methods, Advances in Chemistry, 2014, 10.1155/2014/490358 Majeed, 2015, Vol. 2017 Mak Mensah, 2011, Chemical characteristics of toilet soap prepared from neem (Azadirachta indica A. Juss) seed oil, Asian Journal of Plant Science & Research, 1, 1 Malishev, 2016, Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858, 2208, 10.1016/j.bbamem.2016.06.019 Mallick, 2015, Evaluation of anticancer potential of Bacopa monnieri L. against MCF-7 and MDA-MB 231 cell line, Journal of Pharmacy & Bioallied Sciences, 7, 325, 10.4103/0975-7406.168038 Manzan, 2003, Extraction of essential oil and pigments from Curcuma longa [L.] by steam distillation and extraction with volatile solvents, Journal of Agricultural and Food Chemistry, 51, 6802, 10.1021/jf030161x McKay, 2006, A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.), Phytotherapy Research, 20, 619, 10.1002/ptr.1936 Mirjalili, 2009, Steroidal lactones from Withania somnifera, an ancient plant for novel medicine, Molecules, 14, 2373, 10.3390/molecules14072373 Mirzajani, 2010, Optimisation of a microwave‐assisted method for extracting withaferin A from Withania somnifera Dunal. using central composite design, Phytochemical Analysis, 21, 544, 10.1002/pca.1230 Mishra, 2000, Scientific basis for the therapeutic use of withania somnifera (ashwagandha): A review, Alternative Medicine Review, 5, 334 Mi, 2013, Coupling of ultrasound‐assisted extraction and expanded bed adsorption for simplified medicinal plant processing and its theoretical model: Extraction and enrichment of ginsenosides from Radix Ginseng as a case study, Journal of Separation Science, 36, 593, 10.1002/jssc.201200745 Mohammed, 2014, Rubiothiazepine a novel unusual cytotoxic alkaloid from Ixora undulata Roxb. leaves, Natural Products Chemistry & Research, 2, 128, 10.4172/2329-6836.1000128 Mohana, 2016 Mucalo, 2012, Effect of American ginseng (Panax quinquefolius L.) on glycemic control in type 2 diabetes, Collegium Antropologicum, 36, 1435 Nagpal, 2013, Role of curcumin in systemic and oral health: An overview, Journal of Natural Science, Biology, and Medicine, 4, 3, 10.4103/0976-9668.107253 Namdev, 2015, Herbal green tea formulation using Withania somnifera stems, Terminalia arjuna bark, Cinnamon bark and Tinospora cordifolia stems and nutritional & phytochemical analysis, Journal of Pharmacognosy and Phytochemistry, 4 Narinderpal, 2013, A Review on pharmacological profile of Withania somnifera (Ashwagandha), Research Reviews Journal of Botanical Science, 2, 6 Nasri, 2014, New concepts in nutraceuticals as alternative for pharmaceuticals, International Journal of Preventive Medicine, 5, 1487 NationalResearchCouncil, 1992, Industrial products Nature&Garden, 2018, Ginseng health benefits and therapeutic properties, Vol. 2018 Neale, 2013, Cognitive effects of two nutraceuticals ginseng and bacopa benchmarked against modafinil: A review and comparison of effect sizes, British Journal of Clinical Pharmacology, 75, 728, 10.1111/bcp.12002 Nguyen, 2017, Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides, Food Chemistry, 214, 366, 10.1016/j.foodchem.2016.07.102 Oleszek, 2000 Oman, 2013, Application of supercritical fluid extraction for the separation of nutraceuticals and other phytochemicals from plant material, Macedonian Journal of Chemistry and Chemical Engineering, 32, 44, 10.20450/mjcce.2013.443 Omosa, 2017, Chapter 19 - curcuma longa, 425 Osorio-Tobón, 2016, Fast analysis of curcuminoids from turmeric (Curcuma longa L.) by high-performance liquid chromatography using a fused-core column, Food Chemistry, 200, 167, 10.1016/j.foodchem.2016.01.021 Paek, 2009, Large scale culture of ginseng adventitious roots for production of ginsenosides, 151 Palaniyandi, 2017, Preparation of ginseng extract with enhanced levels of ginsenosides Rg1 and Rb1 using high hydrostatic pressure and polysaccharide hydrolases, Pharmacognosy Magazine, 13, S142, 10.4103/0973-1296.203992 Palliyaguru, 2016, Withania somnifera: From prevention to treatment of cancer, Molecular Nutrition & Food Research, 60, 1342, 10.1002/mnfr.201500756 Pandey, 2017, Withania somnifera: Advances and implementation of molecular and tissue culture techniques to enhance its application, Frontiers of Plant Science, 8, 1390, 10.3389/fpls.2017.01390 Pandit, 2013, Effects of Withania somnifera on the growth and virulence properties of Streptococcus mutans and Streptococcus sobrinus at sub-MIC levels, Anaerobe, 19, 1, 10.1016/j.anaerobe.2012.10.007 Parale, 2010, Influence of organic supplements on production of shoot and callus biomass and accumulation of bacoside in Bacopa monniera (L.) Pennell, Physiology and Molecular Biology of Plants, 16, 167, 10.1007/s12298-010-0018-6 Park, 2013, Potentiation of antioxidative and anti‐inflammatory properties of cultured wild ginseng root extract through probiotic fermentation, Journal of Pharmacy and Pharmacology, 65, 457, 10.1111/jphp.12004 Patil, 2011, Current trends and future prospective of nutraceuticals in health promotion, BIOINFO Pharmaceutical Biotechnology, 1 Patil, 2013, Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics after oral administration of withania somnifera aqueous extract, Journal of Pharmaceutical and Biomedical Analysis, 80, 203, 10.1016/j.jpba.2013.03.001 Pattanayak, 2010, Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview, Pharmacognosy Reviews, 4, 95, 10.4103/0973-7847.65323 de Paula, 2016, Ultrasound-assisted extraction of azadirachtin from dried entire fruits of Azadirachta indica A. Juss.(Meliaceae) and its determination by a validated HPLC-PDA method, Talanta, 149, 77, 10.1016/j.talanta.2015.11.005 Paul, 2011, An updated overview on peppermint (mentha piperita l.), International Research Journal of Pharmacy, 2, 10 Pedro, 2016, Extraction of bioactive compounds and free radical scavenging activity of purple basil (Ocimum basilicum L.) leaf extracts as affected by temperature and time, Anais da Academia Brasileira de Ciências, 88, 1055, 10.1590/0001-3765201620150197 Peixoto, 2010, Potential pharmacological and toxicological basis of the essential oil from Mentha spp, Revista de Ciências Farmacêuticas Básica e Aplicada, 30, 235 Pérez, 2014, Effect of chemical elicitors on peppermint (Mentha piperita) plants and their impact on the metabolite profile and antioxidant capacity of resulting infusions, Food Chemistry, 156, 273, 10.1016/j.foodchem.2014.01.101 Polasa, 1991, Turmeric (Curcuma longa)-induced reduction in urinary mutagens, Food and Chemical Toxicology, 29, 699, 10.1016/0278-6915(91)90128-T Prakash, 2002, Production of azadirachtin from plant tissue culture: State of the art and future prospects, Biotechnology and Bioprocess Engineering, 7, 185, 10.1007/BF02932968 Prakash, 2008, Production of biopesticides in an in situ cell retention bioreactor, Applied Biochemistry and Biotechnology, 151, 307, 10.1007/s12010-008-8191-6 Prasad, 2011 Prashant, 2007, The effect of mango and neem extract on four organisms causing dental caries: Streptococcus mutans, Streptococcus salivavius, Streptococcus mitis, and Streptococcus sanguis: An in vitro study, Indian Journal of Dental Research, 18, 148, 10.4103/0970-9290.35822 Prosen, 1999, Solid-phase microextraction, TRAC Trends in Analytical Chemistry, 18, 272, 10.1016/S0165-9936(98)00109-5 Qi, 2011, Ginsenosides from american ginseng: Chemical and pharmacological diversity, Phytochemistry, 72, 689, 10.1016/j.phytochem.2011.02.012 Rabhi, 2015, Antiangiogenic-like properties of fermented extracts of ayurvedic medicinal plants, Journal of Medicinal Food, 18, 1065, 10.1089/jmf.2014.0128 Ragasa, 1997, Tetranortriterpenoids from Azadirachta indica, Phytochemistry, 46, 555, 10.1016/S0031-9422(97)87092-6 Rajan, 2015, Molecular and functional characterization of bacopa monniera: A retrospective review, Evidence-based Complementary and Alternative Medicine, 2015, 10.1155/2015/945217 Rajasekar, 2011, Estimation of alkaloid content of Ashwagandha (Withania somnifera) with HPLC methods, Journal of Experimental Sciences, 2 Ramalingum, 2014, The therapeutic potential of medicinal foods, Advances in pharmacological sciences, 2014, 10.1155/2014/354264 Ramawat, 2004 Ranjan, 2018, To study the physico-chemical properties of Ashwagandha enriched pineapple ice cream, International Journal of Chemical Studies, 6, 6 Rastogi, 1998, Vol. 6 Raut, 2012, Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers, Journal of Ayurveda and Integrative Medicine, 3, 111, 10.4103/0975-9476.100168 Riachi, 2012, Volatile composition of peppermint (Mentha piperita L.) commercial teas through solid phase extraction, Archivos Latinoamericanos de Nutricion, 62, 389 Riedmaier, 2013, Metformin and cancer: From the old medicine cabinet to pharmacological pitfalls and prospects, Trends in Pharmacological Sciences, 34, 126, 10.1016/j.tips.2012.11.005 Rizvi, 2013, Traditional Indian medicines used for the management of diabetes mellitus, Journal of diabetes research, 2013 Rodrigues, 2015, Heterologous production of curcuminoids, Microbiology and Molecular Biology Reviews, 79, 39, 10.1128/MMBR.00031-14 Rohloff, 2002, Essential oil composition of sachalinmint from Norway detected by solid-phase microextraction and gas chromatography− mass spectrometry analysis, Journal of Agricultural and Food Chemistry, 50, 1543, 10.1021/jf011255e Ruiz del Castillo, 2003, A comparative study of the ability of different techniques to extract menthol from Mentha piperita, Journal of chromatographic science, 41, 385, 10.1093/chromsci/41.7.385 Sachdeva, 2018, Emerging trends of herbs and spices in dentistry, Biomedical Journal of Scientific & Technical Research, 4, 5, 10.26717/BJSTR.2018.04.0001125 Sakamoto, 2017 Saleem, 2016, Podina (Mentha arvensis): Transformation from food additive to multifunctional medicine, ARC Journal of Pharmaceutical Sciences (AJPS), 2, 10 Samadi, 2015, Potential anticancer properties and mechanisms of action of withanolides, Vol. 37, 73 Šarić-Kundalić, 2009, Multivariate numerical taxonomy of Mentha species, hybrids, varieties and cultivars, Scientia Pharmaceutica, 77, 851, 10.3797/scipharm.0905-10 Sarker, 2006, Vol. 20 Sasidharan, 2011, Extraction, isolation and characterization of bioactive compounds from plants' extracts, African Journal of Traditional, Complementary and Alternative Medicines, 8 Saxena, 2010, Purification of Azadirachta indica seed cake and its impact on nutritional and antinutritional factors, Journal of Agricultural and Food Chemistry, 58, 4939, 10.1021/jf904336k Schefer, 2006, Application of high-performance liquid chromatography–nuclear magnetic resonance coupling to the identification of limonoids from mahogany tree (Switenia macrophylla, Meliaceae) by stopped-flow 1D and 2D NMR spectroscopy, Journal of Chromatography A, 1128, 152, 10.1016/j.chroma.2006.06.059 Schmidt, 2012, Responsible use of medicinal plants for cosmetics, HortScience, 47, 985, 10.21273/HORTSCI.47.8.985 Schmutterer, 1995 Sederma, 2018 Sengupta, 2017, Role of Withania somnifera (Ashwagandha) in the management of male infertility, Reproductive Biomedicine Online, 36, 311, 10.1016/j.rbmo.2017.11.007 Shao, 2013, Potential serious interactions between nutraceutical ginseng and warfarin in patients with ischemic stroke, Trends in Pharmacological Sciences, 34, 85, 10.1016/j.tips.2012.11.008 Sharma, 2001, Antifertility investigation and toxicological screening of the petroleum ether extract of the leaves of Mentha arvensis L. in male albino mice, Journal of Ethnopharmacology, 75, 5, 10.1016/S0378-8741(00)00362-7 Shasany, 2016, The Holy basil (Ocimum sanctum L.) and its genome, Indian Journal of History of Science, 51, 343, 10.16943/ijhs/2016/v51i2.2/48446 Shehzad, 2011, Development of a rapid and convenient method to separate eight ginsenosides from Panax ginseng by high‐speed counter‐current chromatography coupled with evaporative light scattering detection, Journal of Separation Science, 34, 1116, 10.1002/jssc.201000932 Shehzad, 2013, State-of-the-art separation of ginsenosides from Korean white and red ginseng by countercurrent chromatography, Analytical and Bioanalytical Chemistry, 405, 4523, 10.1007/s00216-012-6609-z Shen, 2013, Simultaneous determination of three Curcuminoids in Curcuma wenyujin YH chen et C. Ling. by liquid chromatography–tandem mass spectrometry combined with pressurized liquid extraction, Journal of Pharmaceutical and Biomedical Analysis, 81, 146, 10.1016/j.jpba.2013.03.027 Shi, 2011, Matrix solid phase dispersion extraction of ginsenosides in the leaves of Panax ginseng CM Mey, Food Chemistry, 129, 1253, 10.1016/j.foodchem.2011.04.067 Shin, 2017, Anti-skin-aging activity of a standardized extract from Panax ginseng leaves in vitro and in human volunteer, Cosmetics, 4, 18, 10.3390/cosmetics4020018 Shiwakoti, 2017, Yield, composition and antioxidant capacity of the essential oil of sweet basil and holy basil as influenced by distillation methods, Chemistry and Biodiversity, 14, 10.1002/cbdv.201600417 Shu, 2016, Separation of curcuminoids using ionic liquid based aqueous two-phase system coupled with in situ dispersive liquid–liquid microextraction, Talanta, 149, 6, 10.1016/j.talanta.2015.11.009 Sidhu, 2003, Variability in neem (Azadirachta indica) with respect to azadirachtin content, Journal of Agricultural and Food Chemistry, 51, 910, 10.1021/jf025994m Silver, 2007, CHAPTER 6 - ayurvedic veterinary medicine: Principles and practices, 59 Singh-Verma, S.B. (2001). Cosmetic formulations containing extracts from Phyllanthus emblica and Centella asiatica and/or Bacopa monnieri. In U. S. Patent (Ed.), (Vol. US 6,361,804 B2). USA: Shyam B. Singh-Verma. Singh, 2013, Nutraceuticals: Promising health product, International Research Journal of Medical Sciences, 1, 4 Singh, 2012, Diversified potentials of Ocimum sanctum Linn (Tulsi): An exhaustive survey, Journal of Natural Product and Plant Resources, 2, 39 Singh, 2006, Regeneration of plants from alginate-encapsulated shoot tips of Withania somnifera (L.) Dunal, a medicinally important plant species, Journal of Plant Physiology, 163, 220, 10.1016/j.jplph.2005.06.013 Singh, 2012, Therapeutic potential of Ocimum sanctum in prevention and treatment of cancer and exposure to radiation: An overview, International Journal of Pharmaceutical Sciences and Drug Research, 4, 97 Sithisarn, 2006, Comparison of free radical scavenging activity of Siamese neem tree (Azadirachta indica A. Juss var. siamensis Valeton) leaf extracts prepared by different methods of extraction, Medical Principles and Practice, 15, 219, 10.1159/000092185 Sivaramakrishna, 2005, Triterpenoid glycosides from Bacopa monnieri, Phytochemistry, 66, 2719, 10.1016/j.phytochem.2005.09.016 Skalicka-Woźniak, 2014, Preparative separation of menthol and pulegone from peppermint oil (Mentha piperita L.) by high-performance counter-current chromatography, Phytochemistry Letters, 10, 10.1016/j.phytol.2014.06.007 Skin Inc, 2008, Turmeric's therapeutic benefit in cosmetics, Vol. 2018 Song, 2017, Microbial transformation of ginsenosides extracted from Panax ginseng adventitious roots in an airlift bioreactor, Electronic Journal of Biotechnology, 26, 20, 10.1016/j.ejbt.2016.12.005 Soquetta, 2018, Green technologies for the extraction of bioactive compounds in fruits and vegetables, CyTA - Journal of Food, 16, 400, 10.1080/19476337.2017.1411978 de Sousa Guedes, 2016, The efficacy of Mentha arvensis L. and M. piperita L. essential oils in reducing pathogenic bacteria and maintaining quality characteristics in cashew, guava, mango, and pineapple juices, International Journal of Food Microbiology, 238, 183, 10.1016/j.ijfoodmicro.2016.09.005 de Souza Tavares, 2016, Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists, Scientific Reports, 6, 34093, 10.1038/srep34093 SpecialChem, 2018, Mentha spicata flower/leaf/stem extract SpecialChem Srivastava, 2013, Production of the biopesticide azadirachtin by hairy root cultivation of Azadirachta indica in liquid-phase bioreactors, Applied Biochemistry and Biotechnology, 171, 1351, 10.1007/s12010-013-0432-7 Straumite, 2015, Pigments in mint leaves and stems, Agronomy Research, 13, 1104 Suanarunsawat, 2010, Anti-hyperlipidemic and cardioprotective effects of Ocimum sanctum L. fixed oil in rats fed a high fat diet, Journal of Basic and Clinical Physiology and Pharmacology, 21, 387, 10.1515/JBCPP.2010.21.4.387 Subramanian, 2014, Studies of antimicrobial properties of different leaf extract of tulsi (ocimum tenuiflorum) against human pathogens, American International Journal of Contemporary Research, 4, 149 Sujarwo, 2016, Ethnobotanical uses of neem (Azadirachta indica A. Juss.; Meliaceae) leaves in Bali (Indonesia) and the Indian subcontinent in relation with historical background and phytochemical properties, Journal of Ethnopharmacology, 189, 186, 10.1016/j.jep.2016.05.014 Sun, 2008, Effect of Rhizoma curcumae oil on the learning and memory in rats exposed to chronic hypoxia and the possible mechanisms, Sheng li xue bao:[Acta physiologica Sinica], 60, 228 Sunwoo, 2013, Extraction of ginsenosides from fresh ginseng roots (Panax ginseng CA Meyer) using commercial enzymes and high hydrostatic pressure, Biotechnology Letters, 35, 1017, 10.1007/s10529-013-1182-x Tarhan, 2010, Product quality and energy consumption when drying peppermint by rotary drum dryer, Industrial Crops and Products, 32, 420, 10.1016/j.indcrop.2010.06.003 Tayyem, 2006, Curcumin content of turmeric and curry powders, Nutrition and Cancer, 55, 126, 10.1207/s15327914nc5502_2 Thatoi, 2011, Biotechnology and pharmacological evaluation of medicinal plants: An overview, Journal of Herbs, Spices, & Medicinal Plants, 17, 214, 10.1080/10496475.2011.602471 TheGoodScentsCompany, 2018 Thimmayamma, 1983, Use of spices and condiments in the dietaries of urban and rural families [India], The Indian Journal of Nutrition and Dietetics, 20, 153 Tigrine-Kordjani, 2006, Microwave ‘dry’distillation as an useful tool for extraction of edible essential oils, International Journal of Aromatherapy, 16, 141, 10.1016/j.ijat.2006.09.007 Tiwari, 2014, Ashwagandha (withania somnifera): Role in safeguarding health, immunomodulatory effects, combating infections and therapeutic applications: A review, Journal of Biological Sciences, 14, 77, 10.3923/jbs.2014.77.94 Tiwari, 2018, Therapeutic recognition of nutraceuticals for health benefits and economic uplifment of farming community, International Journal of Current Microbiology and Applied Sciences, 7, 8, 10.20546/ijcmas.2018.708.496 UltraInternational, 2016, Vol. 2018 UnitedStates Department of Agriculture, 2018, Basil, fresh USDA, A. R. S, 2017, Taxon: Withania somnifera (L.) dunal. Germplasm resources information network (GRIN-Taxonomy), Vol. 2017 Van der Nat, 1989, Characterization of anti-complement compounds from Azadirachta indica, Journal of Ethnopharmacology, 27, 15, 10.1016/0378-8741(89)90073-1 Van der Nat, 1991, Activity-guided isolation and identification of Azadirachta indica bark extract constituents which specifically inhibit chemiluminescence production by activated human polymorphonuclear leukocytes, Planta Medica, 57, 65, 10.1055/s-2006-960021 Vásquez-Rivera, 2015, Production of limonoids with insect antifeedant activity in a two-stage bioreactor process with cell suspension culture of Azadirachta indica, Applied Biochemistry and Biotechnology, 177, 334, 10.1007/s12010-015-1745-5 Verma, 2011, Therapeutic uses of Withania somnifera (ashwagandha) with a note on withanolides and its pharmacological actions, Asian Journal of Pharmaceutical and Clinical Research, 4, 1 Villegas, 2008, New mechanisms and therapeutic potential of curcumin for colorectal cancer, Molecular Nutrition & Food Research, 52, 1040, 10.1002/mnfr.200700280 Wang, 2008, Analysis of ginsenosides in Panax ginseng in high pressure microwave-assisted extraction, Food Chemistry, 110, 161, 10.1016/j.foodchem.2008.01.028 Wang, 2015, Comparison of chemical components of essential oil from ocimum basilicum var. pilosum extracted by supercritical CO2 fluid and steam distillation, Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials, 38, 2327 Wankhede, 2015, Examining the effect of withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial, Journal of the International Society of Sports Nutrition, 12, 43, 10.1186/s12970-015-0104-9 Wan, 2006, Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD, Journal of Pharmaceutical and Biomedical Analysis, 41, 1596, 10.1016/j.jpba.2006.01.058 Warra, 2012, Medical and cosmetic potential of neem (azadiracta indica) seed oil: A review, research and review, Journal of Medicinal Chemistry, 1, 4 Weber, 2006, TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin, Biochemical Pharmacology, 72, 928, 10.1016/j.bcp.2006.07.007 Wu, 2001, Ultrasound-assisted extraction of ginseng saponins from ginseng roots and cultured ginseng cells, Ultrasonics Sonochemistry, 8, 347, 10.1016/S1350-4177(01)00066-9 Xie, 2009, Study on extraction and purification process of total ginsenosides from Radix Ginseng, Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials, 32, 1602 Xu, 2016, Extraction and enrichment of natural pigments from solid samples using ionic liquids and chitosan nanoparticles, Journal of Chromatography A, 1463, 32, 10.1016/j.chroma.2016.08.012 Yadav, 2017, Purity evaluation of curcuminoids in the turmeric extract obtained by accelerated solvent extraction, Journal of AOAC International, 100, 586, 10.5740/jaoacint.17-0057 Yadegarinia, 2006, Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils, Phytochemistry, 67, 1249, 10.1016/j.phytochem.2006.04.025 Yallapu, 2012, Curcumin nanoformulations: A future nanomedicine for cancer, Drug Discovery Today, 17, 71, 10.1016/j.drudis.2011.09.009 Yang, 2017, A comprehensive review of micro-distillation methods, Chemical Engineering Journal, 313, 1509, 10.1016/j.cej.2016.11.041 Yao, 2016, An optimized microwave-assisted extraction method for increasing yields of rare ginsenosides from Panax quinquefolius L, Journal of ginseng research, 40, 415, 10.1016/j.jgr.2016.06.007 YCharts, 2018, Vol. 2018 Yuan, 2016, Component analysis and target cell-based neuroactivity screening of Panax ginseng by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry, Journal of Chromatography B, 1038, 1, 10.1016/j.jchromb.2016.10.014 Yue, 2014, Study on extracting and separating curcuminoids from Curcuma longa rhizome using ultrasound strengthen by microemulsion, Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials, 37, 880 Zhang, 2006, Comparative analysis of ginsenosides from red ginseng, Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica, 31, 886 Zhang, 2006, Ginsenoside extraction from Panax quinquefolium L.(American ginseng) root by using ultrahigh pressure, Journal of Pharmaceutical and Biomedical Analysis, 41, 57, 10.1016/j.jpba.2005.10.043 Zhang, 2013, Pressurized liquid extraction coupled with countercurrent chromatography for systematic isolation of chemical constituents by preprogrammed automatic control, Journal of Chromatography B, 935, 16, 10.1016/j.jchromb.2013.07.018 Zhang, 2018, Techniques for extraction and isolation of natural products: A comprehensive review, Chinese Medicine, 13, 20, 10.1186/s13020-018-0177-x Zhang, 2017, Extraction, isolation, and aromatase inhibitory evaluation of low-polar ginsenosides from Panax ginseng leaves, Journal of Chromatography A, 1483, 20, 10.1016/j.chroma.2016.12.068 Zhou, 2015, Extraction optimization of rhizome of curcuma longa by response surface methodology and support vector regression, Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials, 38, 2611 Zhou, 2007, Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models, Journal of Natural Products, 70, 652, 10.1021/np060470s Zhu, 2014, Dynamic predictive modeling of extraction process for red ginseng using near-infrared spectroscopy, Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica, 39, 2660 ZionMarketResearch, 2016, Vol. 2018 Zlabur, 2016, Ultrasound-assisted extraction of bioactive compounds from lemon balm and peppermint leaves, International Agrophysics, 30, 95, 10.1515/intag-2015-0077 Złotek, 2016, The effect of different solvents and number of extraction steps on the polyphenol content and antioxidant capacity of basil leaves (Ocimum basilicum L.) extracts, Saudi Journal of Biological Sciences, 23, 628, 10.1016/j.sjbs.2015.08.002