Segmental Tandem Triplication of the MLL Gene in an Intravascular Large B-Cell Lymphoma With Multisystem Involvement: A Comprehensive Morphologic, Immunophenotypic, Cytogenetic, and Molecular Cytogenetic Antemortem Study

Archives of Pathology and Laboratory Medicine - Tập 133 Số 9 - Trang 1477-1482 - 2009
Jeremy Deisch1, Franklin“Buddy” Fuda1, Weina Chen1, Nitin J. Karandikar1, Arnaldo Arbini1, Xin J. Zhou1, Huan‐You Wang1,2
1From the Department of Pathology, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.
2Reprints: Huan-You Wang, MD, PhD, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 ([email protected]).

Tóm tắt

Abstract An association between intravascular large B-cell lymphoma (IVLBCL) and the mixed lineage leukemia (MLL) gene has never been demonstrated. Here, we report an IVLBCL in a 47-year-old Asian man. Morphologically, the atypical lymphoid infiltrate was entirely confined in the lumina of capillaries, small vessels, and sinusoidal space. Within the kidney, the neoplastic lymphoid cells exhibited both the glomerular and peritubular capillary distribution pattern. Conventional cytogenetic analysis from the bone marrow aspirates displayed a complex karyotype, with a notable triple tandem repeat at band segment q22–q25 of chromosome 11. Fluorescence in situ hybridization with an MLL probe set, performed on both interphase cells and metaphase spreads, confirmed the presence of 3 copies of the MLL gene on the derivative chromosome 11. From this finding and 3 other IVLBCL cases reported in the literature, we conclude that MLL may play an important role in the lymphomagenesis of IVLBCL at least in a subset of cases.

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Tài liệu tham khảo

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Archives of Pathology and Laboratory Medicine

Tập 133 Số 9

1477-1482

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