Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Cancer Discovery - Tập 7 Số 9 - Trang 984-998 - 2017
Kondrashova, Olga1,2, Nguyen, Minh3, Shield-Artin, Kristy1,2, Tinker, Anna V.4, Teng, Nelson N.H.5, Harrell, Maria I.6, Kuiper, Michael J.7, Ho, Gwo-Yaw1,2,8, Barker, Holly1,2, Jasin, Maria9, Prakash, Rohit9, Kass, Elizabeth M.9, Sullivan, Meghan R.10, Brunette, Gregory J.10, Bernstein, Kara A.10, Coleman, Robert L.11, Floquet, Anne12, Friedlander, Michael13, Kichenadasse, Ganessan14, O'Malley, David M.15, Oza, Amit16, Sun, James17, Robillard, Liliane3, Maloney, Lara3, Bowtell, David18,19,20, on behalf of the AOCS Study Group, Giordano, Heidi3, Wakefield, Matthew J.1,7, Kaufmann, Scott H.21, Simmons, Andrew D.3, Harding, Thomas C.3, Raponi, Mitch3, McNeish, Iain A.22, Swisher, Elizabeth M.6, Lin, Kevin K.3, Scott, Clare L.1,2,8
1Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
2Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia
3Clovis Oncology, Inc., Boulder, Colorado.
4British Columbia Cancer Agency Vancouver, British Columbia, Canada
5Stanford University, Palo Alto, California
6University of Washington, Seattle, Washington
7Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia.
8Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
9Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
10Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
11The University of Texas MD Anderson Cancer Center, Houston, Texas
12Institut Bergonié, Bordeaux, France
13University of New South Wales and Prince of Wales Hospital, Sydney, New South Wales, Australia.
14 Flinders University, Adelaide, South Australia, Australia.
15The Ohio State University, James Cancer Center, Columbus, Ohio.
16Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
17Foundation Medicine Inc, Cambridge, Massachusetts
18Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
19Centre for Cancer Research, University of Sydney at Westmead Millennium Institute, and Departments of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
20QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
21Mayo Clinic Cancer Center, Rochester, Minnesota.
22Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

Tài liệu tham khảo

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