Screening and Assessing 11 Mycobacterium tuberculosis Proteins as Potential Serodiagnostical Markers for Discriminating TB Patients from BCG Vaccinees

2009, 7 Hussain, 1997, Immune response profile in patients with active tuberculosis in a BCG vaccinated area, Southeast Asian J. Trop. Med. Public Health, 28, 764 Lyashchenko, 1998, Heterogeneous antibody responses in tuberculosis, Infect. Immun., 66, 3936, 10.1128/IAI.66.8.3936-3940.1998 Houghton, 2002, Use of multiepitope polyproteins in serodiagnosis of active tuberculosis, Clin. Diagn. Lab. Immunol., 9, 883 Weldingh, 2005, Assessing the serodiagnostic potential of 35 Mycobacterium tuberculosis proteins and identification of four novel serological antigens, J. Clin. Microbiol., 43, 57, 10.1128/JCM.43.1.57-65.2005 Lodes, 2001, Serological expression cloning and immunological evaluation of MTB48, a novel Mycobacterium tuberculosis antigen, J. Clin. Microbiol., 39, 2485, 10.1128/JCM.39.7.2485-2493.2001 Brusasca, 2001, Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome, Scand. J. Immunol, 54, 448, 10.1046/j.1365-3083.2001.00975.x Vordermeier, 2001, Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle, Clin. Diagn. Lab. Immunol., 8, 571, 10.1128/CDLI.8.3.571-578.2001 Cockle, 2002, Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics, Infect. Immun., 70, 6996, 10.1128/IAI.70.12.6996-7003.2002 He, 2003, Comparative proteome analysis of culture supernatant proteins of Mycobacterium tuberculosis H37Rv and H37Ra, Microbes Infect., 5, 851, 10.1016/S1286-4579(03)00179-5 Jungblut, 1999, Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens, Mol. Microbiol, 33, 1103, 10.1046/j.1365-2958.1999.01549.x Mattow, 2003, Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M. bovis BCG Copenhagen, Electrophoresis, 24, 3405, 10.1002/elps.200305601 Chakhaiyar, 2004, Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608, show a differential humoral response and a low T cell response in various categories of patients with tuberculosis, J. Infect. Dis., 190, 1237, 10.1086/423938 Choudhary, 2003, PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response, Infect. Immun., 71, 6338, 10.1128/IAI.71.11.6338-6343.2003 Delogu, 2001, Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis, Infect. Immun., 69, 5606, 10.1128/IAI.69.9.5606-5611.2001 Demangel, 2004, Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6, Infect. Immun., 72, 2170, 10.1128/IAI.72.4.2170-2176.2004 Okkels, 2003, PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family, Infect. Immun., 71, 6116, 10.1128/IAI.71.11.6116-6123.2003 Fleischmann, 2002, Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains, J. Bacteriol, 184, 5479, 10.1128/JB.184.19.5479-5490.2002 Cole, 1998, Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence, Nature, 393, 537, 10.1038/31159 Yuan, 1998, The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages, Proc. Natl. Acad. Sci. USA, 95, 9578, 10.1073/pnas.95.16.9578 Sherman, 2001, Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin, Proc. Natl. Acad. Sci. USA, 98, 7534, 10.1073/pnas.121172498 Boon, 2002, Mycobacterium bovis BCG response regulator essential for hypoxic dormancy, J. Bacteriol, 184, 6760, 10.1128/JB.184.24.6760-6767.2002 Andersen, 2005, The success and failure of BCG—implications for a novel tuberculosis vaccine, Nat. Rev. Microbiol, 3, 656, 10.1038/nrmicro1211 Launois, 1994, T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy, Infect. Immun., 62, 3679, 10.1128/IAI.62.9.3679-3687.1994 McShane, 2002, Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8+- and CD4+-T-cell epitopes from antigen 85A, Infect. Immun., 70, 1623, 10.1128/IAI.70.3.1623-1626.2002 Espitia, 1989, A 38-kD Mycobacterium tuberculosis antigen associated with infection. Its isolation and serologic evaluation, Clin. Exp. Immunol, 77, 373 Rosenkrands, 1999, Differential T-cell recognition of native and recombinant Mycobacterium tuberculosis GroES, Infect. Immun., 67, 5552, 10.1128/IAI.67.11.5552-5558.1999 Huygen, 1993, Influence of genes from the major histocompatibility complex on the antibody repertoire against culture filtrate antigens in mice infected with live Mycobacterium bovis BCG, Infect. Immun., 61, 2687, 10.1128/IAI.61.6.2687-2693.1993 Wheeler, 2006, Genome-wide scan for loci influencing quantitative immune response traits in the Belem family study: comparison of methods and summary of results, Ann. Hum. Genet., 70, 78, 10.1111/j.1529-8817.2005.00223.x Davidow, 2005, Antibody profiles characteristic of Mycobacterium tuberculosis infection state, Infect. Immun., 73, 6846, 10.1128/IAI.73.10.6846-6851.2005 Imaz, 2000, Antibody response to culture filtrate antigens of Mycobacterium tuberculosis during and after treatment of tuberculosis patients, Int. J. Tuberc. Lung Dis., 4, 562 Odorico, 2003, BEPITOPE: predicting the location of continuous epitopes and patterns in proteins, J. Mol. Recognit., 16, 20, 10.1002/jmr.602 Wilkinson, 2005, Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2, J. Immunol., 174, 4237, 10.4049/jimmunol.174.7.4237 Andersen, 1989, Structure and mapping of antigenic domains of protein antigen b, a 38,000-molecular-weight protein of Mycobacterium tuberculosis, Infect. Immun., 57, 2481, 10.1128/IAI.57.8.2481-2488.1989 De Smet, 2000, Three pathways for trehalose biosynthesis in mycobacteria, Microbiology, 146, 199, 10.1099/00221287-146-1-199 Ahmad, 2004, Mammalian cell-entry proteins encoded by the mce3 operon of Mycobacterium tuberculosis are expressed during natural infection in humans, Scand. J. Immunol, 60, 382, 10.1111/j.0300-9475.2004.01490.x Weldingh, 1998, Two-dimensional electrophoresis for analysis of Mycobacterium tuberculosis culture filtrate and purification and characterization of six novel proteins, Infect. Immun., 66, 3492, 10.1128/IAI.66.8.3492-3500.1998 Rosenkrands, 2000, Towards the proteome of Mycobacterium tuberculosis, Electrophoresis, 21, 3740, 10.1002/1522-2683(200011)21:17<3740::AID-ELPS3740>3.0.CO;2-3 Matsumoto, 1995, Cloning and sequencing of a unique antigen MPT70 from Mycobacterium tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle vector, Scand. J. Immunol, 41, 281, 10.1111/j.1365-3083.1995.tb03565.x Webb, 1998, Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis, Infect. Immun., 66, 4208, 10.1128/IAI.66.9.4208-4214.1998 Nagai, 1991, Isolation and partial characterization of major protein antigens in the culture fluid of Mycobacterium tuberculosis, Infect. Immun., 59, 372, 10.1128/IAI.59.1.372-382.1991 Turneer, 1988, Humoral immune response in human tuberculosis: immunoglobulins G, A, and M directed against the purified P32 protein antigen of Mycobacterium bovis bacillus Calmette-Guerin, J. Clin. Microbiol., 26, 1714, 10.1128/JCM.26.9.1714-1719.1988 Khan, 2008, Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis, Clin. Vaccine Immunol, 15, 433, 10.1128/CVI.00354-07 Johnson, 2001, Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis, Infect. Immun., 69, 5936, 10.1128/IAI.69.9.5936-5939.2001 Sanchez-Rodriguez, 2002, An IgG antibody response to the antigen 85 complex is associated with good outcome in Mexican Totonaca Indians with pulmonary tuberculosis, Int. J. Tuberc. Lung Dis., 6, 706