KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging Tập 4 Số 4 - Trang 259-263 - 2006
Zhang Zhang, Jun Li, Xiaoqian Zhao, Jun Wang, Gane Ka‐Shu Wong, Jun Yu
Abstract
KaKs_Calculator is a software package that calculates nonsynonymous (Ka) and synonymous (Ks) substitution rates through model selection and model averaging. Since existing methods for this estimation adopt their specific mutation (substitution) models that consider different evolutionary features, leading to diverse estimates, KaKs_Calculato...... hiện toàn bộ
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC) Tập 16 Số 3 - Trang 172-186 - 2018
Yajing Chu, Zhigang Zhao, David W. Sant, Ganqian Zhu, Sarah Greenblatt, Lin Liu, Jinhuan Wang, Zeng Cao, Jeanette Cheng Tho, Shi Chen, Xiaochen Liu, Peng Zhang, Jarosław P. Maciejewski, Stephen D. Nimer, Gaofeng Wang, Weiping Yuan, Feng‐Chun Yang, Mingjiang Xu
Abstract
As a dioxygenase, Ten-Eleven Translocation 2 (TET2) catalyzes subsequent steps of 5-methylcytosine (5mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation, and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential r...... hiện toàn bộ
A Stack-Based Ensemble Framework for Detecting Cancer MicroRNA Biomarkers Tập 15 Số 6 - Trang 381-388 - 2017
Sriparna Saha, Sayantan Mitra, Ravi Kant Yadav
Abstract
MicroRNA (miRNA) plays vital roles in biological processes like RNA splicing and regulation of gene expression. Studies have revealed that there might be possible links between oncogenesis and expression profiles of some miRNAs, due to their differential expression between normal and tumor tissues. However, the automatic classification of mi...... hiện toàn bộ
GranatumX: A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis Tập 19 - Trang 452-460 - 2021
David G. Garmire, Xun Zhu, Aravind Mantravadi, Qianhui Huang, Breck Yunits, Yu Liu, Thomas Wolfgruber, Olivier Poirion, Tianying Zhao, Cédric Arisdakessian, Stefan Stanojevic, Lana X. Garmire
Identification of Age-associated Proteins and Functional Alterations in Human Retinal Pigment Epithelium Tập 20 - Trang 633-647 - 2022
Xiuxiu Jin, Jingyang Liu, Weiping Wang, Jiangfeng Li, Guangming Liu, Ruiqi Qiu, Mingzhu Yang, Meng Liu, Lin Yang, Xiaofeng Du, Bo Lei