Scopolamine into the anterior cingulate cortex diminishes nociception in a neuropathic pain model in the rat: an interruption of ‘nociception‐related memory acquisition’?

European Journal of Pain - Tập 7 Số 5 - Trang 425-429 - 2003
J. Manuel Ortega‐Legaspi1, Alberto López-Ávila2, Ulises Coffeen2, Rosendo del Ángel2, Francisco Pellicer2
1Facultad de Medicina, Núcleos de Calidad Educativa, Universidad Nacional Autónoma de México, México D.F.
2Subdirección de Neurociencias, Instituto Nacional de Psiquiatría, Ramón de la Fuente, Camino a Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México

Tóm tắt

AbstractThe cingulate cortex plays a key role in the affective component related to pain perception. This structure receives cholinergic projections and also plays a role in memory processing. Therefore, we propose that the cholinergic system in the anterior cingulate cortex is involved in the nociceptive memory process. We used scopolamine ( in ) microinjected into the anterior cingulate cortex, either before thermonociception followed by a sciatic denervation, between thermonociception and denervation or after both procedures (n=10 each). The vehicle group (saline solution 0.9%, n=14) was microinjected before thermonociception. Chronic nociception was measured by the autotomy score, which onset and incidence were also determined. Group scopolamine—thermonociception–denervation (STD) presented the lowest autotomy score as compared to vehicle and group thermonociception—denervation–scopolamine (TDS) (vehicle vs. STD, p=0.002, STD vs. TDS, p=0.001). Group thermonociception‐scopolamine‐denervation (TSD) showed a diminished autotomy score when compared to TDS (p=0.053). STD group showed a delay in the onset of AB as compared to the rest of the groups. Group TSD presented a significative delay (p=0.048) in AB onset when compared to group TDS. There were no differences in the incidence between groups. The results show that nociception‐related memory processed in the anterior cingulate cortex is susceptible of being modified by the cholinergic transmission blockade. When scopolamine is microinjected prior to the nociceptive stimuli, nociception‐related memory acquisition is prevented. The evidence obtained in this study shows the role of the anterior cingulate cortex in the acquisition of nociception‐related memory.

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European Journal of Pain

Tập 7 Số 5

425-429

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