Scalp cooling for hair loss prevention in female Japanese breast cancer patients receiving (neo)adjuvant chemotherapy

Springer Science and Business Media LLC - Tập 29 - Trang 437-443 - 2020
Shozo Ohsumi1, Sachiko Kiyoto1, Mina Takahashi1, Fumikata Hara2, Seiki Takashima1, Kenjiro Aogi1, Miwa Matsuda1, Naomi Yamamura1, Miyuki Doi1
1Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
2Department of Breast Medical Oncology, Breast Oncology Center, Cancer Institute Hospital for JFCR, Tokyo, Japan

Tóm tắt

Scalp cooling during chemotherapy infusion has been recently reported to have moderate efficacy in the mitigation of chemotherapy-induced alopecia; however, there are few reports on Asian patients. We aimed to clarify the effects of scalp cooling in Japanese women. Female Japanese breast cancer patients who planned to receive (neo)adjuvant chemotherapy participated in this prospective study on the efficacy of scalp cooling using the Paxman Scalp Cooling System for alopecia prevention. The primary outcomes were the rates of patients with Grade 3 alopecia (defined as hair loss of > 50%) and the rates of patients who used a wig or hat to conceal hair loss 1 month after the last infusion of chemotherapy. The subjects were given a brief questionnaire regarding headaches, bad mood, fatigue, and chills shortly after each cooling. One hundred and forty-three patients participated in the study and used the cooling cap at least once. The mean and median ages of the subjects were 50.6 and 50, respectively (age range 28–76). One hundred and twenty-nine patients completed the planned chemotherapy of 4 to 8 cycles. Among them (7 patients were not evaluable), 74 patients (60.7%) had Grade 3 alopecia 1 month after chemotherapy. Of 80 patients who used the scalp cooling system throughout the planned chemotherapy (1 patient was not evaluable), 36 patients (45.6%) experienced Grade 3 alopecia. The efficacy of scalp cooling during chemotherapy infusion for hair loss mitigation in Asian women is similar to that in Caucasian women.

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Springer Science and Business Media LLC

Tập 29

437-443

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