Salience network and parahippocampal dopamine dysfunction in memory‐impaired Parkinson disease

Annals of Neurology - Tập 77 Số 2 - Trang 269-280 - 2015
Leigh Christopher1,2,3, Sarah Duff‐Canning2, Yuko Koshimori1,2,3, Bàrbara Segura4,1,3, Isabelle Boileau3, Robert Chen2, Anthony E. Lang2, Sylvain Houle3, Pablo Rusjan3, Antonio P. Strafella1,2,3
1Division of Brain, Imaging, and Behaviour–Systems Neuroscience Toronto Western Research Institute, University Health Network, University of Toronto Toronto Ontario Canada
2Morton and Gloria Shulman Movement Disorder Unit and Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
3Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
4Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain

Tóm tắt

ObjectivePatients with Parkinson disease (PD) and mild cognitive impairment (MCI) are vulnerable to dementia and frequently experience memory deficits. This could be the result of dopamine dysfunction in corticostriatal networks (salience, central executive networks, and striatum) and/or the medial temporal lobe. Our aim was to investigate whether dopamine dysfunction in these regions contributes to memory impairment in PD.MethodsWe used positron emission tomography imaging to compare D2 receptor availability in the cortex and striatal (limbic and associative) dopamine neuron integrity in 4 groups: memory‐impaired PD (amnestic MCI; n = 9), PD with nonamnestic MCI (n = 10), PD without MCI (n = 11), and healthy controls (n = 14). Subjects were administered a full neuropsychological test battery for cognitive performance.ResultsMemory‐impaired patients demonstrated more significant reductions in D2 receptor binding in the salience network (insular cortex and anterior cingulate cortex [ACC] and the right parahippocampal gyrus [PHG]) compared to healthy controls and patients with no MCI. They also presented reductions in the right insula and right ACC compared to nonamnestic MCI patients. D2 levels were correlated with memory performance in the right PHG and left insula of amnestic patients and with executive performance in the bilateral insula and left ACC of all MCI patients. Associative striatal dopamine denervation was significant in all PD patients.InterpretationDopaminergic differences in the salience network and the medial temporal lobe contribute to memory impairment in PD. Furthermore, these findings indicate the vulnerability of the salience network in PD and its potential role in memory and executive dysfunction. Ann Neurol 2015;77:269–280

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Annals of Neurology

Tập 77 Số 2

269-280

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