Saffron for treatment of fluoxetine‐induced sexual dysfunction in women: randomized double‐blind placebo‐controlled study

Human Psychopharmacology - Tập 28 Số 1 - Trang 54-60 - 2013
Ladan Kashani1, Firoozeh Raisi2, Sepideh Saroukhani2, Hamid R. Sohrabi2, Amirhossein Modabbernia2, Abbas Ali Nasehi2, A H Jamshidi2, Mandana Ashrafi2, Parisa Mansoori2, Padideh Ghaeli2, Shahin Akhondzadeh2
1Infertility Ward, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

Tóm tắt

ObjectiveSaffron (Crocus sativus L.) has shown beneficial aphrodisiac effects in some animal and human studies. The aim of the present study was to assess the safety and efficacy of saffron on selective serotonin reuptake inhibitor‐induced sexual dysfunction in women.MethodsThis was a randomized double‐blind placebo‐controlled study. Thirty‐eight women with major depression who were stabilized on fluoxetine 40 mg/day for a minimum of 6 weeks and had experienced subjective feeling of sexual dysfunction entered the study. The patients were randomly assigned to saffron (30 mg/daily) or placebo for 4 weeks. Measurement was performed at baseline, week 2, and week 4 using the Female Sexual Function Index (FSFI). Side effects were systematically recorded.ResultsThirty‐four women had at least one post‐baseline measurement and completed the study. Two‐factor repeated measure analysis of variance showed significant effect of time × treatment interaction [Greenhouse–Geisser's corrected: F(1.580, 50.567) = 5.366, p = 0.012] and treatment for FSFI total score [F(1, 32) = 4.243, p = 0.048]. At the end of the fourth week, patients in the saffron group had experienced significantly more improvement in total FSFI (p < 0.001), arousal (p = 0.028), lubrication (p = 0.035), and pain (p = 0.016) domains of FSFI but not in desire (p = 0.196), satisfaction (p = 0.206), and orgasm (p = 0.354) domains. Frequency of side effects was similar between the two groups.ConclusionsIt seems saffron may safely and effectively improve some of the fluoxetine‐induced sexual problems including arousal, lubrication, and pain. Copyright © 2012 John Wiley & Sons, Ltd.

Từ khóa


Tài liệu tham khảo

10.1111/j.1471-0528.2007.01652.x

10.1097/00002826-199508000-00003

10.1016/j.pnpbp.2006.11.010

10.1186/1472-6882-4-12

10.1002/ptr.1647

10.1111/j.1365-2710.2009.01133.x

10.1007/s00213-009-1706-1

Balon R, 1993, Fluoxetine‐induced sexual dysfunction and yohimbine, J Clin Psychiatry, 54, 161

10.4088/JCP.v62n0309

Feder R, 1991, Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients, J Clin Psychiatry, 52, 163

10.1002/(SICI)1520-6394(1999)9:4<180::AID-DA6>3.0.CO;2-#

10.1080/00926230252851267

10.1002/ptr.3011

Hosseinzadeh H, 2005, Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus, J Pharm Pharm Sci, 8, 394

10.1089/dna.2007.0631

10.1186/1471-2210-2-7

10.1016/j.phymed.2007.09.020

10.1093/ecam/nem125

10.1002/ptr.3566

10.1097/00004714-199906000-00012

10.1177/026988119701100117

10.1007/s00213-012-2729-6

10.1002/hup.1243

10.1080/00926239708403923

10.1016/j.jmwh.2008.12.006

10.1016/j.jep.2004.11.004

10.1080/009262300278597

10.1097/JCP.0b013e3181a5233f

10.1016/j.phymed.2009.03.008

10.3109/13651501.2011.617457

10.1111/j.1743-6109.2008.01150.x

10.1345/aph.17428

Thông tin
Thông tin xuất bản

Human Psychopharmacology

Tập 28 Số 1

54-60

Thông tin tác giả