SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

The acetohydrazides A5 containing an isoxazole ring and B5 containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones B6 and B7 were driven from acetohydrazide B4 by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones  B7 showing moderate reactivity against KB cancer cell line at IC50 = 57 mg/L.