SUMO: regulating the regulator

Springer Science and Business Media LLC - Tập 1 - Trang 1-8 - 2006
Guillaume Bossis1,2, Frauke Melchior2
1Institut de Génétique Moléculaire de Montpellier, CNRS, Montpellier Cedex 05, France
2Dept. of Biochemie I, University Goettingen, Goettingen, Germany

Tóm tắt

Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review will provide an overview on recent advances concerning (i) the interplay between sumoylation and other post-translational modifications at the level of individual targets and (ii) global regulation of SUMO conjugation and deconjugation.

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