Role of the modulation of CYP1A1 expression and activity in chemoprevention
Tóm tắt
As one of the main extra‐hepatic cytochrome P450 (CYP) enzymes, CYP1A1 has been comprehensively investigated for its ability to metabolize both exogenous and endogenous compounds into their carcinogenic derivatives. These derivatives are linked to cancer initiation and progression. The compound benzo‐a‐pyrene (BaP), a copious and noxious compound present in coal tar, automobile exhaust fumes, cigarette smoke and charbroiled food, is metabolised by CYP1A1 and has been studied in great detail. Other compounds reliant on the same enzyme for their activation include 7,12 dimethylbenz(a)anthracene (DMBA) and heterocyclic amine, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP). This review takes an in‐depth look at a number of phytochemicals, plant extracts and a few synthetic compounds that have been researched and deemed potential chemopreventives via their interaction with the activity and expression of CYP1A1. It will also review a useful active site model of CYP1A1. Based on inhibitors of CYP1A1 that have demonstrated
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Tài liệu tham khảo
Androutsopoulos V, 2009, Cytochrome P450 Cyp1a1: Wider Roles in Cancer Progression and Prevention, Biomed. Central Cancer, 9, 187
Bourrié M, 1996, Cytochrome P450 Isoform Inhibitors as a Tool for the Investigation of Metabolic Reactions Catalyzed by Human Liver Microsomes, JPET, 277, 321
Buterin T, 2000, Unrepaired Fjord Region Polycyclic Aromatic Hydrocarbon‐DNA Adducts in Ras Codon 61 Mutational Hot Spots, Cancer Res., 60, 1849
Callero M, 2012, Aryl Hydrocarbon Receptor Activation by Aminoflavone: New Molecular Target for Renal Cancer Treatment, Int. J. Oncol., 41, 125
Chabner B, 1991, Anti‐Cancer Drugs, Principles and Practice
Chabner B, 1996, The Pharmacological Basis of Therapeutics, 1233
Ciolino H, 1998, Resveratrol Inhibits Transcription of Cyp1a1 in Vitro by Preventing Activation of the Aryl Hydrocarbon Receptor, Cancer Res., 58, 5707
Coon M, 1996, Peroxidative Reactions of Diversozymes, FASEB J., 10, 428, 10.1096/fasebj.10.4.8647341
Easton D, 1995, Breast and Ovarian Cancer Incidence in Brca1‐Mutation Carriers, Am. J. Hum. Genet., 56, 265
Hakkak R, 2000, Diets Containing Whey Proteins or Soy Protein Isolate Protect against 7,12‐Dimethylbenz(a)Anthracene‐Induced Mammary Tumors in Female Rats, Cancer Epidemiol. Biomarkers Prev., 9, 113
Hamid A, 2011, Recent Role of Inflammation in Prostate Diseases: Chemoprevention Development Opportunity, Acta Med. Indones‐Indones J. Intern. Med., 43, 59
IARC.2010.Agents Classified by the Iarc Monographs2010 [cited 1–100]. http://monographs.iarc.fr/ENG/Classification/ClassificationsAlphaOrder.pdf.
Klassenn D, 2001, Casarette and Doull's Toxicology: The Basic Science of Poisons, 107
MacDonald C, 2001, Dibenzoylmethane Modulates Aryl Hydrocardon Receptor Function and Expression of Cytochromes P450 1a1, 1a2 and 1b1, Cancer Res., 61, 3919
Rinaldi A, 2002, Curcumin Activates the Aryl Hydrocarbon Receptor yet Significantly Inhibits (‐)‐Benzo(a)Pyrene‐7r‐Trans‐7,8‐Dihydrodiol Bioactivation in Oral Squamous Cell Carcinoma Cells and Oral Mucosa, Cancer Res., 62, 5451
Schwarz D, 2003, St. John's Wort Extracts and Some of Their Constituents Potently Inhibit Ultimate Carcinogen Formation from Benzo[a]Pyrene‐7,8‐Dihydrodiol by Human Cyp1a1, Cancer Res., 15, 8062
Shimada T, 1989, Roles of Individual Human Cytochrome P‐450 Enzymes in the Bioactivation of Benzo[a]Pyrene, 7,8‐Dihydroxy‐7,8‐Dihydrobenzo[a]Pyrene. And Other Dihydrodiol Derivatives of Polycyclic Aromatic Hydrocarbons, Cancer Res., 49, 6304
Treasure J, 2000, Herbal Pharmacokinetics: A Practitioner Update with Reference to St. Johns Wort (Hypericum Perforatum) Herb‐Drug Interactions, MNIMH, 1, 6
Wei O, 1996, Benzo (a) Pyrene Diol Epoxide‐Induced Chromosomal Aberrations and Risk of Lung Cancer, Cancer Res., 56, 3975
WHO, 2013, Cancer
Yarbro J, 1992, The Scientific Basis of Cancer Chemotherapy, The Chemotherapy Source Book