Role of plasma membrane defect of skeletal muscle in malignant hyperthermia

Muscle and Nerve - Tập 2 Số 6 - Trang 491-494 - 1979
Esther M. Gallant1, Robert E. Godt2, Gerald A. Gronert3
1Departments of Pharmacology, Mayo Foundation, Rochester, MN
2Department of Physiology, Medical College of Georgia, Augusta, Ga
3Departments of Anesthesiology, Mayo Foundation, Rochester, MN

Tóm tắt

AbstractHalothane, at clinical concentrations, depolarizes the plasma membrane of skeletal muscle from Poland China pigs susceptible to malignant hyperthermia but does not affect the resting membrane potential of muscle from normal Poland China pigs, mice, or frogs. The depolarization is reduced or partially reversed in the presence of dantrolene sodium. We suggest the possibility that malignant hyperthermia may be initiated by this abnormal depolarization of skeletal muscle by halothane.

Từ khóa


Tài liệu tham khảo

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