Role of interleukin-6 in ischemic stroke outcome

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery - Tập 56 Số 1 - 2020
Hany Aref1, Nagia Fahmy1, Salma Khalil1, Mai Fathy Ahmed1, Ahmed ElSadek1, Mohamed Osama Abdulghani1
1Ain Shams University, El Rehab, Cairo, Egypt

Tóm tắt

Abstract Background High levels of inflammatory markers such as C-reactive protein (CRP) and interleukin (IL)-6 are associated with worse outcome after ischemic stroke. Objectives To study whether the level of IL-6 following ischemic stroke is related to the severity of stroke, infarct volume, stroke subtype, and its impact on stroke outcome. Materials and methods A total of 90 patients of acute ischemic stroke were enrolled with calculation of infarct volume in MRI brain, and serum IL-6 samples were obtained within 24 h and also after 3 months from stroke onset. NIHSS and MRS were done at stroke onset and after 3 months. Results The mean value of IL-6 was higher among patients with small vessel occlusion (8.47 pg/ml) with a significant positive correlation between IL-6 and National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (MRS) after 3 months. IL-6 was significantly higher in patients with recurrence with a cutoff IL-6 value above which recurrence is anticipated which is 7.75 pg/ml. Conclusion Our study concluded that inflammation has an important role in the pathogenesis of acute ischemic stroke particularly small vessel occlusion and it provided evidence that IL-6 contributes to the determination of clinical outcome of acute ischemic stroke and prediction of recurrence.

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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Tập 56 Số 1

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