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Supported by Deutsche Forschungsgemeinschaft grant SO366/1-3. We are grateful to L. Y. Kwok K. Schönig and A. Herm-Götzfor their assistance and S. Brecht and C. Hettmann for their contributions to the early phase of the project. Special thanks to T. Soldati for his assistance with the microscopy and considerable input in the project H. Bujard for helpful discussions and R. Sindenfor critical reading of the manuscript.