Role of biomarkers in studies of presymptomatic Alzheimer's disease

Alzheimer's & Dementia - Tập 1 - Trang 145-151 - 2005
John C. Morris1, A. Kimberly1,2,3,4,5,6,7, K. Quaid2, David M. Holtzman1, Kejal Kantarci3, Jeffrey Kaye4, Eric M. Reiman5, William E. Klunk6, Eric R. Siemers7
1Washington University in St. Louis, School of Medicine, Department of Neurology, Alzheimer’s Disease Research Center, MO USA
2Indiana University School of Medicine, Center for Bioethics, IN USA
3Mayo Clinic, Alzheimer’s Disease Research Center, Rochester, MN USA
4Layton Aging & Alzheimer’s Disease Center, Oregon Health and Sciences University, Portland, OR USA
5Banner Good Samaritan Medical Center, University of Arizona, Translational Genomics Research Institute, Arizona Alzheimer’s Disease Consortium, Phoenix, AZ USA
6University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Laboratory of Molecular Neuropharmacology, Department of Psychiatry, PA USA
7Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN USA

Tóm tắt

Background

Biomarkers that have been developed largely for the study of patients with clinically diagnosed Alzheimer's disease (AD) can also be used in the study of cognitively normal individuals who may harbor underlying AD pathology.

Methods

A meeting of invited experts on AD biomarkers was held on November 11 and 12, 2004 to review currently available data and to discuss unmet needs for biomarker research in presymptomatic AD.

Results

Neuroimaging biomarkers have been studied to some extent in subjects at risk for AD. These imaging techniques include volumetric magnetic resonance imaging and positron emission tomography using either fluorodeoxyglucose or newer ligands that bind directly to amyloid plaque. Similarly, biochemical measures from cerebrospinal fluid or other physiologic fluids are emerging as potentially useful tools. Such biomarkers may be used either as diagnostic tools or as indicators of disease severity when followed longitudinally. A clinical diagnosis of asymptomatic individuals using biomarkers and studies involving asymptomatic subjects may raise logistical and ethical concerns.

Conclusions

The technical development of biomarkers that are used for presymptomatic AD diagnosis and for longitudinally measuring disease severity is evolving rapidly. Ethical and privacy considerations must be made before such biomarkers can be applied routinely to asymptomatic populations.


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