Role of T Lymphocytes in Experimental Staphylococcus aureus Arthritis

Scandinavian Journal of Immunology - Tập 39 Số 4 - Trang 403-408 - 1994
Arturo Abdelnour1, T Bremell1,2, Rikard Holmdahl3, Andrzej Tarkowski1,2
1Department of Clinical Immunology, University of Cöteborg, Sweden
2Department of Rheumatology, University of Cöteborg, Sweden
3Depratment of Medical and Physiological Chemistry, Biomedical Center, University of Uppsala, Sweden

Tóm tắt

Using a recently developed murine model of haematogenously induced Staphylococcus aureus, the authors have characterized the phenotypes and functional properties of inflammatory cells present in the synovium of arthritic mice. The results show that large numbers of granulocytes and macrophages were observed in the inflamed synovia within 24 h of inoculation of S. aureus strain LS‐1. Many of the synovial macrophage‐like cells stained for cytoplasmic IL‐1α and TN F‐α. Subsequently (< 48 h later), a prominent infiltration of T lymphocytes, predominantly of CD4+ phenotype, was observed. Some of the T lymphocytes stained for IL‐2 receptor and intracytoplasmicinterferon‐γ (IFN‐γ). Surprisingly, in spite of the severe inflammatory process, very few cells expressed MHC class‐II molecules in the arthritic synovia. In addition, in vivo depletion of CD4 + T‐cells resulted in a considerably milder course of staphylococcal arthritis. The similarities in the phenotype expression of synovial cells and central role of T‐cells in S. aureus arthritis as well as in non‐infectious models of arthritis, indicate that the process governing joint destruction is likely to be the same, irrespective of the initial stimulus.

Từ khóa


Tài liệu tham khảo

10.1056/NEJM198503213121206

10.1002/anr.1780320422

Mahowald M, 1986, Animal models of infectious arthritis, Clin Rheum Dis, 12, 403, 10.1016/S0307-742X(21)00558-0

Bremell T, 1991, Experimental Staphylococcus aureus arthitis in mice, Infect Immun, 59, 2615, 10.1128/iai.59.8.2615-2623.1991

Bremell T, 1992, Histopathological and serological progression of experimental Staphlococcus aureus arthitis, Infect Immun, 60, 2976, 10.1128/iai.60.7.2976-2985.1992

10.1016/0022-1759(86)90058-X

10.1002/art.1780331120

Goldschmidt T, 1990, In vivo elimination of T‐cells expressing specific T‐cell receptor Vβ chains in mice susceptible to collagen‐induced arthritis, Immunology, 69, 508

10.1016/0022-1759(88)90130-5

10.1002/art.1780290314

10.1177/29.4.6166661

10.1093/ajcp/63.3.451

10.1002/art.1780300110

10.1073/pnas.72.3.1059

Fernandez H, 1978, Chemoatactic response to human C3a and C5a anaphylatoxins I. Evaluation of C3a and 5a leukotaxis in vitro and under stimulated in vivo conditions, J Immunol, 120, 109, 10.4049/jimmunol.120.1.109

10.1093/infdis/154.1.55

Bates E, 1991, Characterization of the major neutrophil‐stimulating activity present in culture medium conditioned by Staphylococcus aureus‐stimulated mononuclear leucocytes, Immunology, 72, 448

Rieckmann P, 1991, IL‐6 and tumor necrosis factor‐α: autocrine and paracrine cytokines involved in B cell function, J Immunol, 146, 3462, 10.4049/jimmunol.146.10.3462

10.1056/NEJM198710083171506

10.1093/infdis/163.6.1177

10.1038/346425a0

Cheung A, 1991, Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells, Infect Immun, 59, 3827, 10.1128/iai.59.10.3827-3831.1991

10.1002/art.1780330302

10.1093/infdis/163.6.1267

10.1126/science.2185544

10.1016/S0167-5699(05)80043-X

Klareskog L, 1983, Rob of T lymphocytes in collagen II induced arthritis in rats, Clin Exp Immunol, 51, 117

Quinn DeJoy S, 1989, Streptococcal cell wall arthritis, J Exp Med, 170, 369

Larsson P, 1985, In vivo treatment with W 3/13 (anti‐pan T) but not with OX 8 (anti‐suppressor/cytotoxic T) monoclonal antibodies impedes the development of adjuvant arthritis in rats, Immunology, 56, 383

10.1002/eji.1830090410

Ho M, 1982, Mac‐2, a novel 32, 000 Mr mouse macrophage subpopulation specific antigen defined by mononclonal antibodies, J Immunol, 128, 1221, 10.4049/jimmunol.128.3.1221

Dialynas D, 1983, Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal GK 1.5: similarity of L3T4 to the human Leu‐3/T4 molecule, J Immunol, 131, 2445, 10.4049/jimmunol.131.5.2445

10.1111/j.1600-065X.1979.tb00289.x

10.1111/j.1600-065X.1979.tb00291.x

10.1073/pnas.80.18.5694

10.1099/0022-1317-67-6-1059

Thông tin
Thông tin xuất bản

Scandinavian Journal of Immunology

Tập 39 Số 4

403-408

Thông tin tác giả