Role of Increased Cerebral myo‐Inositol in the Dementia of Down Syndrome

Magnetic Resonance in Medicine - Tập 33 Số 6 - Trang 858-861 - 1995
Truda Shonk1,2, Brian D. Ross1,3,2
1California Institute of Technology, Pasadena, California
2Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes
3Department of Chemistry and Chemical Engineering

Tóm tắt

Abstract

The purpose of this study was to determine cerebral myo‐inositol (ml) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD). AD has characteristic neuropathology of neurofibrillary plaques and tangles; indirect evidence links this to earlier deposition of β‐amyloid. Elevated ml, which distinguishes AD from other common dementias, is also elevated in 23 young patients who have DS without dementia. In one patient who has DS with dementia, ml is elevated and N‐acetylaspartate (NAA) decreased. The similarity to AD is striking and may suggest a progressive neurochemical disorder in which elevation of ml precede loss of NAA in both AD and DS.

Từ khóa


Tài liệu tham khảo

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Thông tin xuất bản

Magnetic Resonance in Medicine

Tập 33 Số 6

858-861

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