Role of Contrast Echocardiography for the Assessment of Left Ventricular Function

Echocardiography - Tập 16 Số s1 - Trang 747-752 - 1999
Roxy Senior1
1Department of Cardiovascular Medicine, Northwick Park Hospital and Institute for Medical Research, Harrow, United Kingdom

Tóm tắt

The endocardial border of the left ventricle is incompletely identified in at least 30% of patients at rest or during stress echocardiography during fundamental imaging. This may lead to inaccurate assessment of regional and global left ventricular function or may lead to further diagnostic imaging with another modality resulting in a higher cost of healthcare. The recent development of second generation ultrasound contrast agents has resulted in improved detection of endocardial border at rest and during stress fundamental echocardiography. This has been consistently shown in various clinical trials involving 702 patients using a new contrast agent, SonoVue™. Other studies with contrast agents have also shown improved accuracy for determining left ventricular ejection fraction and volumes. Although unenhanced tissue harmonic imaging itself improved the assessment of left ventricular function, contrast enhanced harmonic imaging has recently been shown to be more accurate; however, larger clinical studies are required to establish the value of harmonic contrast imaging for the assessment of left ventricular function.

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Tài liệu tham khảo

10.1016/0002-9149(88)91148-4

10.1161/01.CIR.96.9.2932

10.1016/S0002-8703(98)70078-X

10.1161/01.CIR.76.1.44

10.1016/0002-9149(74)90093-9

10.1161/01.CIR.59.5.926

10.1016/S0894-7317(89)80006-9

10.1016/0735-1097(94)90107-4

Senior R, 1994, Comparison of radionuclide ventriculography and 2D echocardiography for the measurement of left ventricular ejection fraction following acute myocardial infarction, Eur Heart J, 15, 1235, 10.1093/oxfordjournals.eurheartj.a060658

10.1016/0735-1097(95)00483-1

10.1121/1.417977

10.1109/58.585208

10.1121/1.1918142

10.1016/S0002-8703(99)70263-2

Caidahl K, 1997, Harmonic imaging improves the echocardiographic signal to noise ratio without use of a contrast agent, Eur Heart J, 19, 146

10.1016/S0140-6736(98)02361-7

Pyles JM, 1998, Enhanced endocardial visualization using harmonic imaging without contrast, Cardiovasc Imaging, 10, 77

10.1121/1.413795

10.1161/01.CIR.67.3.585

10.1016/0735-1097(93)90562-F

Senior R, 1998, and the European Trial Investigators: Enhanced endocardial visualisation with a new contrast agent BR‐1 compared to routine two‐dimensional echocardiography: A European multicentre study, Eur Heart J, 19, P2354

10.1016/0735-1097(94)90389-1

10.1016/S0894-7317(96)90098-X

10.1016/S0735-1097(98)00409-4

Al‐Mansour HA, 1998, Is harmonic contrast echocardiography the procedure of choice for optimal endocardial border definition, J Am Soc Echo Cardiogr, 11, 527

10.1016/S0002-9149(97)00217-8

Sandelski J, 1998, Improved quantification of left ventricular ejection fraction using Optison, J Am Soc Echo Cardiogr, 11, 554

Mulvagh SL, 1998, Harmonic dobutamine stress echocardiography: Does contrast make a difference in diagnostic feasibility and accuracy, Circulation, 12, 527