Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

American Association for the Advancement of Science (AAAS) - Tập 257 Số 5067 - Trang 212-214 - 1992
Yufang Shi1, J M Glynn2, Lawrence J. Guilbert1, Thomas G. Cotter2, Reid P. Bissonnette3, Douglas R. Green3
1Department of Immunology, University of Alberta, Edmonton, Canada T6G 2H7.
2Department of Biology St. Patrick's College, Maynooth, County Kildare Ireland R.
3La Jolla Institute for Allery and Immunology, La Jolla, CA 92037.

Tóm tắt

Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells, although none of the genes required for this process have previously been identified. Antisense oligonucleotides corresponding to c- myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells. These data indicate that c- myc expression is a necessary component of activation-induced apoptosis.

Từ khóa


Tài liệu tham khảo

10.1016/S0065-2776(08)60756-7

ASKEW, D.S., CONSTITUTIVE C-MYC EXPRESSION IN AN IL-3-DEPENDENT MYELOID CELL-LINE SUPPRESSES CELL-CYCLE ARREST AND ACCELERATES APOPTOSIS, ONCOGENE 6: 1915 (1991).

10.1126/science.2251503

BURSCH, W, BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 68: 1071 (1990).

COHEN, J.J., GLUCOCORTICOID ACTIVATION OF A CALCIUM-DEPENDENT ENDONUCLEASE IN THYMOCYTE NUCLEI LEADS TO CELL-DEATH, JOURNAL OF IMMUNOLOGY 132: 38 (1984).

COLE, M.D., THE MYC ONCOGENE - ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION, ANNUAL REVIEW OF GENETICS 20: 361 (1986).

COTTER, T.G., MICROFILAMENT-DISRUPTING AGENTS PREVENT THE FORMATION OF APOPTOTIC BODIES IN TUMOR-CELLS UNDERGOING APOPTOSIS, CANCER RESEARCH 52: 997 (1992).

DEGOLS, G, ANTIPROLIFERATIVE EFFECTS OF ANTISENSE OLIGONUCLEOTIDES DIRECTED TO THE RNA OF C-MYC ONCOGENE, NUCLEIC ACIDS RESEARCH 19: 945 (1991).

DUKE, R.C., IL-2 ADDICTION - WITHDRAWAL OF GROWTH-FACTOR ACTIVATES A SUICIDE PROGRAM IN DEPENDENT T-CELLS, LYMPHOKINE RESEARCH 5: 289 (1986).

EVAN, G.I., INDUCTION OF APOPTOSIS IN FIBROBLASTS BY C-MYC PROTEIN, CELL 69: 119 (1992).

FESUS, L, INDUCTION AND ACTIVATION OF TISSUE TRANSGLUTAMINASE DURING PROGRAMMED CELL-DEATH, FEBS LETTERS 224: 104 (1987).

FOTEDAR, A, FINE SPECIFICITY OF ANTIGEN RECOGNITION BY T-CELL HYBRIDOMA CLONES SPECIFIC FOR POLY-18 - A SYNTHETIC POLYPEPTIDE ANTIGEN OF DEFINED SEQUENCE AND CONFORMATION, JOURNAL OF IMMUNOLOGY 135: 3028 (1985).

HARELBELLAN, A, SPECIFIC-INHIBITION OF C-MYC PROTEIN-BIOSYNTHESIS USING AN ANTISENSE SYNTHETIC DEOXY-OLIGONUCLEOTIDE IN HUMAN LYMPHOCYTES-T, JOURNAL OF IMMUNOLOGY 140: 2431 (1988).

HEIKKILA, R, A C-MYC ANTISENSE OLIGODEOXYNUCLEOTIDE INHIBITS ENTRY INTO S-PHASE BUT NOT PROGRESS FROM G0 TO G1, NATURE 328: 445 (1987).

HOLT, J.T., AN OLIGOMER COMPLEMENTARY TO C-MYC MESSENGER-RNA INHIBITS PROLIFERATION OF HL-60 PROMYELOCYTIC CELLS AND INDUCES DIFFERENTIATION, MOLECULAR AND CELLULAR BIOLOGY 8: 963 (1988).

IWATA, M, RESCUE OF THYMOCYTES AND T-CELL HYBRIDOMAS FROM GLUCOCORTICOID-INDUCED APOPTOSIS BY STIMULATION VIA THE T-CELL RECEPTOR CD3 COMPLEX - A POSSIBLE INVITRO MODEL FOR POSITIVE SELECTION OF THE T-CELL REPERTOIRE, EUROPEAN JOURNAL OF IMMUNOLOGY 21: 643 (1991).

KADDURAHDAOUK, R, ACTIVATION AND REPRESSION OF MAMMALIAN GENE-EXPRESSION BY THE C-MYC PROTEIN, GENES & DEVELOPMENT 1: 347 (1987).

10.1016/0092-8674(87)90568-X

10.1016/S0074-7696(08)62312-8

Kerr, J. F. R., Perspectives in Mammalian Cell Death: 93 (1987).

MCCONKEY, D.J., RAPID TURNOVER OF ENDOGENOUS ENDONUCLEASE ACTIVITY IN THYMOCYTES - EFFECTS OF INHIBITORS OF MACROMOLECULAR-SYNTHESIS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 278: 284 (1990).

MCMANAWAY, M.E., TUMOR-SPECIFIC INHIBITION OF LYMPHOMA GROWTH BY AN ANTISENSE OLIGODEOXYNUCLEOTIDE, LANCET 335: 808 (1990).

MORRIS, R.G., HORMONE-INDUCED CELL-DEATH .2. SURFACE CHANGES IN THYMOCYTES UNDERGOING APOPTOSIS, AMERICAN JOURNAL OF PATHOLOGY 115: 426 (1984).

ODAKA, C, T-CELL RECEPTOR-MEDIATED DNA FRAGMENTATION AND CELL-DEATH IN T-CELL HYBRIDOMAS, JOURNAL OF IMMUNOLOGY 144: 2096 (1990).

OWENS, G.P., IDENTIFICATION OF MESSENGER-RNAS ASSOCIATED WITH PROGRAMMED CELL-DEATH IN IMMATURE THYMOCYTES, MOLECULAR AND CELLULAR BIOLOGY 11: 4177 (1991).

PALLAVICINI, M.G., RELATIONSHIP OF C-MYC GENE COPY NUMBER AND GENE-EXPRESSION - CELLULAR EFFECTS OF ELEVATED C-MYC PROTEIN, JOURNAL OF CELLULAR PHYSIOLOGY 143: 372 (1990).

PENDERGAST, G.C., CELL 65: 395 (1991).

PULLEN, A.M., TOLERANCE TO SELF ANTIGENS SHAPES THE T-CELL REPERTOIRE, IMMUNOLOGICAL REVIEWS 107: 125 (1989).

REED, J.C., BCL2-MEDIATED TUMORIGENICITY OF A HUMAN T-LYMPHOID CELL-LINE - SYNERGY WITH MYC AND INHIBITION BY BCL2 ANTISENSE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 3660 (1990).

REIGEL, J.S., J IMMUNOL 144: 3611 (1990).

10.1038/352541a0

10.1038/343170a0

SHI, Y.F., INVIVO ADMINISTRATION OF MONOCLONAL-ANTIBODIES TO THE CD3 T-CELL RECEPTOR COMPLEX INDUCES CELL-DEATH (APOPTOSIS) IN IMMATURE THYMOCYTES, JOURNAL OF IMMUNOLOGY 146: 3340 (1991).

SHI Y unpublished data.

SHI, Y.F., ACTIVATION-INDUCED CELL-DEATH IN T-CELL HYBRIDOMAS IS DUE TO APOPTOSIS - MORPHOLOGIC ASPECTS AND DNA FRAGMENTATION, JOURNAL OF IMMUNOLOGY 144: 3326 (1990).

SHI, Y.F., CYCLOSPORINE-A INHIBITS ACTIVATION-INDUCED CELL-DEATH IN T-CELL HYBRIDOMAS AND THYMOCYTES, NATURE 339: 625 (1989).

SMITH, C.A., ANTIBODIES TO CD3/T-CELL RECEPTOR COMPLEX INDUCE DEATH BY APOPTOSIS IN IMMATURE T-CELLS IN THYMIC CULTURES, NATURE 337: 181 (1989).

SWAT, W, DETECTION OF APOPTOSIS OF IMMATURE CD4+8+ THYMOCYTES BY FLOW-CYTOMETRY, JOURNAL OF IMMUNOLOGICAL METHODS 137: 79 (1991).

UCKER, D.S., ACTIVATION-DRIVEN T-CELL DEATH .1. REQUIREMENTS FOR DENOVO TRANSCRIPTION AND TRANSLATION AND ASSOCIATION WITH GENOME FRAGMENTATION, JOURNAL OF IMMUNOLOGY 143: 3461 (1989).

VENTURELLI, D, INHIBITION OF T-CELL PROLIFERATION BY A MYB ANTISENSE OLIGOMER IS ACCOMPANIED BY SELECTIVE DOWN-REGULATION OF DNA-POLYMERASE ALPHA-EXPRESSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 5963 (1990).

10.1146/annurev.iy.08.040190.002531

WATERS, C.M., C-MYC PROTEIN EXPRESSION IN UNTRANSFORMED FIBROBLASTS, ONCOGENE 6: 797 (1991).

WURM, F.M., INDUCIBLE OVERPRODUCTION OF THE MOUSE C-MYC PROTEIN IN MAMMALIAN-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 5414 (1986).

WYLLIE, A.H., RODENT FIBROBLAST TUMORS EXPRESSING HUMAN MYC AND RAS GENES - GROWTH, METASTASIS AND ENDOGENOUS ONCOGENE EXPRESSION, BRITISH JOURNAL OF CANCER 56: 251 (1987).

WYLLIE, A. H., JOURNAL OF PATHOLOGY 142: 67 (1984).

10.1038/284555a0

YUH, Y.S., GLUCOCORTICOID EFFECT ON ONCOGENE GROWTH GENE-EXPRESSION IN HUMAN T-LYMPHOBLASTIC LEUKEMIC-CELL LINE CCRF-CEM - SPECIFIC C-MYC MESSENGER-RNA SUPPRESSION BY DEXAMETHASONE, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 10904 (1989).

ZACHARCHUK, C.M., PROGRAMMED LYMPHOCYTE-T DEATH - CELL ACTIVATION-INDUCED AND STEROID-INDUCED PATHWAYS ARE MUTUALLY ANTAGONISTIC, JOURNAL OF IMMUNOLOGY 145: 4037 (1990).